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2. Complete the following chart about the three main research projects
that led to the identification of DNA as the genetic material.
RESEARCHERS' NAMES
SUMMARY OF RESEARCH
SUMMARY OF CONCLUSIONS
Griffith
found a "transforming principle"
Avery
Hershey and Chase
identified the substance that phages inject
into bacteria

Answer:

Griffith's experiment, reported in 1928 by Frederick Griffith, was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation. Griffith's findings were followed by research in the late 1930s and early 40s that isolated DNA as the material that communicated this genetic information.

Griffith's experiment discovering the "transforming principle" in pneumococcus bacteria.

Pneumonia was a serious cause of death in the wake of the post-WWI Spanish influenza pandemic, and Griffith was studying the possibility of creating a vaccine. Griffith used two strains of pneumococcus (Streptococcus pneumoniae) bacteria which infect mice – a type III-S (smooth) which was virulent, and a type II-R (rough) strain which was nonvirulent. The III-S strain synthesized a polysaccharide capsule that protected itself from the host's immune system, resulting in the death of the host, while the II-R strain did not have that protective capsule and was defeated by the host's immune system. A German bacteriologist, Fred Neufeld, had discovered the three pneumococcal types (Types I, II, and III) and discovered the quellung reaction to identify them in vitro. Until Griffith's experiment, bacteriologists believed that the types were fixed and unchangeable, from one generation to another.

In this experiment, bacteria from the III-S strain were killed by heat, and their remains were added to II-R strain bacteria. While neither alone harmed the mice, the combination was able to kill its host. Griffith was also able to isolate both live II-R and live III-S strains of pneumococcus from the blood of these dead mice. Griffith concluded that the type II-R had been "transformed" into the lethal III-S strain by a "transforming principle" that was somehow part of the dead III-S strain bacteria.

Completing the attached chart about the three main research projects ;

All three researches were carried out to discover the genetic material ( DNA ) which is responsible for the transfer of genetic traits from parent cells to daughter cells.

Griffith research shows that bacterias can get there DNA ( genetic material ) through a process known as transformation and the experiment to prove this research was carried out by killing S bacterias through heat and then adding them to R-strain bacteria. Griffith observed and concluded that the Genetic materials of the S bacteria was taken up by the S -bacterias through a process known as " transforming principle "

During Avery research for the genetic material ( DNA ) Avery treated a mixture with DNA-destroying enzymes to see if the colonies of the mixture will transform but they failed to transform which proves that proteins are not the transforming factors and that DNA is the genetic material.

Hence we can conclude that Completing the attached chart about the three main research projects is as written above.

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