A 53 year old man presents with increasing gastric pain and is found to have a 3 cm mass located in the anterior wall of his stomach. This mass is resected and histologic examination reveals a tumor composed of cells having elongated, spindle-shaped nuclei. The tumor does not connect to the overlying gastric epithelium and is instead found only in the wall of the stomach. The tumor cells stain positively with CD117, but negatively with both desmin and S-100. Special studies find that these tumor cells have abnormalities of the KIT gene. Which of the following is the most likely diagnosis?

a. Lymphoma of mucosa-associated lymphoid tissue (MALToma)
b. Ectopic islet cell adenoma (VIPoma)
c. Gastrointestinal stromal tumor (GIST)
d. Submucosal leiomyoma ("fibroid tumor")
e. Nonchromaffin paraganglioma (chemodectoma)

Answers

Answer 1

Answer:

The correct answer is c. Gastrointestinal stromal tumor (GIST)

Explanation:

Gastrointestinal stromal tumors (GIST) are rare neoplasms that originate from mesenchymal cells, generally express the KIT receptor (CD117) and present activated mutations of the tyrosine kinase or tyrosine kinase receptor proto-oncogene, cKIT (it is the gene that encodes KIT protein synthesis). GISTs can be located in any portion of the wall of the GI tract, but most are located in the submucosa or in the muscularis propria. Some are predominantly extramural; large ones can infiltrate neighboring organs

Answer 2

A gastrointestinal stromal tumor (GIST) is the most likely diagnosis (Option C).

Cancer is a multifactorial disease in which cancer cells divide and proliferate to produce a tumor.

Cancer is often associated with mutations in key genes which are required for the normal functioning of a given tissue (e.g. cell cycle genes).

A gastrointestinal stromal tumor (GIST) is a tumor in which cells of the stomach proliferate in an uncontrolled manner.

In conclusion, a gastrointestinal stromal tumor (GIST) is the most likely diagnosis (Option C).

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Related Questions

Which phase of the cell cycle is the least common process of mitosis and what could be the reason?

Answers

Answer:

In anaphase, the shortest stage of mitosis, the sister chromatids break apart, and the chromosomes begin moving to opposite ends of the cell. By the end of anaphase, the 2 halves of the cell have an equivalent collection of chromosomes. In telophase, 2 daughter nuclei form. The nuclear envelope beings to reappear.

I need to know which ones to check off

Answers

The instructions don’t really count toward your grade, if you really wish to learn from then you should just try your best and take notes on what you beed to know. If you’re just using Brainly to get past the class just guess on the instructions as they do not effect your grade very much at all if at all.

A microbiologist is conducting a research project on chemolithoautotrophs. This means that the investigator is examining certain aspects of a bacterium that is a purple nonsulfur bacteria which depends on light. uses light as its energy source and carbon for organic compounds. can oxidize inorganic molecules such as ammonia and sulfur for energy. can use the energy from sunlight to build organic molecules from carbon dioxide. obtains carbon from organic molecules.

Answers

Answer:

uses light as its energy source and carbon for organic compounds.

Explanation:

The purple non-sulfur bacteria which depends on light produces organic food  just like plants through the process of photosynthesis. The purple non-sulfur bacteria uses carbondioxide and water with sunlight produces oxygen and glucose which is an organic compound. So that's why purple non-sulfur bacteria is also known as phototrophic means organism that produces their own food through photosynthesis.

If you wanted to study large, migratory grazing animals like wildebeest, which biome would you chose to visit?

Answers

Answer: Savanna

Explanation:

The Savanna is a biome located in Africa and characterized by a lot of grass and dispersed trees. The climatic conditions are warm all year round and the summers are wet.

The presence of so much vegetation makes it an ideal biome for large herbivores like elephants, giraffes and wildebeests. As a result of so many herbivores being there, there are lots of carnivores as well such as lions and cheetahs.

QUESTION:

╭☞ If you wanted to study large, migratory grazing animals like wildebeest, which biome would you chose to visit?

ANSWER:

╭☞ Savanna or Savannah

Explanation:

╭☞ Because Savanna or savannah, is a migratory grazing animals like wildebeest and type of plant that grows under hot, seasonal climatic conditions and is characterized by an open tree trunk (i.e., scattered trees) above a continuous- continuous tall grass understory (the layer of vegetation between the canopy of the forest and the ground).

