As part of your research, you examine mRNA expression for the parents, their two unaffected children, and their affected child with a Northern blot using a full-length cDNA probe.Your results, shown here, are as follows:Both parents have low, but detectable, mRNA expression.The unaffected children have either normal or low mRNA expression.The affected child has no detectable mRNA expression. What possible molecular defect could explain these results?Select every legitimate possibility from the choices below.a. The recessive allele could be a premature stop codon that prevents the translation of a full-length protein.b. The recessive allele could be a mutation in the promoter region that prevents RNA polymerase II from binding.c. The recessive allele could be a mutation in the transcribed region that makes the mRNA unstable and causes it to degrade.d. The recessive allele could be a mutation in regulatory DNA that prevents chromatin from being remodeled from a closed to an open state.e. The recessive allele could be a mutation in a splice donor or acceptor sequence that prevents proper mRNA splicing, leaving an intron in the spliced transcript.

Answers

Answer 1

Answer:

b.c d are the answer options

Explanation:

b. The recessive allele could be a mutation in the promoter region that prevents RNA polymerase II from binding.

c. The recessive allele could be a mutation in the transcribed region that makes the mRNA unstable and causes it to degrade.

d. The recessive allele could be a mutation in regulatory DNA that prevents chromatin from being remodeled from a closed to an open state.

in option b, the synthesis of mRNA is going to be halted

in option c, mRNA is undergoing degradation, it will be invisible in the northern blot.

in option d, mRNA in expression of each gene is going to be turned off.

.


Related Questions

What alternate form of genes do nucleic acids have that allows them to offer variability?

Answers

Answer:

allales

Explanation:

an allele is the variant from a gene

Answer:

A. allales

Explanation:

PLS ANYONE IT'S URGENT Explain eubacteria ?

Answers

Eubacteria, or “true” bacteria, are single-celled prokaryotic microorganisms that have a range of characteristics and are found in various conditions throughout all parts of the world.

Answer:

Eubacteria are PROKARYOTIC organisms characterized by the lack of membrane and have peptidoglycan on cell wall when present.

Explanation:

They include most of the familiar bacteria such as E.

Hope it helps.

Which of the circumstances below most accurately describes conditions that are likely to permit a robust anti-tumor adaptive immune response?

a. A tumor with high expression of proteins that have mutations in sequences encoding HLA-binding peptides.
b. A robust acute inflammatory response to PAMPs expressed specifically by tumor cells.
c. Anti-tumor T lymphocytes that have high expression of CTLA-4.
d. A tumor with high expression of PD-L1.

Answers

Did you ever figure out the answer to this question?

The study of PAMP-DAMP complexes is vital to the advancement of knowledge regarding inflammatory disorders in general and cancer in particular. Therefore, option (B) is correct.

What is PAMP-DAMP complexes?

Increasing evidence links inflammation to cancer, and at the root of inflammation are PAMPs and DAMPs (DAMPs). Microorganisms contain PAMPs, which are detected by pattern recognition receptors on monocytes and DCs (PRRs). PRR activation produces pro-inflammatory cytokines.

A robust immune response requires endogenous chemicals that pose 'risk' to self-tissues and are created by injured or stressed cells; these are DAMPs, which also trigger inflammation. PAMPs and DAMPs each have about 100 receptors. PAMPs and DAMPs interact; a PRR can bind to both. In this system, PAMPs and DAMPs affect each other's activation threshold. Thus, PAMP-DAMP relationships describe inflammation in a predictable 'inflammatory code'

PAMP-DAMP complexes are key to understanding inflammatory disorders and cancer.

Learn more about adaptive immune response, here:

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Which of the following is an example of a non-mendelian pattern of inheritance? A) all traits are inherited through patterns found by Mendel. B) when individuals with the genotype BB cross, all the offspring have brown fur. C) when pea plants that are hetero-zygous for a certain trait cross some of the offspring express both distinct versions of the trait. D) when horses that are homo-zygous for red hair are crossed with horses that are homo-zygous for white hair, the offspring have both red and white hair.

