Further studies of the genes in the region around the MHC locus identified C4 as a likely causative gene. A particular allele of C4 was significantly associated with schizophrenia. In addition, it was found that individuals with high expression of this allele of C4 had elevated risk of developing schizophrenia. Which of the following variants would be most likely to increase risk of schizophrenia from this allele?

a. a variant that decreases binding of an activating transcription factor to the C4 promoter
b. a 5’ UTR variant that destabilizes the C4 mRNA
c. a duplication of the C4 gene
d. a nonsense coding variant

Answers

Answer 1

Answer:

c. a duplication of the C4 gene

Explanation:

Schizophrenia is a disease that affects the brain, which is characterized by an imbalance of neurotransmitters and the presence of damaged brain tissues. In humans, the Complement component 4 (C4) protein is found at the neurons (i.e., cell bodies, dendrites and axons), which are the most common brain cells, and neuronal synapses. Moreover, gene duplication can increase gene expression when repressive mechanisms (e.g., DNA methylation at promoter sites) capable of silencing the expression of the duplicated gene are lacking. Recently, it has been discovered that a chromosome rearrangement associated with a tandem duplication of a genomic region that contains a C4 gene may contribute to schizophrenia risk by increasing the expression of this gene​. In this example, a, b and d options are associated with a decrease in expression of the C4 gene, either by decreasing its transcription (options a and d) or by posttranscriptional mechanisms (option c).


Related Questions

Whic type of graph would you use if you wanted to see if one variable had an affect on another variable?

Answers

A scatter plot or scattergram chart will show the relationship between two different variables or it can reveal the distribution trends. It should be used when there are many different data points, and you want to highlight similarities in the data set.

Answer:

line

Explanation:

A line graph is used to see if there is a relationship between variables.

The continuity of life is based on heritable information in the form of DNA. Complete the explanation how mutations in protein-coding genes and regulatory DNA contribute to evolution. Match the terms in the left column to the appropriate blanks in the sentences on the right.
a. gene
b. silenced
c. reproduce
d. protein production
e. inherited
f. grows
g. body form
h. function
i. regulatory sequence
1. Mutations in protein-coding genes and regulatory DNA contribute to evolution if the organism carying them Survives and_____. Mutations in a____.
2. Mutations within a____may lead to major changes in______for example, ita Hox gene is attected. Moreover, if a transposable element inserts here, it may lead to a decreased or increased_____. This may impact the organism and if passed on to the offspring, become____. The result of these events may eventually lead to increased fitness and formation of new species.

Answers

Answer:

1. Mutations in protein-coding genes and regulatory DNA contribute to evolution if the organism carrying them survives and_c. reproduce. Mutations in a_a. gene lead to different effects. For example, a mutation may change the _h. function of the protein or the protein will no longer be produced.

2. Mutations within a_i. regulatory sequence may lead to major changes in_g. body form, for example, if a Hox gene is affected. Moreover, if a transposable element inserts here, it may lead to a decreased or increased_d. protein production. This may impact the organism and if passed on to the offspring, become_e. inherited. The result of these events may eventually lead to increased fitness and the formation of new species.

Explanation:

Mutations can be defined as genetic changes (nucleotide changes) in the genome sequence of an organism. Mutations can be beneficial, neutral or deleterious (depending on their effects on the adaptive fitness of the individual). Mutations that occur in the somatic (body cells) will not be inherited, whereas mutations in the germinal (gamete) cells can be passed on to the next generations. Moreover, Hox genes are major developmental regulators involved in a wide variety of aspects of animal development. In consequence, changes in the expression level of Hox genes caused, for example, through 1-mutations of their regulatory sequences, such as promoter sequences, or 2-the insertion of transposable elements, may lead to conspicuous phenotypic changes by affecting protein production. Eventually, these mutations may confer an adaptive advantage.

How will you isolate DNA from a pure fungal culture

Answers

Answer:

Explanation:

There are several ways of isolating DNA from a pure fungal culture but you can use the CTAB method.

In this method, genomic DNA can be extracted.

First of all, the cell walls of fungal mycelia can first be broken down by grinding it using glass rods or you can use or liquid nitrogen. Place it in a plate. You can now CTAB extraction buffer , then incubate at 65°C, then let it undergo purification with phenol:chloroform:isoamyl alcohol 25: 24: 1 and carry out precipitation with isopropanol . Then the DNA can be extracted and then dissolved in 50 μl of pure water.