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Darwin presented a hypothesis about how evolution takes place. Now this hypothesis has become a theory. What caused the idea to become a theory? A. Darwin shared his ideas with others, and many scientists have performed experiments that support this idea. B. Darwin is well respected, and scientists honor his work by referring to his idea as a theory. C. Darwin performed an experiment that supported his hypothesis. D. Darwin convinced everyone around him that it was a good idea.​

Answers

Answer:

C. Darwin performed an experiment that supported his hypothesis.

Explanation:

Darwin believed that his experiment, which was comparing the finch's beaks from Galapagos Archipelago, in which there was variation between the size and shape of beaks, as the basis in which he believed evolution was correct. However, variation does not mean evolution, and evolution, in which it calls for a chain of events to create beneficial traits successively, is nigh impossible to occur in the real world. Again, that is not to say that there is no such thing as variation, in which there is, in which people or animal groups adapt to their natural habitat. However, to state that adaptation is proof that a species becomes another is to go out on a limb, and current failures of "new species" (in that it originates from today's day and age, rather then discovered) to emerge is proof of such.

In general, men show _____ than women do. a. less facial expression b. more facial expression c. less envy or anger d. more envy or anger

Answers

Answer:

more envy and anger

Explanation: they cant control themselves lol.

Based on the Punnett square above, what are the genotypic and phenotypic ratios of the offspring? A red plant and a pink plant. Red plant genotype: Pink plant genotype: Phenotypic ratio: Red = Pink = White = Genotypic ratio: RR = Rr = rr =

Answers

Answer:

GivEn:

⠀⠀⠀⠀⠀⠀⠀

The ratio of two sides of a parallelogram is 2 : 5.Perimeter of parallelogram = 70 cm

⠀⠀⠀⠀⠀⠀⠀

To find:

⠀⠀⠀⠀⠀⠀⠀

Sides of parallelogram?

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Solution:

⠀⠀⠀⠀⠀⠀⠀

☯ Let two adjacent sides of parallelogram be 2x and 5x.

⠀⠀⠀⠀⠀⠀⠀

Refrence of image is shown in diagram:

⠀⠀⠀⠀⠀⠀⠀

[tex]\setlength{\unitlength}{1 cm}\begin{picture}(0,0)\thicklines\qbezier(1,1)(1,1)(6,1)\put(0.4,0.5){\bf D}\qbezier(1,1)(1,1)(1.6,4)\put(6.2,0.5){\bf C}\qbezier(1.6,4)(1.6,4)(6.6,4)\put(1,4){\bf A}\qbezier(6,1)(6,1)(6.6,4)\put(6.9,3.8){\bf B}\put(0.7,2.5){\sf 2x}\put(3,0.5){\sf 5x}\end{picture}[/tex]

⠀⠀⠀⠀⠀⠀⠀

[tex]\underline{\bigstar\:\boldsymbol{According\:to\:the\:question\::}}\\ \\[/tex]

Perimeter of parallelogram = 70 cm

⠀⠀⠀⠀⠀⠀⠀

[tex]\dag\;{\underline{\frak{We\;know\;that,}}}\\ \\[/tex]

[tex]\star\:{\boxed{\sf{\purple{Perimeter_{\;(parallelogram)} = 2 \times (sum\:of\: adjacent\:sides)}}}}\\ \\[/tex]

[tex]:\implies\sf 2 \times (2x + 5x) = 70\\ \\[/tex]

[tex]:\implies\sf 2 \times 7x = 70\\ \\[/tex]

[tex]:\implies\sf 14x = 70\\ \\[/tex]

[tex]:\implies\sf x = \cancel{ \dfrac{70}{14}}\\ \\[/tex]

[tex]:\implies{\boxed{\sf{\pink{x = 5}}}}\;\bigstar\\ \\[/tex]

Therefore,

⠀⠀⠀⠀⠀⠀⠀

2x = 2 × 5 = 10 cm.

5x = 5 × 5 = 25 cm.

⠀⠀⠀⠀⠀⠀⠀

[tex]\therefore[/tex] Hence, Adjacent sides of parallelogram are 10 cm and 25 cm.

The image shows a typical practice carried out by members of a society.
Which type of society does the image most likely represent?
A. Pastoral
B. Agrarian
C. Postindustrial
D. Hunter-gatherer

Answers

I think b not to sure

Agrarian type of society does the image most likely represent. So, the correct option is B.

What is Society?

A group of people who live in one place and share customs, cultures, organizations, and interests is referred to as a society. The diversity of people from different religions, castes, genders, and ethnic groups has several effects on this civilization.

Agricultural activities generally include everything that has a close connection to farming and makes use of land for farming and crop production. This activity, which uses a variety of contemporary techniques, has a close relationship with all human agricultural operations and is in charge of the massive crop output.

The image below depicts the task of planting paddy, which is typically done by a young child. Thus, the image most likely depicts an agrarian community.

Thus, C is the best choice.

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Table sugar is an example of which molecule

Answers

Answer:

Disaccharide

Explanation:

It is a disaccharide, a molecule composed of two monosaccharides: glucose and fructose. Sucrose is produced naturally in plants, from which table sugar is refined. It has the molecular formula C12H22011.