Answers

The correct answer is B

write a poem about culture
give expiation for your answer
and describe how to write poem
and don't forget to write poem about culture?
please please answer this question ​

Answers

Explanation:my culture is pakistan and it's tradition and colours are well , most people decorate the buses on 14th august people do face painting and make delicious food in world there are many types of cultures and tradition, which people celebrate once in a year

I HOPE WHOEVER YOU ARE LOVE THE POEM AND PLEASE LIKE YOUR CULTURE IN WHATEVER COUNTRY YOU ARE BORN BECUASE IT'S YOUR COUNTRY WHICH IS BEAUTIFUL LIKE MY COUNTRY.

The ostrich is a bird. However, it has traits that are different from those of the birds we typically see flying around our neighborhoods. Using credible sources, investigate the environment and adaptations of ostriches to explain how they evolved to survive in their environment.

Answers

Answer:

According to National Geographic, ostriches are a part of a very small group of birds that cannot fly because unlike most birds, their small wings are not strong enough to carry their body for flight and their breastbone isn't balanced enough for flying. Birds that are unable to fly are called ratites.

A number of scientists namely Thomas Huxley, Richard Owen, and others have tried to show that these ratites are actually related to each other and eventually, it was discovered that they all had one thing in common, the way the bones at the roof of the mouth were arranged was similar to that of reptiles rather than other birds.

Richard Owen found and assembled the remains of an extinct ostrich skeleton which was an extinct moa and contrary to already held opinion, one ratite known as tinamous did not really fit with the profile of a ratite because it could fly, even though almost grudgingly and they possessed keeled sternum which suggests that they evolved from flying birds.

DNA tests showed that tinamous evolved within ratites and not necessarily as a separate entity. The tests also showed that moas and tinamous are related.

It was also speculated that the division of the supercontinent Pangaea southern side led to the separation of flightless ratite ancestors, causing each landlocked group to evolve and become the flightless birds we know today such as the ostrich, rheas, etc.

Answer:

An ostrich is an extremely large bird that lives in Africa. It can’t fly, but it has powerful legs that allow it to outrun most predators. Its flexible knees and two-toed feet enable it to run easily. An ostrich has strong leg muscles that it can use to kick large predators. It has claws on its wings to defend itself from predators and thick feathers to keep it warm at night. Ostriches have thick eyelids that protect their eyes from sandstorms.

Explanation:


Evidence without_______
increases its reliability.
a
bias
b
question
с
repetition
d
replication

Answers

Answer:

I'll say its B ) Question

Explanation:

because when your proving something with evidence then you start asking questions (or still have questions) makes it seem like you don't really know.

blood consists of which fluid medium
a.lymph
b.platelets
c.plasma
d.all of these

Answers

Answer:

C. Plasma

Explanation:

Blood consists of a fluid medium called Plasma.

Taxonomists today tend to group organisms into the same category based on similar what?

Answers

Answer:

characteristics

Explanation:

oranisms are grouped based on shared characteristics

Taxonomists today tend to group organisms into the same category based on their evolutionary history and shared ancestry, as explained in Option A, as this allows taxonomists to construct more accurate and detailed phylogenetic trees.

What is taxonomy?

The field of taxonomy is concerned with the classification of living organisms based on their shared characteristics, the aim of taxonomy is to group organisms in a way that reflects their evolutionary history and to provide a standardized system of naming, while earlier taxonomists relied on morphological characteristics, such as the physical appearance of an organism, but modern taxonomists instead use molecular and genetic data to group organisms into categories.

Hence, taxonomists today tend to group organisms into the same category based on their evolutionary histories and shared ancestry, as explained in Option A.

Learn more about the taxonomy here.

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The question is incomplete, complete question is below

Taxonomists today tend to group organisms into the same category based on similar what?

A)based on their evolutionary histories and shared ancestry

B)based on fossils

Which of the following best explains the potential health problems associated with endocrine disruptors? A) Endocrine disruptors are the only available pesticides,hence they are used widely. B) Endocrine disruptors mimic hormones that regulate critical biological processes. C) Endocrine disruptors do not biodegrade, remaining toxic years after their release. D) There are no major health problems associated with exposure to endocrine disruptors. E) Endocrine disruptors encompass a wide array of toxic pesticides.

