Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?
A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes

Answers

Answer 1

Answer:

C) proteins with gain-of-function mutations

Explanation:

Gain-of-function mutations: In biology, the term "gain-of-function mutation" is described as one of the different types of mutation in which the altered or changed "gene product" consists of an entirely new pattern or molecular function associated with gene expression. However, the "gene-of-function mutations" are being always considered as "Semidominant or Dominant".

In the question above, the correct answer is option C.


Related Questions

Where does that air go as a result?

Answers

Answer:

Air go from one place to another due to difference in temperature of land and sea.

Explanation:

Air go as a result of wind from one place to another. Air moves from land to sea is called land breeze and from sea to land is known as sea breeze. This will occur when there is difference in temperature between sea and land. Sea breeze occurs at afternoon while land breeze occurs at night till morning. Warm air produces low pressure and cold air produces high pressure so when warm air rises, cold air takes its place and this cycle continues.

The relative value of grains for animals is determined primarily by metabolizable energy and crude protein content. From the information below, which grain is the best choice for feeding swine?Grain Crude Protein Metabolizable Energy $ Per TonBarley 13.00% 3.000 kcal/kg 170Corn 10.00% 3.600 kcal/kg 160Grain sorghum 12.00% 3,200 kcal/kg 140Wheat 14.00% 3,400 kcal/kg 180

Answers

Answer:

Corn

Explanation:

Good news for corn and soybean hog growers because these two grains are the main ingredients in pork diet and these feedstuffs should be affordable.   According to metabolism, corn has the highest metabolic energy, i.e. 3600 k.cal/kg                Therefore, corn is the best food for swin  so, the correct answer is corn.  


Evidence without_______
increases its reliability.
a
bias
b
question
с
repetition
d
replication

Answers

Answer:

I'll say its B ) Question

Explanation:

because when your proving something with evidence then you start asking questions (or still have questions) makes it seem like you don't really know.

Assume that you have an antimicrobial agent specific for each of the targets listed below. Indicate which type of microbe would be most susceptible to the agent.
A. All bacteria
B. Gram-positive bact.
C. Gram-negative bact.
D. Viruses
E. All bact. and viruses

Answers

Answer is given below

Explanation:

If you have an antimicrobial agent specific for each of the targets listed below

all bacteria -                     glycolytic enzymes and membrane proteinsgram-positive bacteria -   peptidoglycanGram-negative bacteria   ceftiaxon, cefpodoximeviruses -                             envelope proteinsall bacteria and viruses -   nucleic acids

What is the wavelength of an earthquake wave if it has a speed of 10 KM/S and a frequency of 5HZ?

Answers

Answer:

2nm

Explanation:

(10KM/S)/(5HZ) = 2nm

When brown iodine is exposed to starch it turns dark purple. In an experiment, you placed a cornstarch solution in a small plastic bag. Next, you placed the bag in a beaker of water containing 10 drops of iodine. If the solution in the plastic bag turned dark purple (Select all that apply)
a) the plastic bag was permeable to cornstarch.
b) the plastic bag was permeable to iodine.
c) the iodine moved into the plastic bag.
d) the cornstarch moved into the beaker.
e) the plastic bag was selectively permeable.

Answers

Answer:

b) the plastic bag was permeable to iodine

the plastic bag was selectively permeable

the iodine moved into the plastic bag.

the plastic bag was permeable to cornstarch.

Explanation:

The experimental set up represented the concept of osmosis.That is  the movement of water  molecules from the region of higher  water potential to region of lower water potential through a semipermeable membrane(a  cell membrane which only allows water and certain molecules to pass through,but restrain other molecules through its pores.

Generally potassium iodine test is the standard test for starch.

Therefore, in the question,water moves iodine molecules as iodine solution(from high water potential) to move across the paper bag(semi permeable membrane) to the reach the corn solution.(low water potential,high solute potential).This turns the starch in the corn solution  blue-black/purple.

If the solution in the plastic bag turned dark purple:

the plastic bag was permeable to iodine. That is option (B)the iodine moved into the plastic bag.  That is option (C)the plastic bag was selectively permeable.  That is option (E)

To test for the presence of starch in a solution, iodine solution is used. This gives a blue-black coloration which occurred due to the formation of a starch-iodine complex.