What transmission pattern would indicate that a trait may be transmitted through X-linked inheritance

Answers

Answer:

The transfer pattern of an X-linked inheritance can be either X-linked dominant or X-linked recessive.

Explanation:

X-linked inheritance is the term that refers to a gene capable of causing a specific characteristic or disorder and is located on the X chromosome. During the transmission of genetic material for the formation of another living being, this gene can be transmitted through the transmission standards known as X-linked dominant or X-linked recessive.

X-linked dominance inheritance occurs when the dominant gene is transmitted on the X chromosome, while X-linked recessive inheritance occurs when the recessive gene is carried on the X chromosome.

my voice for safety advocacy in text ride or driver​

Answers

Answer:

I cannot help you with that because there is no question

The skin is protected by the action of cells that arise from bone marrow and migrate to the epidermis. Which cells serve this function?

Answers

Answer:

Langerhan's cells

Explanation:

The Langerhan's cells arise from the bone marrow and migrate to the epidermis. The Langerhan's cells are the body's first line of defense and play a significant role in antigen presentation. They need special stains to be visualized and are primarily found in the stratum spinosum. These are the mesenchymal origin obtained from CD34 positive stem cells of bone marrow and are part of the mononuclear phagocytic system.

Reviewing video surveillance is part of which alert food defense

Answers

Answer:

The correct answer is - look.

Explanation:

Alert is an acronym that is used in food defense that stands for Assure, Look, Employees, Reports, and Threat. It helps in increasing the awareness of food safety in food industries.

The Look is the type of alert that includes video surveillance in the food industry or store to check and maintain food safety and security. It helps in looking during and after the food defense.

The accurate solution is =look for is part of which alert food defense.

Alert is an acronym this is utilized in meals protection that stands for Assure, Look, Employees, Reports, and Threat. It facilitates in growing the attention of meals protection in meals industries.

The Look is the sort of alert that consists of video surveillance withinside the meals enterprise or shop to test and keep meals protection and security. It facilitates in searching in the course of and after the meals protection.

What is food defense?

Food protection is the safety of meals merchandise from infection or adulteration supposed to reason public fitness damage or financial disruption.

Thus it is well expailned.

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What are the products of photosynthesis?

Answers

Answer:

option C

Explanation:

Glucose and oxygen

Short-term mechanisms for regulating blood pressure include regulating peripheral vascular resistance and cardiac output through:________-

Answers

Answer:

Dilation or constriction

Explanation:

Short-Term mechanism for regulating blood pressure include regulating peripheral vascular resistance and cardiac output through dilation or constriction of the blood vessels while on the other hand, long-term mechanism for controlling of blood pressure done by the renin-angiotensin system. Brains stem is the part of the brain that is responsible for the controlling of blood pressure in the body.

Which of the following is a benefit of dams?

A. They impede fish migration and spawning

B. They provide a source of energy

C. They increase the sediment load of waterways


D. They divert water from ecosystems

Answers

A. They impede fish migration and spawning

Question 8 of 30
Which of these fields of study would be the most useful for someone
interested in preserving native plants in grasslands?
A. Meteorology
B. Botany
C. Chemistry
D. Anthropology
SUBMIT

Answers

Answer:

botany

Explanation:

since it deals with the study of plants

A solid reactant is placed into a beaker of a warm water. The liquid vigorously bubbles as the solid dissolves into the solution. What will most likely happen if the temperature of the liquid is slightly reduced?
More bubbles will be produced because the solution is becoming more concentrated.
Fewer bubbles will be produced because of fewer collisions of reactant molecules.
The solid will get smaller at a faster rate because of more collisions of reactant molecules.
The solid will get larger at a slower rate because precipitate is coming out of the solution.

Answers

Answer: Fewer bubbles will be produced because of fewer collisions of reactant molecules.

Answer:

B: Fewer bubbles will be produced because of fewer collisions of reactant molecules.

elaborate the value of wildlife

Answers

Answer:

1.Comm ercial Value- money made from wildlife and fish.

2.G ame Value- Value of wildlife as g ame.

3.Aesthetic Value- Value of wildlife for it's b b eauty and ple asure.

4.Scientific Value- Value placed on the study and res earch of wildlife.

5.they provides us food , clothing and source of income 

hope this will help you more..

how does hair appear on the head​

Answers

Explanation:

Blood from the blood vessels in your scalp feeds the root, which creates more cells and makes the hair grow. The hair gets pushed up through the skin as it grows, passing an oil gland along the way.