Answers

B) Endocrine disruptors mimic hormones that regulate critical biological processes.

Endocrine disruptors, at times moreover called as hormonally unique trained professionals, endocrine disturbing engineered substances, or endocrine upsetting blends are manufactured substances that can interfere with endocrine structures. These aggravations can cause threatening developments, birth flees, and other developmental issues.

The potential health problems associated with endocrine disruptors is that Endocrine disruptors mimic hormones that regulate critical biological processes.

For more information:

https://brainly.com/question/22965068?referrer=searchResults

Answer:

It's A.) Endocrine disruptors mimic hormones that regulate critical biological processes.

Explanation:

Quizlet gave me the answer

Why do you think premenopausal women need more iron than
men of the same age?

Answers

Answer:

Women need more iron than men to make up for the amount of iron they lose in their menstrual period.

Explanation:

Answer:

Premenopausal women shed blood as part of menstruation every month, which lowers the level of iron in the body. So, they need more iron than men and are also at a greater risk for this nutritional deficiency.

PLATO

Explanation:

Aquatic organisms in coastal areas face a variety of predators on land and in the water and air. Which ocean process exposes the coastal aquatic organisms to land-based predators? a. Changing wind patterns alter the ocean currents, changing tide levels. b. Daily tidal patterns leave areas exposed to the land for part of the day. c. The constant wave action generates nutrients that attract predators. d. The ocean conveyor belt raises and lowers the water levels on the coasts.

Answers

Answer:

b

Explanation:

The correct answer as to the ocean process that exposes the coastal organisms to land-based predators would be the daily tidal patterns that leave the coastal area exposed to the land for a part of the day.

Some parts of the coastal areas become exposed to land during certain periods of the day as a result of tidal waves. When this happens, the aquatic organisms occupying these coastal areas become temporarily exposed to land predators who hunt and kill them for food.

Therefore, the correct option is b.

all of the following are examples of organic matter soil except

Answers

This question is incomplete; here is the complete question:

All of the following are examples of organic matter soil except

A. Decaying plants

B. Bacteria

C. Fungi

D. Water

The answer to this question is D. Water

Explanation:

Organic matter derives from living beings, due to this, organic matter is considered as a biological product. In this context, materials such as decaying plants are organic matter because they derive from living organisms and contain biological molecules (most contain carbon). This category does not apply to water, which is composed of hydrogen and oxygen and does not derive from living beings. Thus, the one that is not organic matter is water.

Answer:

D. Water

Hope this Helps!! :))

Choose only one correct option. Explanation needed.

Answers

Answer: D

only green plants

Answer:

[tex]\large \boxed{\mathrm{D. \ Photosynthesis}}[/tex]

Explanation:

Photosynthesis is a characteristic present in plants. Photosynthesis is a process where plants transform light energy into chemical energy. Reproduction, respiration, and excretion are all characteristics of living organisms.

I need help with this

Answers

Answer:

I know the answer

Explanation:

Yes

Yes

Yes

Drag each tile to the correct box. Place the items in order from lowest to highest degree of internal organization. Please answer 1st at the top and last at the botttom

Answers

Answer:

Lowest to highest degree of internal organization form the given items are:

1) Digestive system: Digestive system is a type of organ system, which is consist of several digestive organs such as mouth, stomach, pancrease and intestine.

2) Stomach: Stomach is a type of organn which is a functional group of tissues.

3) Stomach lining tissues: These are functional group of cells.

4) Epithelial stomach cell: cell is a basic unit of all life.

Hence, the correct order form loowest to highest degree of internal organization is:

Digestive system => Stomach => Stomach lining tissues => Epithelial stomach cell

Which is a feature of a tonic receptor? Select one: a. The action potential occurs when there is a change in response to a change in condition. b. For this receptor, the stimulus begins with a burst of action potentials. c. They are normally inactive. d. When the stimulus changes the action potential generation changes. e. Provides information about the rate and change of the stimulus. f. The action potential is generated for a short time period.