From the above experiment, the plastic bag which contains the corn starch solution, separates the solution from water containing 10 drops of iodine.

The turning of the solution, inside the plastic bag, into blue black signifies the formation of starch-iodine complex between the cornstarch solution the iodine water.

The reaction was able to occur because the plastic bag, which is selectively permeable to iodine, allowed the movement of iodine from the beaker of water into it. This is called diffusion.

Therefore, if the solution in the plastic bag turned dark purple it means that the plastic bag which is semi permeable allowed the movement of iodine into it.

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The first place that the reabsorption of water is not automatically coupled to the reabsorption of filtered solutes occurs in the PCT.

a. True
b. False

Answers

Answer:

False

Explanation:

The correct answer is false because Reabsorption of water and other filtered solutes like vitamins, sodium e.t.c. take place in the proximal convoluted tubules.

Reabsorption is when water and solutes in the PCT are removed and moved back into the blood and it's a process that take place through bulk transport.

The solutes and water are transported from the PCT to the interstitium and then move into peri-tubular capillaries and reabsorption in PCT is isosmotic i.e solutes have the same osmotic pressure.

Under normal conditions glomerular filtration depends on three main pressures. What pressures is a pressure that favors the process of filtration?

Answers

Answer:

Glomerular Hydrostatic pressure .

Explanation:

The basic function of the kidney is the formation of urine for elimination through the urinary excretory system. Two different processes determine this formation: the filtration of fluid through the glomerular capillaries into Bowman's space and the modification of the volume and composition of the glomerular filtrate in the renal tubules.  The fluid passes from the glomerular capillaries to Bowman's capsule due to the existence of a pressure gradient between these two areas. This process is favored by two structural characteristics that make renal corpuscles particularly effective filtration membranes: glomerular capillaries have a much higher number of pores than other capillaries, and the efferent arteriole has a smaller diameter than the afferent arteriole, causing greater resistance to outflow of blood flow from the glomerulus and increasing glomerular hydrostatic pressure. Increased glomerular hydrostatic pressure (due to increased blood flow through the glomerulus) increases filtration, while increases in Bowman's hydrostatic pressure or urinary space (which remains constant, unless there is disease at that level, usually due to fibrosis) and plasma P. oncotic (determined by proteins, which tend to "drag" plasma into the glomerulus) decrease filtering. Resulting in a filtering pressure of 10 mmHg.

​"Acidic" is an appropriate description for four of the following. Which one is the exception?

A). Soup and ammonia

B). HCI

C). Excess hydrogen ions

D). The contents of the stomach

E). A pH less then 7

Answers

Answer:

E) A pH less than 7

Explanation:

if a solution has a higher concentration of hydronium ions than pure water , it has a pH lower than 7

Answer: e

Explanation:

I did the test

C. If you combined the elements in the product of this reaction, what type of

reaction would it be? Hint: What is the reverse of the equation you just

balanced? (1 point)

Answers

Answer:

Reversible reaction

Explanation:

If the elements of the product combine together in a chemical reaction, this reaction is called reversible reaction because the reaction moves in backward  or reverse direction. For example, if acid i. e. HCl combine with base i. e. NaOH which are the reactants, it produces two products salt (NaCl) and water (H2O). If salt (NaCl) and water (H2O) combine again with each other, it produces acid i. e. HCl and base i. e. NaOH, such type of reaction is called reversible reaction.

Are bacteria eukaryotes

Answers

Answer:

yes they very much are!!!!!!!!!

The correct sequence for western blotting is:

1. Proteins are denatured by sodium dodecyl sulfate (SDS), and by boiling.
2.Transfer proteins to the nitrocellulose membrane.
3. Performing the polyacrylamide gel electrophoresis (PAGE).
4. Incubate the nitrocellulose membrane to primary antibodies and secondary antibodies subsequently.

a. 1,2,3,4
b. 4,1,3,2
c. 1,3,2,4
d. 1,3,2,4

Answers

Answer:

3.page is this that answer

Explanation:

a.1,2,3,4

The correct sequence for western blotting is: C. 1,3,2,4

Blotting can be defined as an analytical technique that is designed for the analysis of biological macromolecules such as:

Lipids.Nucleic acid.Proteins.Carbohydrates.

