What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain

Answers

Answer 1

Answer:

TNF-alpha is expressed as a homotrimer that exerts its activities through binding to two types of receptors: TNFR1 and TNFR2, which are transmembrane glycoproteins characterized by having an extracellular domain with 4 cysteine-rich domains (CRD 1-4) , each with 3 cysteinecysteine disulfide bonds.

Explanation:

TNF-alpha (Tumor Necrosis Factor), which has the characteristic of being a paracrine signaling ligand, is a pleiotropic cytokine that functions as a mediator of immune regulation, the inflammatory response and apoptosis in some cell types. Receptors in this family are involved, with some exceptions, in juxtacrine signaling; that is, both the ligand and the receptor are membrane proteins with extracellular domains through which signaling is established. The cellular responses promoted by TNF are initiated by its interaction with two different types of cell receptors, the type I receptor (55 kDa) and the type II receptor (75 kDa). Both types of receptors are part of the TNF receptor family, members of which include Fas antigen (apoptosis inducer, also called Apo-1 or CD95), CD27 (T-cell activation antigen), CD30 (lymphoma marker Hodgkin) and CD40 (B-cell antigen), which share the characteristic of cysteine-rich sequences in their extracellular domains. This family of cytokines generate cellular responses that include differentiation, proliferation, activation of NFκB and cell death, promoting the aggregation of receptor monomers, that is, they have a transmembrane domain that participates in the solubilization of the receptor and a domain of intracellular death that is involved in signal transduction. The binding of TNF to TNF-R1 induces a signaling cascade through its intracellular death domain, which subsequently leads to the activation of complex I (or inflammatory) of NFkB and proceeds to the transcription of anti-apoptotic genes, pro- inflammatory diseases and apoptosis complex II (caspases).


Related Questions

*anatomy & physiology question*

if you are at 120X and the field diameter is 8.0 mm what is the field diameter if you go to 30X magnification?

Answers

Answer:

32 mm

Explanation:

The field of view is the total area visible through the microscope . The diameter of the field of view can be measured.

There is an inverse relationship between the magnification and the field diameter. As magnifications decreases, the field diameter increases by the same proportion, and as magnifications increases, the field diameter decreases by the same proportion.

The relationship between field diameter and magnification is:

magnification of A * field diameter of A = magnification of B * field diameter of B

120X * 8 mm = 30X * B

B = 120X / 30X * 8 mm

B = 32 mm = 32000 μm

The field diameter of 30X magnification is 32 mm (32000 μm)


What would make the water in a small region of the ocean more salty?
A. heavy rainfall over the region
B. melting an iceberg in the region
C. water from a river running into the region
D. evaporation of a lot of the water in the region

Answers

Answer:

Its C

Explanation:

Checked it and got it right

A cow with a mix of red hairs and white hairs has the genotype of H^R H^W . This is an example of ​

Answers

Answer:

Codominance

Explanation:

Becuase it is

How do humans affect the traits of other living things?
PLEASE HELP MY ASSIGNMENT IS DUE AT 3:30PM TODAY!

Answers

Answer:

Explanation:

well humans can play around with other animals DNA meaning is affect their protein thus their traits and example of this is genetic engineering

Genes Influence an organism's tralts by coding for:

Answers

Answer:

production of proteins

Explanation:

What can you infer about the Maastrichtian Age from its name?

Question 7 options:

A)

That is was an extremely long, complicated age.


B)

Rocks from that era were first studied near the city of Maastricht, Netherlands


C)

That is was the most strict geologic age in history.


D)

Nothing - the names of geologic ages are arbitrary.

Answers

Answer:

The B) is answer

my answer have to be atleast 20 characters long oof

The theory,of evolution states that all living things had a single common ancestor. The translation between mRNA and amino acids is the same for all living thing. Does the second statement support the theory of evolution ?

