Determine the effect each given mutation would have on the rate of glycolysis in muscle cells.

a. loss of binding site for fructose 1 ,6-bisphophate in pyruvate kinase.
b. loss of allosteric binding site for ATP in pyruvate kinase.
c. loss of allosteric binding site for AMP in phosphofructokinase.
d. loss of regulatory binding site for ATP in phosphofructokinase.

1. Increase
2. decrease
3. No effect

Answers

Answer 1

Answer:

a. Decrease

b. Increase

c. Increase

d. No effect

Explanation:

Glycolysis is present in muscle cells which converts glucose to pyruvate, water and NADH. It produces two molecules of ATP. Cellular respiration produces more molecules of ATP from pyruvate in mitochondria. Glycolysis increases in pyruvate kinase.

Answer 2

a. Loss of binding site for fructose 1,6-bisphosphate in pyruvate kinase: Decrease

b. Loss of allosteric binding site for ATP in pyruvate kinase: No effect

c. Loss of allosteric binding site for AMP in phosphofructokinase: Increase

d. Loss of regulatory binding site for ATP in phosphofructokinase: Increase

A. An important substrate in the glycolysis pathway is fructose 1,6-bisphosphate. It stimulates pyruvate kinase, an essential enzyme in glycolysis. The amount of pyruvate kinase that is activated will decrease if the fructose 1,6-bisphosphate binding site in pyruvate kinase is eliminated. As a result the rate of glycolysis in the muscle cells will probably decrease.

B. The allosteric ATP binding site of pyruvate kinase controls how active the enzyme is. However, pyruvate kinase is not significantly regulated by ATP in muscle cells. Therefore, it is unlikely that deletion of the ATP-binding allosteric site in pyruvate kinase would have no effect on the rate of glycolysis in muscle cells.

C. The rate-limiting enzyme in glycolysis, phosphofructokinase, is activated from all forms by AMP. It increases the rate of glycolysis by stimulating the activity of phosphofructokinase. If the allosteric binding site for AMP is eliminated, phosphofructokinase activation will be reduced. As a result, the rate of glycolysis in muscle cells will decrease.

D. Phosphofructokinase is inhibited allosterically by ATP. It regulates the rate of glycolysis by a feedback mechanism. High ATP concentrations cause phosphofructokinase to bind to its regulatory site, limiting its activity and delaying glycolysis. If the regulatory binding site for ATP is eliminated, the inhibitory action of ATP on phosphofructokinase would be lost. As a result, muscle cells will glycolysis at a faster rate.

Learn more about glycolysis, here:

https://brainly.com/question/26990754

#SPJ6


Related Questions

What is the molecular geometry of CIO3F as predicted by the VSEPR model?

Multiple Choice
trigonal pyramidal
square planar
square pyramidal
tetrahedral
octahedral

Answers

Explanation:

since there are no lone pairs on the central atom, the shape will be tetrahedral

A uniform plastic block floats in water with 50.0 % of its volume above the surface of the water. The block is placed in a second liquid and floats with 23.0 % of its volume above the surface of the liquid.
What is the density of the second liquid?
Express your answer with the appropriate units.

Answers

Answer:

density of second liquid = 650 kg/m³

Explanation:

Given that:

The volume of the plastic block submerged inside the water  = 0.5 V

The force on the plastic block  = [tex]\rho_1V_1g[/tex]

[tex]= 0.5p_1 V_g[/tex]

when the block is floating, the weight supporting the force (buoyancy force) is:

W [tex]= 0.5p_1 V_g[/tex]

[tex]\rho Vg = 0.5p_1 V_g[/tex]

[tex]\rho = 0.5 \rho _1[/tex]

where;

water density [tex]\rho _1[/tex] = 1000

[tex]\rho = 0.5 (1000)[/tex]

[tex]\rho = 500 kg/m^3[/tex]

In the second liquid, the volume of plastic block in the water = (100-23)%

= 77% = 0.7 V

The force on the plastic block is:

[tex]= 0.77p_2 V_g[/tex]

when the block is floating, the weight supporting the force (buoyancy force) is:

[tex]W = 0.77p_2 V_g[/tex]

[tex]\rho Vg = 0.77 \rho_2 V_g \\ \\ \rho = 0.77 \rho_2 \\ \\ 500 = 0.77 \rho_2 \\ \\ \rho_2 = 500/0.77[/tex]

[tex]\mathbf{ \rho_2 \simeq 650 \ kg/m^3}[/tex]

Consider the reaction: NaNO3(s) + H2SO4(l) NaHSO4(s) + HNO3(g) ΔH° = 21.2 kJ

How much heat must absorbed by the reaction system to convert 100g of NaNO3 into NaHSO4(s)?