Answer:

table sugar is example of glucose. It has the molecular formula C12H22O11.

What two hormones rise in response to general stress?

Answers

Answer:

Adrenaline and Cortisol

Explanation:

Adrenaline increases your heart rate, elevates your blood pressure and boosts energy supplies. Cortisol, the primary stress hormone, increases sugars (glucose) in the bloodstream, enhances your brain's use of glucose and increases the availability of substances that repair tissues.

state 2 function of the kidney

Answers

ʕ•ﻌ•ʔ[tex]\huge\bold\pink{hello!!!}[/tex]ʕ•ﻌ•ʔ

HERE IS UR ANSWER

_____________________

The kidneys are powerful chemical factories that perform the following functions:

remove waste products from the body.remove drugs from the body.balance the body's fluids.release hormones that regulate blood pressure.produce an active form of vitamin D that promotes strong, healthy bones.
It removes waste products from the body. And also removes drugs from the body

People's movements between places is called _____________________.

Answers

Answer:

spacial interaction I think. I hope this helps!

Answer:

people's movements between places is called human migration .

What is limiting factor

Answers

Answer:

limiting factors are often referred as a lack of a particular resource .

Describes vitamin D levels and problems

Answers

Answer:

Vitamin D is essential for strong bones,because it helps the body use calcium from the diet.

It’s important for normal growth and development of teeth and bones. It can help resist against certain diseases. Some problems if you take to much vitamin D is that you will get weakness, fatigue, sleepiness, headache, loss of appetite, dry mouth, metallic taste, nausea, vomiting, and others.

Every day we make choices that can potentially affect our environment. For example, we may toss a plastic drink bottle into the nearby trash because it’s more convenient than walking all the way to the recycling bin. Think about three choices you made this week that could have affected the environment. Did your choices have a positive or a negative effect on the environment? Explain your reasoning.

Answers

First, I chose to put a Chipotle container into the trash, instead of the recycling. This wasn’t the best decision, because it could have gone to the recycling and helped others.

Secondly, my family owns a compost bin and compost machine that helps compost vegetable waste, fruit scraps, coffee grounds, and other compostable items. Choosing to do this helps the environment in many ways.

Thirdly, I picked up many aluminum cans on the side of the road to crush and collect. After several months of collecting them in a container, my family and I bring them to a place that recycles and reuses metals and aluminum.

The three choices that could have affected the environment are as follows:

Utilization of plastic to make it easy for carrying objects.Plants trees in order to build a green environment. Overdependency on vehicles rather bicycles and pedestrians.

What is Environment?

The environment may be defined as anything which is present in the surroundings of living organisms. This environment basically has two types of factors biotic and abiotic factors.

In the above three choices, building a green environment has a positive effect on the environment. It may also affect living organisms positively. While the rest of the two may stimulate a negative impact on the environment by increasing the levels of carbon dioxide by liberating emission and non-biodegradable plastics.

Therefore, the three choices that could have affected the environment are well mentioned above.

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Describe the relationship between the surface area and the volume of a cell. Analyze the data and explain why cells are often flattened instead of cube-shaped.

Answers

Answer:

Inverse relation.

Explanation:

There is an inverse relationship between the surface area and the volume of a cell because one increases the other decreases. When a cell grows bigger in size, its internal volume enlarges and the cell membrane start expanding. Unfortunately, the volume increases more rapidly than the surface area of the cell. So the surface area available to pass materials to a unit volume of the cell steadily decreases. Cells are often flattened instead of cube-shaped because the surface area increases. Due to surface area increases, more materials to be absorbed through the cell membrane at a greater rate than that of a cell with smaller surface area.

PNS axons are vulnerable to cuts, crushing injuries, and other types of trauma. However, a damaged ____________ can regenerate if the ____________ remains intact and a critical amount of ____________ remains. The success of peripheral nervous system axon regeneration depends upon two primary factors: (1) the amount of ____________ and (2) the ____________ between the site of the damaged axon and the ____________ . The possibility of repair is ____________ with an increase in either of these two factors. Neurolemmocytes play an active role in regeneration

Answers

Answer:

The correct answer is - damaged, effector organ, neurilemma, damage, distance, cell body, decreased.

Explanation:

PNS axons are prone to cuts, and other types of injuries. A damaged axon can regenerate if the effector organ remains intact and a critical amount of neurilemma is found.