Answers

Answer: the theory of evolution states that all living things we can identify descend from the Last Universal Common Ancestor. It is not that the translation process between mRNA and amino acids is universal, but that the underlying genetic code relating DNA nucleotide triplets (codons) to amino acids is the same for almost all living things.

Explanation: The genetic code ‘tells’ mRNA which the sequence of amino acids in a protein and when to stop adding amino acids. The DNA . triplets, called codons, code for 20 amino acids and a STOP signal. The code is identical in almost all cases, but there are variation, mostly found in mitochondrial DNA. But even when these variants exist, most of the code is the same as in other living organisms. For example the codon AGG normally codes for the amino acid serine but in arthropod mitochondria it codes for lysine. These very few and minor changes tend to confirm the single ancestry of the code and how well it has been conserved through billions of replications

1. Below is a diagram of the male
reproductive system. Which structure is
represented by D?
A. scrotum
B. testes
C. prostate gland
D. epididymis

Answers

Answer:

A:scrotum

Explanation:

its part of the male reproductive system. I looked it up.

What is the independent variable?

What is the dependent variable?

Answers

Answer:

the independent is the age of the tree and the dependent is the diameter

Explanation:

the diamter of the tree is based off of the age as we can see that it gets bigger the older the tree is

Answer: Independent variable: age of the tree (years), Dependent variable: tree diameter (mm)

The diameter of the tree is dependent on what age the tree is. As the tree gets older, the diameter increases. The dependent variable depends/relies on the value(s) of the independent variable.

which of the following are part of the central nervous system?​

Answers

Answer:

The central nervous system is made up of the brain and spinal cord

Explanation:

ion if that's the answer you were looking for but here go.

What is the medical term for the process or procedure that destroys or inhibits disease-causing microorganisms to prevent infection:

Answers

Answer: Sterilization.

Explanation:

Sterilization is the process that kills, or deactivates all forms of life so then a product is considered free of viable microorganisms. This process must be designed, validated and carried out to ensure that it is capable of eliminating the microbial load of the product.

Since sterility cannot be demonstrated without causing the complete destruction of the products, sterility is considered when the probability of a product being contaminated is acceptably remote. A critical product is considered sterile when the probability of a microorganism being present in an active or latent form is equal to or less than 1 in 1,000,000 (sterility safety factor 10^-6).

Agents that kill microorganisms are called microbicides or more commonly called "germicides". If the agent kills bacteria, it is called a bactericide. And if it kills fungi, then it is called a fungicide. It is important to consider than after an exposure of the sterilized object to the air or its surroundings, it will have become contaminated again with microorganisms.

Examples of sterilization include physical methods and chemical methods. Physical methods include:

Wet heat (in steam autoclave) Dry heat (in sterilization oven) Radiation (gamma radiatio, electron beam, X-ray, ultraviolet, microwave, white light)

Chemical methods include a variety of chemicals in liquid and vapor form, for example:

Hydrogen peroxideChlorine dioxideOzone gasesEthylene oxidePropylene oxidePeracetic acid

How will weathering and erosion most likely affect the Grand Tetons over the next 9 million years?
A.
The Grand Tetons will stay exactly the same as they are today.
B.
The Grand Tetons will become steeper and more rugged.
C.
The Grand Tetons will become less steep and more rounded.
D.
The Grand Tetons will become much taller than they are today.

Answers

Answer:

the correct answer to the question in c

Answer: C)The Grand Tetons will become less steep and more rounded.

Explanation:

How will weathering and erosion most likely affect the Grand Tetons over the next 9 million years? C)The Grand Tetons will become less steep and more rounded.

Only answer if you know the answer

Answers

Answer:

B. A helicase enzyme unwinds the DNA molecule, then corresponding nucleotides are added to the separated original strand forming two separate semiconservative molecules

Explanation:

DNA Replication is an important phenomenon as far as cell division is concerned. It is the process whereby a DNA molecule doubles its content or forms two DNA molecules from one.