For western blotting, the correct sequence of analyzing biological macromolecules such as proteins is:

1. The denaturation of protein through the use of sodium dodecyl sulfate (SDS) and by boiling.

2. The performance of polyacrylamide gel electrophoresis (PAGE).

2.The transfer of proteins to the nitrocellulose membrane.

4. Lastly, the incubation of the nitrocellulose membrane to subsequently form primary antibodies and secondary antibodies.

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If the gametes from a diploid individual only contain one of the two possible alleles, it is not difficult to determine the genotypes of the gametes from that individual. For the diploid genotypes indicated below, write all of the possible genotypes of the gametes. If more than one type of gamete is possible, separate them with a comma. Diploid Genotype Genotype of Gametes RR rr Rr

Answers

Answer:

Diploid Genotype - Genotype of Gametes

RR - R

rr - r

Rr - R, r

Explanation:

According to Gregor Mendel in his law of Segregation, he stated that the alleles of a gene gets separated into gametes during gamete formation (meiosis). This occurs in such a way that only one allele of the two possible alleles that make up the genotype of a diploid organism is found in the gamete.

Meiosis is a cell division that reduces the chromosomal number of the daughter cells. Hence, a diploid organism (2n) will undergo meiosis to produce haploid (n) daughter cells (gametes). An organism with a diploid genotype RR will produce gametes which have only genotype R. The same applies to organism with genotype rr. Only gametes with genotype, r, will be produced.

However, in a heterozygous genotype like Rr, the different alleles will separate into gametes in an equal proportion i.e. gametes with genotypes R and r will be produced in a ratio 1:1.

Enzymes are protein molecules which are made up of long chains of

Answers

They are made up of amino acids

if a short sequence of dna reads 3'TAACGTCCAGGCAAA5', what is the complementary sequence in the other strand of dna g

Answers

Answer:

5' ATTGCAGGTCCGTTT 3'

Explanation:

Complimentary strands of DNA run anti-parallel to each other, the ends facing in opposite directions.

The complimentary base pairs for DNA are:

A=T and C=G and when finding the complimentary strand these pairs are only paired with each other.

Is it normal to have two baby fish that are stuck together?

Answers

Answer:

No its not

Explanation:

Hey there!

Conjoined fish is a very rare occurrence that does not happen often.

Hope this helps :)

The most abundant element in the body of living things is: a) Hydrogen b) Nitrogen c) Carbon d) Oxygen​

Answers

Answer:

D. Oxygen

Explanation:

Oxygen is the most abundant element in the bodies of living things. For example, oxygen is about 65% of the human body.

Oxygen in the body is mostly in the form of water, since the bodies of living things need water to create energy needed every day.

whats the biggest mystery about the virus​

Answers

Explanation:

Hey, there!!

According to what i have learned, the biggest mystery about virus is; It acts like both living and non- living beings.

living characters includes :

It reproduce to make more no. of themselves. It feeds on various substances.

non- living characters:

It can be crystallize. It dont respire and feed eith it is out from a host body.

Hope it helps...

what are some questions an environmental biologist might ask about qhat they are studying

Answers

they could ask what biology is? what the meaning of biology us?

What is the maximum magnification of most classroom compound light microscopes? 500x 1,000x 2,500x 5,000x

Answers

Answer:

2,500x

Explanation:

am doing the review rn

Answer:

1,000x

Explanation:

i got yall

4
THE EAR
4.1
4.1.1 Which ONE of the following is a part of the ear where grommets
are inserted?
A Oval window
B Semi-circular canal
C Tympanic membrane
Pinna
noreen with middle ear infection is usually advised not to fly in an

Answers

Answer:

C

Explanation:

Zlrozdzidkzzkxhkcgkxtkckgcgkckzxtixkgx

Following antigenic stimulation, phosphorylation of _________ relieves inhibition of the transcription factor

Answers

Answer: zap70, ITAM.