The degree of success of these axons regeneration depends upon factors that are (1) the amount of damage, and (2) the distance between the site of the damaged axon and the cell body it innervates The possibility of repair is reduced with an increase in either of these two factors. Neurolemmocytes play an active role in regeneration

In which of the scientific classifications are all the
animals grouped

Answers

The lion belongs to the following groups: Kingdom Animalia (includes all animals) Phylum Chordata (includes all vertebrate animals, as well as some other more primitive ones) Class Mammalia (includes all mammals)

Describe the unknown in terms of what you are able to determine from the tests. Is it primary, secondary, or tertiary

Answers

Answer:

This question in incomplete, therefore it will be trickier to answer.

Explanation:

If you provide the options with this question, I can give it a shot in trying to work it out.

A certain animal species has either curly tails (C) or straight tails (c) and either hazel eyes (H) or blue eyes ( h). What are the possible genotypes of an animal with curly tails and blue eyes

Answers

Answer:

CChh

Cchh

Explanation:

Cc or CC can be a genotype for curly tails because both have a dominant allele for curly tails

hh can be a genotype for blue eyes because there are two recessive alleles for blue eyes that are present

Suppose beak size currently ranges from 6-10mm. If directional selection favors larger beaks (up to a max of 15mm), which statement is true?

Answers

source of variation needs to create that size

Explain the role of cellular respiration in a cell.

Answers

Answer:

Every cell performs a type of cellular respiration as it is required to produce energy. The point of cellular respiration is to turn high-energy molecules, know as glucose, into ATP, a form of usable energy. There are two types of respiration, aerobic and anaerobic. Aerobic goes through 3 stages and produces the most ATP by using oxygen and releasing carbon dioxide. Anaerobic does the same job but only uses one stage and produces much less ATP. This process gives the cell energy and continues the carbon cycle.

which photo synthetic process can occur at night?
A.the reaction at photosystem 1
B.the formation of NADH
C.the calvin cycle
D.the reaction at photosystem 2

Answers

Its most likely D because it’s more reasonable

Look at the diagram below.
Х

Which best describes the structure labeled X in the diagram?

Answers

Answer:

C

Explanation:

Its transfer element through it channel

What is pasteurization? what is the advantage of this technique?

GIVE ANSWER IN POINTS
CLASS 8 ​

Answers

Answer:

Pasteurization is the process by which food products (such as juice and dairy products) are mildly heated to kill off harmful bacteria, salmonella, and other disease-causing pathogens. These products are thus made safe for consumption. ... Pasteurization has revolutionized food safety within the dairy industry.

The most direct method by which an ion or molecule can move across a cell membrane is by ____________.A. using an integral protein.B. a sodium-potassium pump.C. simple diffusion. D. active transport.E. osmosis.

Answers

Answer:

C. Simple diffusion

Explanation:

Simple diffusion from a high to low concentration is the most direct method that ions or molecules can move across a cell membrane.

Through this method, no proteins are required for transport, and no energy is used.

The ion or molecule being transported directly moves across the cell membrane, without any other factors involved.

So, the correct answer is C. Simple diffusion

If the stomata remain closed due to water loss, what happens to the concentration of CO2 and O2 in the leaf

Answers

Answer:

Fixation of oxygen occur instead of carbondioxide.

Explanation:

If the stomata remain closed due to water loss, the concentration of carbondioxide decreases and oxygen increases in the leaf because of the fixation of oxygen instead of carbondioxide by rubisco. The plant takes carbondioxide from the atmosphere when the stomata is open so when the stomata is closed there is no other way for getting carbondioxide into the leave so the oxygen is now being fixed by our rubisco enzyme to that five-carbon compound instead of carbon dioxide.

Mode of action of aldehydes and Quaternary ammonium compounds is

Answers

Answer:

Aldehydes have antibacterial, antifungal, antiviral and sporicidal activity. These are helpful to destroy the spores of Bacillus subtilis and Clostridium sporogenes. Glutaraldehyde and formaldehyde are commonly used aldehydes in disinfectants.

Quaternary ammonium compounds work by denaturing the proteins of the bacterial or fungal cell, affecting the metabolic reactions of the cell and causing vital substances to leak out of the cell, causing death.

Which of these organelles prepares proteins to be fully functional?

A. Rough endoplasmic reticulum

B. Large vacuoles

C. Smooth endoplasmic reticulum

D. Chloroplasts

Answers

Rough endoplasmic reticulum

Answer:

Rough endoplasmic reticulum is among the organelles that are found in eukaryotic cells. The reason as to why it is called rough is because it has ribosomes attached to its surface. Its main function is to produce proteins.

Explanation:

a que distancia se encuentra una gaviota respecto del nivel del mar?​

Answers

Answer:

Para determinar la distancia a la que se encuentra una gaviota respecto del nivel del mar, es necesario medir la altura a la que se encuentra volando. Así, dado que el nivel del mar tiene una altura considerada como de 0 metros, si la gaviota está volando a unos 500 metros de altura, por ejemplo, esa será su distancia respecto del nivel del mar.

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