In the semi-conservative model of DNA replication, an enzyme called DNA helicase unwinds the double stranded DNA molecule into two single strands. The single strands are then used as template for DNA polymerase to synthesize another molecule of DNA. Hence, two separate DNA molecules comprising of one old strand and one new strand.

If the sodium/potassium ion pump were to stop functioning, what would eventually happen to the concentration gradients of sodium and potassium ions across the membrane

Answers

Answer:

The correct answer would be - concentration gradient will reach to equilibrium.

Explanation:

If the Na+/K= ion pump stops working which is to pump the sodium and potassium ion across the cell membrane. The movement takes place in 3:2 ratio with the help of ATP.

Eventually, the concentration gradients of sodium and potassium would be equal and found equilibrium across the membrane. This equilibrium would be reached due to passive transport that occurs in either direction across the membrane.

The F1 mother of these progeny (F2) resulted from a cross between two flies from true breeding lines (P generation). What are the genotypes of these two lines

Answers

The question is incomplete. The complete question is :

In fruit flies, the recessive pr and cn mutations cause brown and bright-red eyes, respectively (wild-type flies have brick-red eyes). The double mutant pr cn combination has orange eyes. A female who has wild-type eyes is crossed to an orange-eyed male. Their progeny have the following distribution of eye colors:

wild-type8

brown241

bright-red239

orange12

500

The F1 mother of these progeny (F2) resulted from a cross between two flies from true breeding lines (P generation). What are the genotypes of these two lines ?

Answer:

prprcn+cn+ and pr+pr+cncn

Explanation:

Progeny is the offspring or descendants of any animal, plant, human or a species.

In the context, it is given that the cn mutation and recessive pr in the fruit flies makes brown and bright red color eyes. And the double mutant of pr and cn combination makes orange eyes. An oragne eye males is crossed with a female having a wild type eyes. Now for this, the F1 mother of the progeny F2 which results from the cross of two flies, the genotypes is " prprcn+cn+ and pr+pr+cncn. "

Which activity can be accomplished using the genetic code?
O A polypeptide can be made into mRNA
. DNA can be made into mRNA
O RNA can be copied before mitosis.
O mRNA can be made into tRNA

Answers

Answer:

DNA can be made into mRNA

Explanation:

You have adopted a gray mouse, which you know is a wild type phenotype. When crossed with a white mouse, your gray mouse has a first litter of 3 gray mice and 2 white mice. In the second litter, you observe 3 gray mice and 4 white mice. What is the probable genotype of your gray mouse

Answers

Assuming the white phenotype is recessive. white: gg
I think the gray mouse is Gg because the offspring were pretty equally distributed in terms of color. See the punnet square below.
g g
G| Gg Gg
g| gg gg

If the Gray phenotype is recessive, then gray: ww but only if white is Ww because its about 50% chance for both.

pls answer correctly

Answers

Answer:

2nd answer bubble. or the letter B

a sound wave traveling through dry air has a frequency of 16 Hz, a wavelength of 22 m, and a speed of 350 m/s. When the sound wave passes through clouds of nitrous oxide, it’s wavelength changes to 16 m, while it’s frequently remains the same. What is it’s new speed?

Answers

please urgent please help

Choose all the answers that apply.
Eukaryotes _____.

are always multicellular
are always unicellular
may have evolved from prokaryotes
have membrane-bound organelles
have a true nucleus
are more primitive than prokaryotes

Answers

Answer:

3 answers

Explanation:

may have evolved from prokaryotes

have membrane bound organelles

have a true nucleus

Hope it helps.....

Which description represents a medium?
a - energy that moves with a wave
b-midway point through a wave
c- a wave that can travel through a vacuum
d- material through which waves can travel​

Answers

The answer is b
Midway point through a wave

Why is politics important for stopping climate change?
1. Because politicians are responsible for more greenhouse gas emissions than regular people.
2. Because climate change isn't really a scientific issue, only a political one.
3. It isn't, private companies are already doing everything necessary to combat climate change.
4. Because it's unlikely action will be taken fast enough without the government passing laws to reduce our impact on the
climate.