Explanation:

An antigen is any substance that is capable of stimulating an immune response by activating lymphocytes, which are the body’s infection-fighting white blood cells. Examples of antigens could be proteins that are part of bacteria or viruses or components of serum and red blood cells from other individuals, all of them are foreign antigens originated outside the body. However, there can also be autoantigens (which are self-antigens), originated within the body. In normal conditions, the body is able to distinguish self from nonself. And the antigens that represent a danger induces an immune response by stimulating the lymphocytes to produce antibody or to attack the antigen directly. This is called an antigenic stimulation of the immune system.

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein that is part of the T cell receptor, thereby it plays a critical role in T-cell signaling. When the TCR (receptor of T cells) is activated by the presentation of the specific antigen through the MHC, a protein called Lck acts to phosphorylate the intracellular CD3 chains and the ζ chains of the TCR complex, allowing the binding of the cytoplasmic tyrosine kinase, ZAP-70. Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as an anchor site for several other proteins. The tyrosine phosphorylation cascade initiated by the Lck culminates in the intracellular mobilization of calcium ion (Ca2+) and the activation of important signaling cascades within the lymphocytes. These include the Ras-MEK-ERK pathway, which is based on activating certain transcription factors such as NFAT, NFκB and AP-1. These transcription factors regulate the production of of certain gene products, most notably cytokines such as interleukin-2 that promote the long-term proliferation and differentiation of activated lymphocytes.

The ITAM motifs (immunoreceptor tyrosine-based activation motif) are sequences of four amino acids present in the intracellular tails of certain proteins that serve as receptors within the immune system. Thus, some receptors such as the TCR have ITAM sequences that, when activated, trigger an intracellular reaction based on consecutive phosphorylations.  Kinases are recruited for this purpose.

So, ZAP-70 is a protein tyrosine kinase with a role in T-cell receptor signal transduction. During T-cell activation, ZAP-70 binds to ITAM and becomes tyrosine phosphorylated. The binding of ZAP-70 to the phosphorylated ITAM is able to activate its kinase activity, and relieves the inhibition of the transcription factor which regulates genes that are involved in the immune reaction.

Place the respiratory structures into the order that air would pass through them during a normal inspiration.
Outside of Body
1. nares
2. vestibule
3. nasal cavity
4. choanae
5. nasopharynx
6. oropharynx
7. laryngopharynx
8. larynx
Inside of Body

Answers

Answer:

Outside of the body, nares, vestibule, nasal cavity, choanae, nasopharynx, oropharynx, laryngopharynx, and larynx.

Explanation:

During inspiration, the air enters through the nares in the nose.  From here, it goes up passing through the vestibule, the nasal cavity, and the choanae to start descending through the pharynx. The pharynx has three parts: the nasopharynx, which is in contact with the nose; the oropharynx that is in contact with the mouth; and the laryngopharynx, which is in contact with the larynx and esophagus. Between the oropharynx and laryngopharynx is the epiglottis, this is cartilage that prevents food from going to the lungs when we swallow food. After passing through the pharynx, the air flows through the larynx. From here, the air goes to the trachea, the bronchi, which enters the lungs giving the bronchioles, and these divide giving the alveolus, which is the place where the exchange of Oxygen and Carbon dioxide occurs.              

Placing the respiratory structures in the correct order :

Outside of  Body --> nares --> vestibule --> nasal cavity --> choanae --> nasopharynx --> oropharynx -->  laryngopharynx --> larynx -- > inside of body

During respiration the air enters from outside of the body into the body through the nares down to the vestibule, the nasal cavity which will descend down through to the pharynx which is further divided into three ( 3 ) parts which are; nasopharynx,  oropharynx, and laryngopharynx. The epiglottis is located between oropharynx and laryngopharynx.

Hence we can conclude that Placing the respiratory structures in the correct order ; Outside of  Body --> nares --> vestibule --> nasal cavity --> choanae --> nasopharynx --> oropharynx -->  laryngopharynx --> larynx

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Paleobiologists generally recognize the five most severe mass extinctions during the Phanerozoic Eon. Along with the other students in this class, determine when each of these “Big Five” mass extinctions occurred. Include in the discussion a brief list of which organisms went extinct during each of these events and which organisms radiated afterwards. You should use the information from this unit and from Internet searches to help you in this discussion. NO plagiarism will be permitted.