Answers

Answer:

For this receptor, the stimulus begins with an explosion of action potentials.

that would be the correct option.

Explanation:

A tonic receptor is one that is activated when the action potentials were maintained over time and during the signaling of the receptor.

Tone receptors require continuous stimulation over a period of time to trigger a response and deliver it to the central nervous system.

It keeps the nervous system constantly active in the environment that surrounds it.

They are slowly adaptable, an example of these receptors are the merkel and ruffini receptors.

Describe your plan to preserve the biodiversity of the town's lake. Make sure to include the materials that you would need for your plan to work and how you would scale it up to test it.

Answers

Answer:

10 Ways to Protect and Conserve Biodiversity

Government legislation.

Nature preserves.

Reducing invasive species.

Habitat restoration.

Captive breeding and seed banks.

Research.

Reduce climate change.

Purchase sustainable products.


is the basic unit of structure and function of living things.

Answers

Answer:

cells

Explanation:

is the basic unit of life :)

Match each part of Sammi's model to the bodily structure it represents. One bodily structure has already been labeled for you.

Answers

Answer:

corrugated cardboard tube - digestive tract

irregular surfaces on the corrugated tube - villi

pump - heart

Plastic tubing - blood vessels

Explanation:

The corrugated cardboard tube represents the digestive tract.  The give away was the presence of the irregular surfaces within the tubes. This is called the villi. The villi is responsible for the absorption of food after digestion into the body.

Irregular surfaces on the corrugated tube represent the villi. They are tiny hair-like structures that are in the small intestine, that are responsible for the absorption of food into the bloodstream.

The pump represents the heart. The heart is the only organ in the body that provides the pressure force that pushes the blood throughout the body. In this model, the pump will most likely be performing the same function.

The plastic tubings are meant to contain one form of fluid or the other. Judging from that, they can be said to represent the blood vessels. This is because they are connected to the heart and are meant to transport bodily fluids around the body

Answer:

corrugated cardboard tube - digestive tractirregular surfaces on the corrugated tube - villipump - heartPlastic tubing - blood vessels

Explanation:

Shell coiling in some snails has been found to be determined by the genotype of the snail's mother, rather than its own genotype. This is termed:

Answers

Answer:

maternal effects

Explanation:

The correct answer would be maternal effects.

The maternal effect is a genetic phenomenon that is characterized by an organism having the phenotypic expression that is compatible with the genotype of its mother irrespective of the organism's genotype itself.

This condition often occurs as a result of the mother supplying messenger RNA or protein to the egg that results in the formation of a zygote/embryo. Consequently, the genome of the mother dictates the functionality of the molecule in such offspring.

Properties of Water Lab Report

Instructions: Choose a property of water and design an experiment to test the property. Use the following lab template to ensure all lab report components are included.

Title:

Objective(s):
Identify the purpose of your investigation or the question you are attempting to answer. Be sure to tie in the property of water you are testing.

Safety Notes:
Always have parent(s) or guardian(s) permission and supervision when performing a lab activity at home.
Wear proper protective clothing and eyewear when needed.
Be sure to dispose of all materials properly.
Always wash your hands carefully after touching anything in a lab investigation.
Hypothesis:

Variables:
Independent Variable:
Dependent Variable:
Controlled Variable:

Materials:

Procedure:
The procedure should be clear and detailed so that others can repeat it. The details should be specific in how the procedure changes the independent variable, controls all variables that need to be controlled, and observes or measures the resulting changes to the dependent variable.

Data and Observations:
Present all data and observations in a neat and organized manner. Include tables and graphs where appropriate/possible.



Conclusion:
Be sure to answer the following reflection questions as a summary in the conclusion of your lab report:
Was your hypothesis correct? Why or why not?
What were the results of your experiment?
What changes would you make if you were to repeat the experiment?