Answers

Answer:

endet nach selam nw

4gh7

A chemical reaction in a bomb calorimeter evolves 3.86 kJ of energy in the form of heat. If the temperature of the bomb calorimeter increases by 4.17 K, what is the heat capacity of the calorimeter?

Answers

Answer:

925.66 J/K

Explanation:

Applying,

Q = CΔt............. Equation 1

Where Q = amount of heat, C = heat capacity of the calorimeter, Δt = rise in temperature.

make C the subject of the equation

C = Q/Δt.............. Equation 2

From the question,

Given: Q = 3.86 kJ = 3860 J, Δt = 4.17K

Substitute into equation 2

C = 3860/4.17

C = 925.66 J/K

What volume of each solution contains 0.14 mol of KCl? Express your answer using two significant figures.
1.8 M KCl

Answers

Answer:

Solution given:

1 mole of KCl[tex]\rightarrow [/tex]22.4l

1 mole of KCl[tex]\rightarrow [/tex]74.55g

we have

0.14 mole of KCl[tex]\rightarrow [/tex]74.55*0.14=10.347g

74.55g of KCl[tex]\rightarrow [/tex]22.4l

10.347 g of KCl[tex]\rightarrow [/tex]22.4/74.55*10.347=3.11litre

volume of each solution contains 0.14 mol of KCl contain 3.11litre.

[tex]\:[/tex]

1 mole of KCl → 22.4l

1 mole of KCl → 74.55g

we have

0.14 mole of KCl → 74.55*0.14=10.347g

74.55g of KCl  → 22.4l

10.347 g of KCl → 22.4/74.55*10.347=3.11litre

volume of each solution contains 0.14 mol of KCl contain 3.11litre.

Tick (√) the statements that are correct.

a) By eating rice alone, we can fulfil nutritional requirement of our body. ( )
b) Deficiency Diseases can be prevented by eating a balanced diet. ( )
c) Balanced diet for the body should contain a variety of food items. ( )
d) Meat alone. is sufficient to provide all nutrients to the body. ( )​

Answers

b) (√)

c)(✓)

hsjdhfjdkskkshd

Other Questions
Sometimes people say silly things they do not intend to be mean.Identify the choice that corrects this run-on sentence. . Using the identity (a + b) = (a + 2ab + b), evaluate 112 ANSWER AND ILL GIVE BRAINLIEST Which of the following statements can you infer would happen If one organ system stopped working?a. The other organ systems would have to work harder to make up for the broken system b. The other organ systems would stop working too.c. The other organ systems would still work on their own but might have to work harder to complete their function correctly. 5. Describe three ways that music can be used in television. (6 points) Which of the following pathways is most likely to be active in the adipocytes of a person with untreated type 1 diabetes?a. fatty acid synthesisb. glycogenolysisc. glycolysisd. lipolysis Isabel and Sophia share a bag of 42 sweets. Isabel has 16 sweets. Find the ratio of Sophia's sweets to Isabel's sweets. A sample of gas has a volume of 20 cm.The pressure is changed to 90 kPa at constant temperature,while the volume increases to 75 cm.What was the original pressure of the gas? How did early civilizations in the Americas differ from those in the Eastern Hemisphere? Does this graph show a function? Explain how you know.A. No; the graph fails the vertical line test. B. No; there are y-values that have more than one x-value. C. Yes; the graph passes the vertical line test.D. Yes; there are no y-values that have more than one x-value. Find the measure of What areas in Eurasia developed advanced civilizations first? What role did geography play in that development? Macronutrients is the most readily available for energy production Bird flu is not as lethal to humans as to the birds true or false Please Help Me! I will give brainly!! The distance from your front door to the mailbox is 18 4/5 meters. The distance from your front door to your basketball hoop is 13 7/10 meters. How much farther from your front door is the mailbox than the basketball hoop? On another map, the distance between Saugerties andKingston is 2 inches. What would the distance fromSaugerties to Catskill be on this map? What is the sum of the infinite geometric series? Find the equation of the line that contains the point (4, -2) and is perpendicular to the line y = - 2x + 5.y = 2x - 10y = - 2x + 6y = - 1/2xy = 1/2x - 4 Hlo gd evening allwhat is non-public proprietary Help what is xWhen x^5 is 225 1 pump can fill a pool in 8 hours the other pump can fill the pool in 10 hours if both of the pumps were turned on at the same time to fill the pool how long will it take