Answers

Extinction of the Ordovician: This extinction was responsible for the disappearance of about 60-70% of the species of oceanic life, This is because in that period most of the life on Earth was in the ocean. This extinction is believed to have been caused by an intense glacial period, although short that froze most of the planet's water. It is believed that the species most affected were sponges, algae, jawless fish, molluscs and cephalopods.

Devonian Extinction: Responsible for the disappearance of about 75% of marine species. This extinction was caused by the depletion of oxygen in the ocean, making life impossible for all aerobic marine organisms. This depletion of oxygen was caused mainly by the variation in the level of the ocean and climatic changes that may have been caused by asteroids.

Permian Extinction: Responsible for the death of 95% of life on earth. This extinction is known as the "mother of all extinctions" due to its destructive character, which devastated life on land and in the ocean. It is believed that this extinction was caused by volcanic activities triggered by the impact of asteroids. Almost all living species on earth were affected, such as insects, trilobites, sharks, boneless fish, reptiles, among others.

Extinction of the Triassic: It is not known exactly what caused this extinction, but it is estimated that it had the power to decimate 70-80% of terrestrial life, mainly arcosaurs and amphibians. The most accepted theory today is that the extinction was caused by recurrent volcanic activities that influenced huge volumes of carbon dioxide in the atmosphere, generating intense heating.

Cretaceous extinction: It was caused by the impact of an asteroid with the earth. The impact had the power to exterminate 75% of terrestrial life. This is the most well-known extinction, since it was responsible for decimating dinosaurs, however, some animals survived this impact, such as most marine species, frogs, birds, reptile and mammals.


Explain in detail if the water molecule (top) can interact with the glucose molecule (bottom)

Answers

Answer:

Yes, glucose dissolves in water.

Explanation:

Hello,

In this case, we can state that glucose is largely soluble in water due to the fact that it has five of polar hydroxyl groups which can interact with the hydrogen atoms in the water throughout the hydrogen bonds. Such hydrogen bond is known as an intermolecular force that forms a special type of dipole-dipole attraction when a hydrogen atom bonded to a strongly electronegative atom (like the oxygen in the hydroxyl groups) exists in the vicinity of another electronegative atom with a lone pair of electrons, therefore they occur among molecules.

The levels of nitrogen and ___ in the atmosphere remain fairly constant but the levels of other gases may vary.

Answers

Answer:Oxygen

Explanation:

Keeping in mind that a crayfish is saltier than the fresh water it occupies, and remembering the idea of osmosis, note that the antennal gland deals directly with the consequences of this issue. What do you suppose the function of the antennal gland is

Answers

In the antennal gland of the freshwater crayfish (Astacus), fluid is filtered from the blood into an end sac and passes through a tubular labyrinth, where ions are reabsorbed, to produce a hypotonic urine that passes via a renal tubule to the bladder.

A student did an experiment with two identical fish tanks, Tank 1 and Tank 2. About 20 ml water purifier was added to Tank 1 and 10 ml
water punfier was added to tank 2. Tank 1 was heated to 88° F and Tank 2 was left at room temperature. The water purity of each tank was
tested every day in particles per liter. The purity was recorded over a period of 5 weeks in the table shown below.
Week Water Purity of Tank 1 Water Purity of Tank 2
12.6
12.6
13.7
13.9
14.3
14.4
15.7
15.8
17.6
17.6
Based on the table, which of these conclusions is correct?

a

Fish need 10 mL of water purifier to survive.

b

More purifier is needed to keep heated water clean.

с

Water purifier can help a fish survive longer.

d

Water purifier keeps fish tanks clearer for longer.

pleasee helppp !!​

Answers

Answer:

a . Fish need 10 ml of water purifier to survive.

Explanation:

Fish need 10 ml of water purifier to survive because the data of 10 ml and 20 ml purifier is the same so it is recommended to use 10 ml purifier. First the data was same but by recording next week data, it shows slightly increase in the value of tank 2 while in the last week, both has the same value so we can concluded that by using 10 ml purifier is enough for the fish to survive.

Answer:

Its B/More purifier is needed to keep heated water clean.

Explanation:

The best fossil evidence to suggest that Neandertals could produce a language like that of modern humans comes from which bone(s) collected at Kebara, Israel?
a. the hyoid
b. the mandible
c. the cervical(neck) vertebrae
d. the ribs

Answers

Answer:

The answer is A.