Answer:

Hair grows by forming new cells at the base of the root. These cells multiply to form a rod of tissue in the skin. The rods of cells move upward through the skin as new cells form beneath them. As they move up, they're cut off from their supply of nourishment and start to form a hard protein called keratin.

2. The process of obtaining and using energy is called
metabolism
O photosynthesis
reproduction
homeostasis

Answers

Answer:

metaboliam is the ans of this question

Which statement is true?

A.Peat is a fossil fuel because rewetting it takes only 3–5 years.

B.Peat is a fossil fuel because the total time for restoration is lengthy.

C.Peat is not a fossil fuel because it has biologic origins, making it a biofuel.

D.Peat is not a fossil fuel because humans can promote the replenishment of peat.

Answers

c. pear is not a fossil fuel because it has biologic origins making it a biofuel

Peat is not a fossil fuel because humans can promote the replenishment of peat is a correct statement.

What do you mean by Fossil fuels?

Fossil fuels may be defined as fuels that are derived from decomposed plants and animals. It includes coal, petroleum, oil, and natural gases.

Peat is considered forgotten fossil fuel because through the activity of humans it may be replenished into other forms for different use. It may maximum takes 3-5 years for rewetting.

Therefore, the true statement is Peat is not a fossil fuel because humans can promote the replenishment of peat.

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why are electrons in an atom involved in bonding

Answers

Answer:

The valence electrons have a role in the bonding of two atoms. The nuclei of each atom are drawn together by their attraction to the valence electrons of the other atom. As the atoms are drawn together by their attractions, electrons from each atom are drawn to the nuclei of both atoms, where they are "shared."

OAmalOHopeO

1. What features are located medial to the cranium and the mandible. Identify the category here.
2. How many individual items are included in this category?

Answers

The features that are located medial to the cranium and the mandible are:teeth,tongue, lips, chick hard andsoft palate,

   2. There is a total of six individual items in this category.

The human skull is made up of two parts, the cranium, which contains the face and the brain and the only movable bone called the mandible or lower jaw.

The features that are medial to the cranium and the mandible are those structures that are nearer to the mid-line.

The above mentioned features works together to provide the following functions of the cranium:

protection of the delicate structures including the brain, eye and the inner ear.maintaining patency of the nasal passage enabling breathing.the movement of the mandible allows chewing.

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.

What dose that mean please help

Answers

Explanation:

A = pi * r²

This is used to measure the area of a circle.

The value of pi is 22/7 or 3.14 and r is the radius of the circle.

Hope it helps :)

That’s the area of an entire circle

Predict what will happen to the concentration of pyruvate, NADH and H+ when the Krebs cycle is stopped by arsenic

Answers

Answer: Pyruvate would increase, NADH would decrease, and intermembrane H+ would decrease as well.

Explanation:

Glycolysis would raise pyruvate, but the Krebs Cycle would not produce NADH, decreasing it. No protons (H+) will be pushed into the intermembrane gap, lowering its H+ content and raising its pH.

What is Kreb's cycle?

The tricarboxylic acid (TCA) cycle, commonly referred to as the Krebs cycle or the citric acid cycle, is the primary route that cells use in order to acquire energy and is an essential component of aerobic respiration. The cycle transforms the oxidative potential of acetyl coenzyme A (acetyl CoA) into the reductive potential of nicotinamide adenine dinucleotide (NADH).

The synthesis of ATP via the Krebs cycle is disrupted when arsenic is present because it prevents pyruvate from being converted into acetyl coenzyme A (acetyl-CoA). In addition to the effects described above, arsenic also prevents glucose uptake at the cellular level, as well as gluconeogenesis, the oxidation of fatty acids, and additional acetyl-CoA formation.

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Question 2 of 26
What happens at a subduction zone between an oceanic plate and a
continental plate?
O A. The continental plate slides under the oceanic plate, and
part of it melts to form magma that sinks into the mantle.
O B. The oceanic plate and continental plate pull away from
each other, allowing magma to rise and form an ocean
ridge.
O c. The oceanic plate and continental plate slide past each
other, creating a series of faults that allow magma to rise
and form a chain of volcanoes.
O D. The oceanic plate slides under the continental plate, and
part of it melts to form magma that rises up through the
continental plate.
SUBMIT

Answers

D. The oceanic plate is more dense and will slide under the continental one

Would an observational study or an experiment be more appropriate to investigate the effects on fertilizer on plant growth? Explain.