Questions:
Using what you have learned in the lesson and the experiment, answer the following question in complete sentences.
Analyze the property of water you investigated and provide some real-world applications of the importance of this property of water.

Answers

Answer:

Hypothesis: I think the penny will hold more droplets plain water because adding soap to the water will disrupt surface tension

Independent variable: Penny and water dropper

Dependent variable: plain water

Independent variable:soapy water

Hope this helped

Which conclusion can be drawn from the experimental observation that a single strand of DNA contains 2100 dA residues and 1800 dT residues?

Answers

a. There must have been some loss of material in the extraction because the number of dA and dT residues must be the same.

b. This is a palindromic sequence.

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

d. This must be prokaryotic DNA

e. None of these

Answer:

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

2. Name the sympathetic ganglia in which the preganglionic and postganglionic neurons synapse.

Answers

Answer:

The paravertebral ganglia is the sympathetic ganglia where the pre-ganglionic and post-ganglionic neurons synapse.

Explanation:

Which of the following is an example of reproductive isolation?

Answers

Answer:

the example of reproductive isolation is temporal isolation, ecological isolation, behavioral isolation, mechanical isolation.

When a bacterium such as E. coli is shifted from a warmer growth temperature to a cooler growth temperature, it compensates by

Answers

Question is incomplete, The complete question is as follows:

When a bacterium such as E. coli is shifted from a warmer growth temperature to a cooler growth temperature, it compensates by:

A) increasing its metabolic rate to generate more heat.

B) putting longer-chain fatty acids into its membranes.

C) putting more unsaturated fatty acids into its membranes.

D) shifting from aerobic to anaerobic metabolism.

E) synthesizing thicker membranes to insulate the cell.

Answer:

C) putting more unsaturated fatty acids into its membranes.

Explanation:

Bacteria has the ability to change the composition of fatty acid present in its cell membrane to compensate the change in temperature.

When bacterium E.Coli will shift from hight or warmer temperature to low or cooler temperature, it will put more unsaturated fatty acids into its membranes which will mintain the fluidity in the membrane.

Hence, the correct option is "C".

What are two major drivers of surface ocean current and deep ocean current? 1. Surface ocean current 2. Deep ocean current The choices are: A. Differences in water density, resulting from the variability of water temperature and salinity B. Global wind systems

Answers

Answer:

1-B 2-A

Explanation:

this is because the wind blowing over the water causes motion whereas deep water is effected by Differences in water density, resulting from the variability of water temperature and salinity

A paleontologist finds a relatively complete skeleton but isn’t sure if it is an ape fossil or a hominid fossil. Which of the following features would NOT help distinguish between the two choices?
a. position of the opening in the skull for the spinal cord
b. design of the pelvis
c. relative length of the hind limbs
d. position of the eyes

Answers

c. relative length of the hind limbs. Overall fossilized apes and hominids are 90+% similar in the past 3.5 million years since Australopithecus afarensis but this one aspect of upper vs. lower limbs is the greatest difference. Hope this helps!

ASAP What is a photosynthetic pigment? What is a photosynthetic pigment? A. An oxygen based compound that captures light energy. B. A light sensitive compound that changes color. C. A colored compound that captures light energy. D. A manmade compound that reacts to light.

Answers

I think the answer is A.

Answer:

A. An oxygen based compound that captures light energy.


Identify the organelle where photosynthesis takes place.

B

C

D

E

Answers

Answer:

E

Explanation:

If E is the Chloroplasts, where photosynthesis takes place, then the answer is E.

Answer:

E

Explanation:

Other Questions
which expression is equivalent to(xy)? My loving people, We have been persuaded by some that are careful of our safety, to take heed how we commit ourselves to armed multitudes, for fear of treachery; but I assure you I do not desire to live to distrust my faithful and loving people. Let tyrants fear, I have always so behaved myself that, under God, I have placed my chiefest strength and safeguard in the loyal hearts and good-will of my subjects; and therefore I am come amongst you, as you see, at this time, not for my recreation and disport, but being resolved, in the midst and heat of the battle, to live and die amongst you all; [1] to lay down for my God, and for my kingdom, and my people, my honour and my blood, even in the dust. [2] I know I have the body but of a weak and feeble woman; but I have the heart and stomach of a king, and of a king of England too, and think foul scorn that Parma or Spain, or any prince of Europe, should dare to invade the borders of my realm; to which rather than any dishonour shall grow by me, [3] I myself will take up arms, I myself will be your general, judge, and rewarder of every one of your virtues in the field. I know already, for your forwardness you have deserved rewards and crowns; and We do assure you in the word of a prince, they shall be duly paid you. In the mean time, my lieutenant general shall be in my stead, than whom never prince commanded a more noble or worthy subject; not doubting but by your obedience to my general, by your concord in the camp, and your valour in the field, we shall shortly have a famous victory over those enemies [4] of my God, of my kingdom, and of my people.Selection 3 from the speech is an example of which of the following of rhetorical devices? which statement is true about which branch of the United States government enforces the law Two years ago, a customer purchased 1,000 shares of ABC stock at $45 per share. The stock has appreciated in value and is currently worth $60,000. The company announces that it is spinning off a subsidiary, DEF, to its shareholders. The value of the new company being spun off equals 5% of the old company. The customer will have:___________ Shalom, Guys! The molar mass of strontium (\ce{Sr}SrS, r) is \pu{87.62 g/mol}87.62 g/mol87, point, 62, space, g, slash, m, o, l. Calculate the number of atoms in a \pu{67.5 mg}67.5 mg67, point, 5, space, m, g sample of \ce{Sr}SrS, r. Write your answer in scientific notation using three significant figures. \text{atoms Sr} ______________ atoms Sr Love, Piper Rockelle Why must corporate managers use multiple techniques of project evaluation? Which technique is most commonly used and why? Describe several ways you may be able to use the techniques above as you progress in your professional career. Explain why chlorine is a gas while iodine is a solid yet both are halogens. Select one: a. Both iodine and chlorine differ in strength of metallic bonds b. Chlorine has strong inter molecular forces than iodine c. Iodine molecules are large with strong inter molecular forces than chlorine An electron and a proton are 6.5x10 ^ -11 m apart, find the magnitude of the electric and gravitational force between the two particles HELP PLEASE PLEASE :( Divide 50 by 25 and find the remainder to complete the equation:50 = 25 x ? + ? If the cost of fencing a rectangular garden per meter is rupees 5 . Find the amount needed to do the fencing of the garden with length 400 m and breadth 150 m . evaluate 15.2% of a 726 + 12.8% of 673 McConnel corporation has bonds on the market with 16.5 years to maturity, a YTM of 7.7 percent, a par value of 1000 and current price of 1065. The bonds make semiannual payment and have a par value of $1,000.Required:What must the coupon rate be on these bonds? Emission of which one of the following leaves both atomic number and mass number unchanged? (a) positron (b) neutron (c) alpha particle (d) gamma radiation (e) beta particle Kelvin wants to know whether he skied without falling more than twice as long as anyone else in his family. His dad tells him that he can check by using the inequality 2f < 223, where f is the time skied in seconds for each person. Plug the values for the time skied by each person into the inequality to find the answer.Lori55 Vanessa265 Devon172 Celia112 Arnold356 find the domain of the graphed function. I NEED THE ANSWER ASAPThe number of students who smoke cigarettes at Broxton College is decreasing at a rate of one smoker every 6.31 days. At what rate in smokers per year is the number of smokers declining? Assume 365 days in a year and round to the nearest tenth of a smoker per year innovation of the construction of the hoover dam Please help! Lorraine and Jake can produce any combination of peaches and nectarines described by the production possibilities curve above using the same amount of resources. Who has the absolute advantage in the production of each product? Explain. Who has the comparative advantage in the production of each product? Explain. Who will specialize in the production of each product? Explain using the concept of opportunity cost. A manufacturing company has variable overhead costs of $2.50 per unit and fixed costs of $5,000 per month. Each unit requires 4 hours of direct labor and the company expects to produce 2,000 units each month. The standard overhead rate will be