Answers

Answer: it’s number 4

An organism is currently using light energy to make food. Based on what you have learned, this organism will be best classified as

Answers

Answer:

This organism is best classified as an autotroph.

Explanation:

Autotrophs can make their own food.

What is RNA primase's job?
-removing a few bases for DNA polymerase
-add a few bases for DNA polymerase
-removing a few bases for helicase

Answers

Answer:

The correct answer is - add a few bases for DNA polymerase

Explanation:

A short extended nucleic acid composed of ssRNA molecule. This is a molecule that synthesize a primer initialy and later again lay down a primer after the opening of replication fork by DNA helicase.

It sysntheisze before and after the helicase and follow the helicase in order to prepare for the replication process. Thus, adding a few bases for DNA polymerase is main job of RNA primase.

Volcanoes can form near coastal regions where an oceanic plate [blank] below a continental plate

Answers

Answer:

Subducts

Explanation:

According to Merriam Webster and TheFreeDictionary, the definition of subduct is "A geologic process in which one edge of one crustal plate is forced below the edge of another." Since this sentence indicates that an oceanic plate sinks under the continental plate, therefore I believe the fill-in-the-blank word would be 'subducts' or a similar word.

1 point
7. In the wild, rabbits breed very quickly producing many offspring in a
short period of time. Which of the following is most likely the reason why
rabbits have adapted the ability to breed quickly? *
There are many diseases that wipe out entire rabbit populations
O They have limited habitats that they live in
There is limited food in most habitats
O They have many predators and short life spans

Answers

Answer:

they have short life spans and many predators.. hope this works

Lab: Natural Selection answer in the link pls 50 points and

Answers

We cannot see the image, tell me in the comments what you want me to answer maybe i can help you.

Daphne identifies the entire sequence of nucleotides in a gene. Based on this information and the genetic code, she predicts the sequence of amino acids in the protein that the gene codes for. What is the MOST LIKELY reason that Daphne’s prediction would be incorrect?

The gene codes for a carbohydrate, and not a protein.
A mutation changes the genetic code that the cell uses.
The cell removes introns from pre-mRNA.
The cell removes introns from DNA.

Answers

Answer:

The cell removes introns from pre-MRNA

Explanation:

which statement describes what happens to rocky shorelines that absorb energy from ocean waves?

Answers

Answer:

Solid rock break apart

Explanation:

What's the definition of absoulute dating

Answers

Absolute dating is the process of determining an age on a specified time scale in archaeology and geology. Some scientists prefer the terms chronometric or calendar dating, as use of the word "absolute" implies an unwarranted certainty and precision. Absolute dating provides a numerical age or range in contrast with relative dating which places events in order without any measure of the age between events. In archeology, absolute dating is usually based on the physical, chemical, and life properties of the materials of artifacts, buildings, or other items that have been modified by humans and by historical associations with materials with known dates. Techniques include tree rings in timbers, radiocarbon dating of wood or bones, and trapped charge dating methods such as thermoluminescence dating of glazed ceramics. Coins found in excavations may have their production date written on them, or their may be written records describing the coin and when it was used, allowing the site to be associated with a particular calendar year.

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The wealthy plantation owners of Saint-Domingue [Haiti], therefore, have everything to fear from the influence of our revolution on the current actions of their slaves. These principles overturn the system on which rests their fortunes. No one should be surprised, therefore, that these plantation owners have become the most ardent enemies of these principles. Yet the moment has arrived to change the social system of the colonies, to reintegrate it into humankind. It is in this greater action that the salvation of all parties, justice, and glory will be found.The free men of color demand justice, and they should be granted the same rights of citizenship as other Frenchmen. The colonists should no longer refuse them. The artisan slaves should also be called to freedom on the condition that each slave pays a one-time tax for freedom. 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