Answers

Answer:

Experiment

Explanation:

For such an investigation an Experiment would be the better option. This is because in an experiment you would have both an experimental group and a control group. This would allow you to use fertilizer on one but not the other, therefore, providing seperate results that you can use to compare with one another. This ultimately helps you determine the actual effects that fertilizer has on the growth of plants, since the fertilizer would be the only variable in the experiment. An observational study would only allow you to observe the plants in a natural scenario, without interfering and seperating the plants into different groups with different environments.

In pea plants, flowers are either white or purple: the purple color is produced by pigments called anthocyanins. The production of anthocyanins is a two-step process: the first step is controlled by the C gene and the second by the P gene. Both genes must produce functional proteins for anthocyanin to be produced. This is an example of:

Answers

Answer:

This is an example of gene translation.

Explanation:

Gene translation refers to the genetic process where a set of genes is used to create amino acids that will be responsible for creating a protein needed to perform some function or characteristic of the organism. In the question above, we can see that anthocyanin, responsible for the pigment of flowers, is created through the work of proteins that are created from gebes C and P. This is an example of gene translation, as it presents the formation of proteins regulated by genes.

What is added to tacos, burritos, and soups that is
high in fiber?

Answers

Answer: flax seed whole wheat tortillas.

1⁄2 cup low-fat refried beans.

1⁄4 cup low-fat cheddar cheese.

leaves lettuce.

1⁄ cup salsa.

1⁄4 cup fat free sour cream.

Pinto beans are added to tacos, burritos, and soups that are high in fiber.

What are fibers and their types?

The body is unable to digest fiber, which is a form of carbohydrate. While fiber cannot be converted into glucose, the sugar that results from the breakdown of most carbs, fiber travels through the body undigested.

The solubility, viscosity, and fermentability of dietary fibers, which have an impact on how they are metabolized by the body, can be used to classify them in general. Dietary fibers have a wide range of chemical compositions.

Fibre comes in two varieties: soluble and insoluble. Both are crucial for good health, digestion, and illness prevention. Thus, Pinto beans are added to tacos, burritos, and soups that are high in fiber.

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How are meiosis and mitosis similar?



A.They both produce diploids.

B.They happen at the same time.

C.They both produce sex cells.

D.They both produce new cells.

Answers

Answer:

D.They both produce new cells.

Explanation:

Meiosis and mitosis are both processes of cell division; however, they have many differences. Meiosis occurs in sex cells and produces haploids that can be fertilized. Mitosis occurs in body cells and produces diploids that replace old or damaged cells. Still, both processes result in the creation of new cells.

Answer:

D) They both produce new cells!

Explanation:

Dont forget to give a thank you, and to rate my answer!

Provide details about Meiosis.

Answers

Explanation:

a type of cell division that results in four daughters cells each with half the numbers of chromosomes of the parent cell , as in the production of gametes and plant spores

the prime mover of inspiration is the blank during normal quiet breathing expiration is a passive process as this muscle relaxes into its original dome shape. provide conditions when expiration becomes an active process or forced. explain

Answers

Answer:

The prime agonist of inspiration is the diaphragm muscle.

The conditions when expiration becomes an active process is : Emphysema, Pneumonia, Bronchitis.

-Expiration is the passive process as there is elastic recoil of lungs following inspiration without contraction of any muscles.

-The elastic fibers in alveoli are damages or filled with mucus and fluid in the disease such as conditions such as emphysema or pneumonia.

-Elastic recoil of lungs.

-Hence, muscle contraction is required to forcefully exhale the air from lungs. Internal intercostal muscles contract to pull the ribs downward and remove air from the lungs.

In which process do producers use chemi-
cal energy and make food?
A chemosynthesis
B fermentation
C glycolysis
D photosynthesis

Answers

Answer: D, Photosynthesis

Explanation:

photosynthesis is the process plants use to make food :)

assertion: empty milk pouches are biodegradable Reason: they cannot be used in biogas formation​

Answers

Answer:

The pollutants like heavy metals, organic solvents present in pesticides exist in small amounts in the atmosphere. During the process of the food chain, the concentration of these pollutants progressively keeps on increasing through different trophic levels. For example, fish eats a lot of planktonic growth may retain the pollutants in their tissues, birds or people that eat the fish might concentrate the pollutants still more. This process of accumulation of pollutants at different trophic levels is called as biomagnification. So, the correct answer is 'Assertion is correct but Reason is incorrect'.

Identify the phases of meiosis I described below

Answers

Since cell division occurs twice during meiosis, one starting cell can produce four gametes (eggs or sperm). In each round of division, cells go through four stages: prophase, metaphase, anaphase, and telophase.
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