Explanation:

The best fossil evidence that suggests Neandertals' ability to produce a language like modern humans comes from the hyoid bone.

This bone is located in the neck between the chin and the thyroid, which is also named "tongue bone" or "language bone".

So the correct answer is A.

I hope this answer helps.

what are biogeochemical ?​

Answers

Biogeochemical cycle, any of the natural pathways by which essential elements of living matter are circulated. The term biogeochemical is a contraction that refers to the consideration of the biological, geological, and chemical aspects of each cycle.
Other Questions
Now considering the real world situation are there any restrictions or changes you need to make for your domain or range to fit the situation described above? If so adjust your graph to represent these changes. Considering the real situations above (Question D.) 105/22 (1.251 - 0.620)= Which enzyme is used in gluconeogenesis, but NOT in glycolysis? Group of answer choices PEP carboxykinase enolase (interconverts 2-phosphoglycerate and phosphoenolpyruvate) Some of the most common applications of real options are with property and insurance. A real estate option grants the holder the right to buy or sell a piece of property at an established price sometime in the future. If the price of the property goes _____, the owner of the option is likely to buy it. If the market value of the property ______ the strike price, the option holder is unlikely to execute the purchase. You have a lightweight spring whose unstretched length is 4.0 cm. First, you attach one end of the spring to the ceiling and hang a 1.8 g mass from it. This stretches the spring to a length of 5.2 cm . You then attach two small plastic beads to the opposite ends of the spring, lay the spring on a frictionless table, and give each plastic bead the same charge. This stretches the spring to a length of 4.8 cm .Required:What is the magnitude of the charge (in nC) on each bead? in the mid 1800s notherners used the term slave power to criticize what they believed to be the excessive political influence of which groups of people? Plzzz Help plzzIs the following Triangle a right triangle If, Not what type of triangle (acute or obtuse) is it? Show your work! 3,4,6 THIS IS THE HARDEST WORK ON EART SOMEONE HELP ME Which are features of myths? Check all that apply. 1 supernatural gods or animals 2 fantastic settings 3 humorous elements that entertain the reader 4 an attempt to explain the origin of the universe 5 characters found in everyday life 6 conflicts between worlds, beings, self, or natural elements 7 everyday events WILL GIVE 100 POINTS If that voice sounds true, don't thank me. Thank that great horned owl. (Or perhaps it was not an owl after all?) And thank the children, my own and others, who have never forgotten that a good story can be true. For they understand that the power of imagination is truly the power of creation. Which of the following is implied in the paragraph? The author doesn't want the reader to thank the horned owl for voice. The author doesn't think voices can be true. The author believes that some people forget about the power of imagination. The author believes imagination and creation are connected. Operations that a given computing agent can perform are called Suppose that X; Y have constant joint density on the triangle with corners at (4; 0), (0; 4), and the origin. a) Find P(X < 3; Y < 3). b) Are X and Y independent consider a bond that matures in 10 years it pay9% annual coupons and $100 at maturity is the required annual rate of return on the bond i s 8% then the bond will sell today for 3. Can you make an inference without having made observations? Geraldo recently saw a newspaper ad for a new version of his laptop. The projected price is $400.00, and the laptop will be out on the market in about one year. Geraldo wants to purchase a new laptop but is wondering if he should wait a year. With 2.5% inflation, what amount would he pay to purchase a laptop today that is the same value as the one he saw in the ad? What is the main idea of Negore, the coward? what was the significance of the papacy of Avignon? what mode of nutrition is house fly 24. After a vertical reflection across the x-axis, f(x) is Options: A. f(x) B. f(x 1) C. f(x) D. f(x) Ready Company has two operating (production) departments: Assembly and Painting. Assembly has 280 employees and occupies 55,200 square feet; Painting has 120 employees and occupies 36,800 square feet. Indirect factory expenses for the current period are as follows: Administration $ 86,000 Maintenance $ 102,000 Administration is allocated based on workers in each department; maintenance is allocated based on square footage. The total amount of indirect factory expenses that should be allocated to the Painting Department for the current period is: