marco mr, zhou l, patil s, marcet je, varma mg, oommen s, et al. consolidation mfolfox6 chemotherapy after chemoradiotherapy improves survival in patients with locally advanced rectal cancer: final results of a multicenter phase ii trial. dis colon rectum. 2018;61(10):1146-55.

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Answer 1

The given information is a citation for a research paper titled "Consolidation mFOLFOX6 chemotherapy after chemoradiotherapy improves survival in patients with locally advanced rectal cancer: final results of a multicenter phase II trial." The paper was published in the journal "Diseases of the Colon & Rectum" in 2018.

The study investigated the effects of consolidation chemotherapy with mFOLFOX6 after chemoradiotherapy in patients with locally advanced rectal cancer. The final results showed that this approach improved survival in these patients. The citation provides the title of the research paper: "Consolidation mFOLFOX6 chemotherapy after chemoradiotherapy improves survival in patients with locally advanced rectal cancer: final results of a multicenter phase II trial."It mentions the authors of the paper: Marco MR, Zhou L, Patil S, Marcet JE, Varma MG, Oommen S, et al. The citation includes the name of the journal where the paper was published: Diseases of the Colon & Rectum.

The year of publication is mentioned: 2018. The citation provides the volume and issue number of the journal: 61(10). It includes the page numbers of the paper: 1146-55. The given citation is a reference for a research paper titled "Consolidation mFOLFOX6 chemotherapy after chemoradiotherapy improves survival in patients with locally advanced rectal cancer: final results of a multicenter phase II trial." The paper was published in the journal "Diseases of the Colon & Rectum" in 2018. The authors of the paper are Marco MR, Zhou L, Patil S, Marcet JE, Varma MG, Oommen S, et al. The study aimed to investigate the effects of consolidation chemotherapy with mFOLFOX6 after chemoradiotherapy in patients with locally advanced rectal cancer.

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Related Questions

an elderly client is admitted to the health care facility with an indirect inguinal hernia. which abnormal data should the nurse expect to find in the client assessment?

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When assessing an elderly client with an indirect inguinal hernia, the nurse should expect to find the abnormal data like lumps , swelling , pain , heaviness , redness and nausea.

An indirect inguinal hernia occurs when a portion of the intestine or other abdominal tissue protrudes through a weak spot in the inguinal canal, a passage in the lower abdomen.
1. Lump or swelling: The client may have a bulge or swelling in the groin or scrotum area. This is one of the most common signs of an inguinal hernia.
2. Pain or discomfort: The client may experience pain or discomfort in the groin area, especially when coughing, lifting heavy objects, or straining during bowel movements.
3. Pressure or heaviness: The client may feel a sense of pressure or heaviness in the groin or lower abdomen.
4. Redness or discoloration: In some cases, the skin over the hernia may appear red or discolored due to inflammation or irritation.
5. Nausea or vomiting: If the hernia becomes incarcerated or strangulated, the client may experience symptoms such as nausea, vomiting, or abdominal distension. These symptoms indicate a medical emergency and immediate intervention is needed.
It is important for the nurse to assess and monitor these abnormal data to ensure prompt intervention and appropriate care for the client. Surgical repair is typically recommended for indirect inguinal hernias, especially if they become symptomatic or complications arise. The nurse should collaborate with the healthcare team to provide comprehensive care and support to the elderly client with an indirect inguinal hernia.

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a client is brought to the psychiatric clinic by family members, who tell the admitting nurse that the client repeatedly drives while intoxicated despite their pleas for the client to stop doing so. during an interview with the nurse, which client statement most strongly supports a diagnosis of a substance use disorder?

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The client's statement indicating a pattern of repeatedly driving while intoxicated despite pleas to stop strongly supports a diagnosis of a substance use disorder.

The key indicator in this scenario is the client's repeated behavior of driving while intoxicated despite the pleas of their family members to stop. This behavior demonstrates a lack of control and disregard for the consequences associated with substance use. It suggests that the client is unable to resist the urge to drink and drive, even in the face of potential harm to themselves and others.

Substance use disorders involve a range of problematic patterns of substance use that lead to significant distress or impairment in various areas of life. The Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is widely used in psychiatric diagnoses, outlines specific criteria for diagnosing substance use disorders. These criteria include impaired control over substance use, continued use despite negative consequences, and a strong desire or inability to cut down or stop using the substance.

In this case, the client's statement provides direct evidence of impaired control over their substance use. Despite the family members' pleas to stop driving while intoxicated, the client persists in engaging in this dangerous behavior. This behavior is consistent with the diagnostic criteria for a substance use disorder, specifically highlighting the inability to control substance use despite negative consequences.

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the nurse is working a client at a public health clinic. the client says to the nurse. ""the doctor said that my cd4 count is 450. is that good?"" what is the nurse’s best response?

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The nurse's best response would be: "A CD4 count of 450 is within the normal range, indicating a good immune function."

A CD4 count refers to the number of CD4 T-cells, a type of white blood cell, in a person's bloodstream. CD4 cells play a crucial role in supporting the immune system's response to infections. The normal range for CD4 counts can vary depending on the laboratory and the specific reference values used, but a count of 450 would generally be considered within the normal range.

By informing the client that their CD4 count is within the normal range, the nurse reassures them that their immune function is functioning well. It indicates that the immune system is generally able to respond effectively to infections and maintain overall health.

However, it's important to note that CD4 counts can fluctuate over time and may be influenced by various factors, including the stage of HIV infection (if the client is living with HIV), other underlying health conditions, and recent illnesses. Therefore, it's essential for the client to continue monitoring their CD4 count and follow up with their healthcare provider for further guidance and evaluation.

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you respond to a residence for a 9-year-old female with down syndrome who is sick. when you arrive at the scene and assess the patient, you determine that she is unresponsive and has gurgling respirations. you should: chegg

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Ensure scene safety: Before approaching the patient, make sure the scene is safe for you and your team. Look out for any potential hazards or dangers. Activate the emergency response system: Call for additional help, such as EMS or paramedics, to assist you in providing the necessary care for the patient.

Open the airway: Gurgling respirations indicate that the patient's airway may be partially blocked. Gently tilt the patient's head back and lift the chin to open the airway. Be careful not to hyperextend the neck, especially if there is a suspected head or neck injury. Clear the airway: If you see any visible obstructions, such as food or objects, gently remove them from the patient's mouth using a finger sweep technique. Be cautious not to push the object further down the airway .Perform rescue breathing: Since the patient is unresponsive and not breathing adequately, you should provide rescue breaths.

If the patient remains unresponsive and doesn't have a pulse, you should initiate CPR. Begin with chest compressions by placing the heel of one hand on the center of the chest, just below the nipple line. Interlock your fingers and keep your arms straight. Push hard and fast, aiming for a rate of around 100-120 compressions per minute. After 30 compressions, provide two rescue breaths and continue with the cycles of 30 compressions and two breaths until help arrives or the patient regains consciousness. Remember, these steps are intended as a general guideline. It's crucial to follow your local protocols and receive proper training in CPR and first aid to provide the best possible care for the patient.

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13. a client has been diagnosed with major depressive episode. after treatment with fluoxetine (prozac), the client exhibits pressured speech and flight of ideas. based on this symptom change, which physician action would the nurse anticipate? 1. increase the dosage of fluoxetine.

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The physician action that the nurse would anticipate based on the symptom change of pressured speech and flight of ideas in a client with a major depressive episode after treatment with fluoxetine (Prozac) is to discontinue or decrease the dosage of fluoxetine.


The symptom change of pressured speech and flight of ideas suggests a shift in the client's mental state towards a manic or hypomanic episode. This could indicate the presence of bipolar disorder, as opposed to major depressive disorder alone. Fluoxetine is an antidepressant commonly used in the treatment of major depressive disorder, but it can trigger or exacerbate manic symptoms in individuals with bipolar disorder.

Therefore, the physician would likely discontinue or decrease the dosage of fluoxetine to address this symptom change and prevent further escalation of manic symptoms. In summary, the nurse would anticipate the physician discontinuing or decreasing the dosage of fluoxetine to address the symptom change of pressured speech and flight of ideas in a client with major depressive episode. The nurse would anticipate the physician discontinuing or decreasing the dosage of fluoxetine.

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How much fish does the American Heart Association recommend consuming per week to minimize the risk of CHD

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The American Heart Association recommends consuming fish at least twice a week to minimize the risk of coronary heart disease (CHD).

The American Heart Association (AHA) suggests incorporating fish into the diet to promote heart health and reduce the risk of coronary heart disease. Specifically, they recommend consuming fish at least two times per week.

Fish, particularly fatty fish like salmon, mackerel, sardines, and trout, are rich sources of omega-3 fatty acids. Omega-3 fatty acids have been shown to have beneficial effects on heart health, including reducing inflammation, improving blood lipid profiles, and decreasing the risk of CHD.

These fatty acids are known to have antiarrhythmic and antithrombotic properties, which can help prevent heart disease.By consuming fish at least twice a week, individuals can increase their intake of omega-3 fatty acids and potentially lower their risk of developing coronary heart disease.

It is important to note that the AHA advises against consuming fried fish or fish high in mercury, as these can have adverse effects on health. Grilling, baking, or broiling fish is recommended as healthier cooking methods. For those who are unable to consume fish, omega-3 supplements may be considered under medical guidance.

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Using knowledge of child development, the nurse interprets his behavior according to which description

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The nurse interprets the child's behavior according to their knowledge of child development. This allows them to understand and explain the child's actions based on developmental milestones and typical behaviors exhibited at different ages.

The nurse will assess the child's age and developmental milestones. For example, a toddler who is exhibiting tantrums may be going through the "terrible twos" stage, where emotional outbursts are common as they struggle with independence. The nurse will consider the child's developmental tasks. For instance, a preschooler who is having difficulty separating from their parents may be experiencing separation anxiety.

The nurse recognizes that each child is unique and may develop at their own pace. They will take into account the child's temperament, personality, and past experiences when interpreting their behavior. This helps the nurse provide accurate explanations for the child's actions and support their overall well-being. The nurse interprets the child's behavior based on their knowledge of child development, considering factors such as age, developmental stage, developmental tasks, and individual differences.

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