Determine the effect each given mutation would have on the rate of glycolysis in muscle cells.

a. loss of binding site for fructose 1 ,6-bisphophate in pyruvate kinase.
b. loss of allosteric binding site for ATP in pyruvate kinase.
c. loss of allosteric binding site for AMP in phosphofructokinase.
d. loss of regulatory binding site for ATP in phosphofructokinase.

1. Increase
2. decrease
3. No effect

Answers

Answer 1

Answer:

a. Decrease

b. Increase

c. Increase

d. No effect

Explanation:

Glycolysis is present in muscle cells which converts glucose to pyruvate, water and NADH. It produces two molecules of ATP. Cellular respiration produces more molecules of ATP from pyruvate in mitochondria. Glycolysis increases in pyruvate kinase.

Answer 2

a. Loss of binding site for fructose 1,6-bisphosphate in pyruvate kinase: Decrease

b. Loss of allosteric binding site for ATP in pyruvate kinase: No effect

c. Loss of allosteric binding site for AMP in phosphofructokinase: Increase

d. Loss of regulatory binding site for ATP in phosphofructokinase: Increase

A. An important substrate in the glycolysis pathway is fructose 1,6-bisphosphate. It stimulates pyruvate kinase, an essential enzyme in glycolysis. The amount of pyruvate kinase that is activated will decrease if the fructose 1,6-bisphosphate binding site in pyruvate kinase is eliminated. As a result the rate of glycolysis in the muscle cells will probably decrease.

B. The allosteric ATP binding site of pyruvate kinase controls how active the enzyme is. However, pyruvate kinase is not significantly regulated by ATP in muscle cells. Therefore, it is unlikely that deletion of the ATP-binding allosteric site in pyruvate kinase would have no effect on the rate of glycolysis in muscle cells.

C. The rate-limiting enzyme in glycolysis, phosphofructokinase, is activated from all forms by AMP. It increases the rate of glycolysis by stimulating the activity of phosphofructokinase. If the allosteric binding site for AMP is eliminated, phosphofructokinase activation will be reduced. As a result, the rate of glycolysis in muscle cells will decrease.

D. Phosphofructokinase is inhibited allosterically by ATP. It regulates the rate of glycolysis by a feedback mechanism. High ATP concentrations cause phosphofructokinase to bind to its regulatory site, limiting its activity and delaying glycolysis. If the regulatory binding site for ATP is eliminated, the inhibitory action of ATP on phosphofructokinase would be lost. As a result, muscle cells will glycolysis at a faster rate.

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Related Questions

A chemical reaction in a bomb calorimeter evolves 3.86 kJ of energy in the form of heat. If the temperature of the bomb calorimeter increases by 4.17 K, what is the heat capacity of the calorimeter?

Answers

Answer:

925.66 J/K

Explanation:

Applying,

Q = CΔt............. Equation 1

Where Q = amount of heat, C = heat capacity of the calorimeter, Δt = rise in temperature.

make C the subject of the equation

C = Q/Δt.............. Equation 2

From the question,

Given: Q = 3.86 kJ = 3860 J, Δt = 4.17K

Substitute into equation 2

C = 3860/4.17

C = 925.66 J/K

Consider the reaction: NaNO3(s) + H2SO4(l) NaHSO4(s) + HNO3(g) ΔH° = 21.2 kJ

How much heat must absorbed by the reaction system to convert 100g of NaNO3 into NaHSO4(s)?

Answers

Answer:

endet nach selam nw

4gh7

Tick (√) the statements that are correct.

a) By eating rice alone, we can fulfil nutritional requirement of our body. ( )
b) Deficiency Diseases can be prevented by eating a balanced diet. ( )
c) Balanced diet for the body should contain a variety of food items. ( )
d) Meat alone. is sufficient to provide all nutrients to the body. ( )​

Answers

b) (√)

c)(✓)

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What is the molecular geometry of CIO3F as predicted by the VSEPR model?

Multiple Choice
trigonal pyramidal
square planar
square pyramidal
tetrahedral
octahedral

Answers

Explanation:

since there are no lone pairs on the central atom, the shape will be tetrahedral

A uniform plastic block floats in water with 50.0 % of its volume above the surface of the water. The block is placed in a second liquid and floats with 23.0 % of its volume above the surface of the liquid.
What is the density of the second liquid?
Express your answer with the appropriate units.

Answers

Answer:

density of second liquid = 650 kg/m³

Explanation:

Given that:

The volume of the plastic block submerged inside the water  = 0.5 V

The force on the plastic block  = [tex]\rho_1V_1g[/tex]

[tex]= 0.5p_1 V_g[/tex]

when the block is floating, the weight supporting the force (buoyancy force) is:

W [tex]= 0.5p_1 V_g[/tex]

[tex]\rho Vg = 0.5p_1 V_g[/tex]

[tex]\rho = 0.5 \rho _1[/tex]

where;

water density [tex]\rho _1[/tex] = 1000

[tex]\rho = 0.5 (1000)[/tex]

[tex]\rho = 500 kg/m^3[/tex]

In the second liquid, the volume of plastic block in the water = (100-23)%

= 77% = 0.7 V

The force on the plastic block is:

[tex]= 0.77p_2 V_g[/tex]

when the block is floating, the weight supporting the force (buoyancy force) is:

[tex]W = 0.77p_2 V_g[/tex]

[tex]\rho Vg = 0.77 \rho_2 V_g \\ \\ \rho = 0.77 \rho_2 \\ \\ 500 = 0.77 \rho_2 \\ \\ \rho_2 = 500/0.77[/tex]

[tex]\mathbf{ \rho_2 \simeq 650 \ kg/m^3}[/tex]

What volume of each solution contains 0.14 mol of KCl? Express your answer using two significant figures.
1.8 M KCl

Answers

Answer:

Solution given:

1 mole of KCl[tex]\rightarrow [/tex]22.4l

1 mole of KCl[tex]\rightarrow [/tex]74.55g

we have

0.14 mole of KCl[tex]\rightarrow [/tex]74.55*0.14=10.347g

74.55g of KCl[tex]\rightarrow [/tex]22.4l

10.347 g of KCl[tex]\rightarrow [/tex]22.4/74.55*10.347=3.11litre

volume of each solution contains 0.14 mol of KCl contain 3.11litre.

[tex]\:[/tex]

1 mole of KCl → 22.4l

1 mole of KCl → 74.55g

we have

0.14 mole of KCl → 74.55*0.14=10.347g

74.55g of KCl  → 22.4l

10.347 g of KCl → 22.4/74.55*10.347=3.11litre

volume of each solution contains 0.14 mol of KCl contain 3.11litre.

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