A researcher wanted to create a loss of function mutation for studying Type I Diabetes in a model animal. What mutation would mimic Type I diabetes?
a) Inhibition of sugar absorption in the small intestine
b) Inhibition of pancreatic beta-cells
c) Up regulation of insulin receptors on the pancreas
d) Down regulation of GLUT4 transporters in muscles

Answers

Answer 1

Answer:

The correct answer is: b) Inhibition of pancreatic beta-cells.

Explanation:

Type 1 Diabetes is a form of Diabetes Mellitus, a condition characterized by chronic hyperglycemia (high blood sugar levels) that can compromise many organs and even cause death if not treated properly.

The most common form of Diabetes Mellitus is Type 2 Diabetes, in which the pancreas produces insulin but cannot reach the target organs because of a pathologic state called Insulin Resistance.

Type 1 Diabetes, instead, is present in patients that cannot produce insulin on their own. Insulin is the most important hormone in the regulation of blood sugar - it is secreted by the pancreatic beta-cells when glycemia rises (which is normal after eating) and it is key in allowing glucose to reach the tissues where it's needed for energy requirements. Type 1 Diabetes is usually diagnosed in young, even pediatric, patients - the pancreatic beta-cells in these individuals are destroyed and unable to function (the reason for this is not clear in all cases), so they have to be administered with exogenous insulin to survive.

For the model animal to better represent Type 1 Diabetes, the mutation would have to inhibit pancreatic beta-cells.


Related Questions

a. Why was it important in this case to identify Salmonella Typhi in the feces of the restaurant worker?​

Answers

Answer:

Some other types of Salmonella cause typhoid fever or ... Most people with Salmonella infection have diarrhea, fever, and ..

Explanation:

Add as brainlist

The bacterium Methylophilus methylotrophus can use methanol and ammonia for protein synthesis. The glutamate dehydrogenase gene from E. coli was introduced into M. methylotrophus using recombinant DNA techniques. Under high ammonia conditions, the introduction of the glutamate dehydrogenase gene into M. methylotrophus resulted in an increase in protein yield. Select the statements that are reasonable explanations for the increased protein yield in the modified M. methylotrophus. Glutamate dehydrogenase catalyzes the formation of glutamate and glutamine in a two-step process. Both glutamate and glutamine play a key role in amino acid synthesis, thus an increase in levels of glutamate and glutamine increase protein synthesis. Glutamate dehydrogenase has a low affinity for NH^+_4, and can only catalyze the formation of glutamate from alpha-ketoglutarate and NH^+_4, when the concentration of NH^+_4 is high. Glutamate dehydrogenase has a high affinity for NH^+_4, thus the rate of glutamate synthesis increases exponentially under high ammonia conditions. Glutamate is the amino group donor for most transamination reactions involving amino acids, thus an increase in glutamate concentration increases protein synthesis.

Answers

Answer:

- Glutamate dehydrogenase has a low affinity for NH+4, and can only catalyze the formation of glutamate from alpha-ketoglutarate and NH+4, when the concentration of NH+4 is high.  

- Glutamate is the amino group donor for most transamination reactions involving amino acids, thus an increase in glutamate concentration increases protein synthesis.

Explanation:

Glutamate dehydrogenase (GLDH) is an enzyme found in prokaryotic and eukaryotic cells, which is known to catalyze the reversible oxidative deamination of glutamate (Glu) to alpha-ketoglutarate and ammonia at the same time the oxidation of NADH to NAD. In bacteria, this enzyme (GLDH) is efficient only at high concentrations of the ammonium cation (NH4+), because it has a low affinity for NH4+. Moreover, transamination is a pathway that involves the transfer of an amino group from one amino acid to a ketoacid in order to form new amino acids (this reaction is responsible for the deamination of most amino acids). Glu is the donor of amino groups in most of the reactions catalyzed by enzymes involved in the transamination between an amino acid and an alpha-keto acid. In consequence, in presence of GLDH, a high concentration of Glu will increase the production of new amino acids and therefore also protein synthesis.

When curare, a neuromuscular poison, is dropped onto an isolated muscle-nerve preparation in a laboratory, the muscle does not contract when the nerve is stimulated, even though neurotransmitter is released from the nerve cell. Why does this happen

Answers

Answer:

Explanation:

Whenever the nerve terminal's action potential depolarizes, calcium enters the cell through the channels. Calcium allows acetylcholine (ACh) to be released more easily.  These ACh molecules subsequently circulate into the synaptic cleft and attach to the motor end-plate of the nicotinic cholinergic receptors. Acetylcholine molecules connect to nicotine ion-channel receptors present on cell membrane the of muscle cells, enabling the ion channels to open. Calcium ions then enter the muscle cell, kicking off a series of events that eventually result in muscular contraction.

Curare is a kind of neuromuscular relaxant blocker that is non-depolarized in nature. Nondepolarizing muscle relaxants work as competitive agonists, binding to ACh receptors but failing to activate ion channels. As a result, they inhibit ACh from bonding, preventing the development of endplate potentials and inducing muscle paralysis.

Which food has the greatest amount of polyunsaturated fat?

Answers

there are multiple foods that do, some examples are:
walnuts
sunflower seeds
fish
There are multiple foods

How many kingdoms are there in the domain Bacteria?
O A2
OB. 1
O c. 3
O D. 4

Answers

Answer:

There is 1 kingdom in the domain Bacteria

Explanation:

Answer:

B. 1

Explanation:

one Kingdom

Domain Bacteria has one Kingdom: Kingdom Eubacteria.

How many kingdoms are there in the domain bacteria? | Study ...https://study.com › academy › answer › how-many-kingd...

In a Nitrogen metabolism study, the following data were obtained over the test period:

Nitrogen consumed 175 grams
Total Fecal N 35 grams
Metabolic Fecal N 10 grams
Total Urinary N 80 grams
Endogenous Urinary N 10 grams

Calculate:
a. Apparent Nitrogen digestibility (%)
b. True Nitrogen digestibility (%)
c. Nitrogen Balance (g)
d. Apparent Nitrogen Retention (%)

Answers

Answer:

a. 80%

b. 86%

c. 60 g

d. 34.29%

Explanation:

From the given information:

The apparent nitrogen digestibility (AD) is the ratio of the difference between the consumed nitrogen and fecal nitrogen to the consumed nitrogen.

Mathematically:

[tex]AD = \dfrac{consumed \ nitrogen - fecal \ nitrogen }{consumed \ nitrogen }[/tex]

[tex]AD = \dfrac{175 -35 }{175}[/tex]

AD = 0.8

To percentage, the apparent Nitrogen digestibility = 80%

b. True Nitrogen digestibility is calculated by the formula:

[tex]=\dfrac{consumed \ nitrogen - (fecal \ nitrogen -metabolic \ fecal)}{consumed \ nitrogen}[/tex]

[tex]= \dfrac{175 -(35-10)}{175}[/tex]

[tex]= \dfrac{175 -25}{175}[/tex]

= 0.86

= 86%

c. Nitrogen Balance = consumed Nitrogen - Fecal nitrogen - total uninary

Nitrogen Balance = (175 - 35 - 80) grams

Nitrogen Balance = 60 g

d. Apparent Nitrogen Retention (ANR) is computed as follows:

[tex]ANR = \dfrac{(consumed \ nitrogen-fecal\ nitrogen - total \ uninary )}{nitrogen \consumed }\times 100\%[/tex]

[tex]ANR = \dfrac{(175-35- 80 )}{175 }\times 100\%[/tex]

[tex]ANR = \dfrac{(60 )}{175 }\times 100\%[/tex]

ANR = 34.29%

number of cell that undergo meiotic division to produce a 216 gametes in gymnosperms is​

Answers

meiotic devision this is the answer it might help you

Which of the following techniques employs a probe consisting of a labeled, single-stranded DNA of known sequence that can find and bind to a complementary sequence present in a large sample of different DNA sequences?

a. DNA hybridization
b. RFLP
c. PCR
d. DNA sequencing

Answers

Answer:

Explanation:

PCR

Z 00m 336"083"2553 (wZE2XQ)​

Answers

Bjsjhehsbdbdhhdvhdvxbdgvdbxhsbd

What is a plant nucleus

Answers

Answer:

All plant cells contain a nucleus, a structure that stores DNA and acts as a cell's command center. It is surrounded by the nuclear envelope and is filled with nucleoplasm. ... DNA is copied during DNA replication for new cells, as well as copied to RNA to make proteins in the nucleus.

a phlebotomy technician has collected a neonatal screening card. which of the following actions should the technician take to properly dry the blood stop collection card?

Answers

Answer:

place the card on a flat dry surface

Prepare a collage of tools and equipment used in production of any one agricultural crop, from seed or planting through packaging of the produce

Answers

Answer:

i think

Explanation:

Scientists have been studying the size of three populations in a river in Ireland. In this ecosystem, pike (a type of big fish), and perch eat snails. The data showed that all three populations were stable. Then the snail population increased suddenly. What will likely happen to the size of the perch population as a result? The size of the perch population will...

Options:

A. Stay the same. The size of it's consumer population did not change, so the number of deaths in the perch population did not change. There will be the same number of births and deaths in the perch population.

B. Decrease. The larger snail population will take more energy storage molecules from the ecosystem, leaving fewer available for the perch population. This will lead to more deaths than births in the perch population.

C. Increase. The larger snail population will provide more energy storage molecules for the perch population, so they will reproduce more. This will lead to more births than deaths in the perch population.

D. Increase. An increase in any population within an ecosystem will lead to an increase in the sizes of all other populations in the ecosystem.

Answers

Answer:

C. Increase. The larger snail population will provide more energy storage molecules for the perch population, so they will reproduce more. This will lead to more births than deaths in the perch population.

Explanation:

Which of the following findings would lead you to determine that an infant's airway is open

Answers

Answer:

blowing air into his/her mouth and checking for an increase in the thoracic region........I GUESS

Consider the factors that affect muscular strength. Read each scenario and then identify each label into the appropriate category based on whether each would result in a stronger or weaker muscle contraction.

a. Potassium accumulate in the sarcoplasm
b. Increase in muscle belly circumference
c. Lesser proportion of motor neurons to muscle fibres
d. Begin contractions with muscle already 50% contraction
e. Lower sarcoplasm pH
f. Increased stimulus frequency.
g. Circular arrangement of muscle fascicles
h. increased requirement.

Answers

Answer:

1. Weaker contraction:

a. Potassium accumulate in the sarcoplasm

d. Begin contractions with muscle already 50% contraction

e. Lower sarcoplasm pH

g. Circular arrangement of muscle fascicles

2. Stronger Contraction

b. Increase in muscle belly circumference

c. Lesser proportion of motor neurons to muscle fibres

f. Increased stimulus frequency.

h. increased requirement.

Explanation:

Sarcoplasm refers to the cytoplasm of muscle cells which contains ATP, enzymes, and a variety of ions, including potassium (K+). The negative potential required during muscle activity is produced from the disequilibrium of ionic concentrations (mostly Na+ and K+) across the membrane, which is generated through Na+/K+ ATPase pumps. During contraction, a muscle shortens, and thus its circumference increases. The generation of lactic acid is known to lower pH in the sarcoplasm and thus hinder the force and power development of the muscle fibers. Muscle fascicles can be arranged in concentric rings, it is a common pattern in sphincter muscles that modulate the opening and closing of orifices (which have weak contractions). A motor unit refers to a single efferent neuron and all of the muscle fibers it modulates. Each individual muscle fiber is innervated by one motor neuron, whereas a single motor neuron can innervate many muscle fibers. Finally, higher intensity/frequency are known to induce stronger muscular contractions, but also produce a stronger decline in force and cause more rapid muscle fatigue.

Without replication, organisms could not successfully


move.

grow and reproduce.

feed.

make proteins.

Answers

Answer: grow and reproduce

Explanation:

•. otal genomic structure of an organism inherited from parents is known as -
a) Gene
b) Allele
c) Phenotype
d) Genotype​

Answers

I think the answer is a sorry if I get it wrong

Explain why you would recommend the nguni cattle meat to consumers in your locality.​

Answers

Answer:

Below

Explanation:

All different combinations were catalogued in the beginning of the century by a South African herdmaster. This work inspired the Nguni Cattle Register, a compilation of terms to describe in full a Nguni cow or bull. The cattle are medium-sized, with bulls weighing between 500 and 600 kg,[3] while cows weigh between 300 and 400 kg.

Which of the following is true
about true-breeding plants if they are allowed to self-pollinate?

A. They never have offspring with the same traits as the parent plant.

B. They have offspring with traits that are identical to the parent plant with one or two differences.

C. They always have offspring with traits identical to the parent plant.

Answers

Answer:

b

Explanation:

some are the same while others are different (traits)

Answer true or false.

1._____The central nervous system consists of the brain, spinal cord, and nerves.

2._____The autonomic system is part of the nervous system that controls involuntary
actions in the body.

3._____A fish has a more highly developed brain than an ape.

4.______The spinal cord is part of the respiratory system.

5._____The three main parts of the brain in vertebrates are the cerebrum, the
cerebellum, and the brain stem.​

Answers

Answer:

1. False

2. -----

3. False

4. False

5. True

I'm not sure of the 2nd question

Hope it helps:)

Answers:
1. True
2. True
3. False
4. False
5. True

Explanation:
1. This is true.
2. This is true.
3. Apes are highly intelligent creatures will have more brain development than fish.
4. The spinal cord is a part of the nervous system, which is responsible for signaling things. Whereas the respiratory system is responsible for supplying the body with oxygen.
5. This is true.

Select the correct answer.
How does the high specific heat of water help maintain the temperature of earth?
A By heating and cooling more slowly than land or air
B. By heating and cooling faster than land or air
с.
By heating faster but cooling more slowly than land or air

Answers

i’m pretty sure it is B

The high specific heat of water help maintain the temperature of the Earth by heating and cooling more slowly than land or air. Thus, the correct option is A.

What is the specific heat of water?

The specific heat of an object is the amount of heat which is required to increase or raise the temperature of unit mass of that particular substance through one degree celsius. Specific heat is represented by the symbol 'c'. Its unit in SI system is Joule /(kg °C) and in CGS is cal / (gm °C).

The high specific heat of water helps in regulating the rate at which air changes its temperature, which is why the temperature of the planet change between different seasons is gradual rather than sudden, especially the geographical locations near the ocean.

Therefore, the correct option is A.

Learn more about Specific heat here:

https://brainly.com/question/11297584

#SPJ2

14. What do the embryos of different vertebrate species have in common?​

Answers

Answer:

Similarities in embryos are evidence of common ancestry. All vertebrate embryos, for example, have gill slits and tails. Most vertebrates, except for fish, lose their gill slits by adulthood.

Explanation:

itz from gologolo lol I hope it helps uh

keep smiling #smilies

A cell has twice as many mitochondria as a typical cell. It also has a large amount of rough ER. What functions
might that cell have?

Answers

Answer:

below

Explanation:

definition of human rights

Answers

Answer: a right that is believed to belong justifiably to every person.

Explanation:

Answer:

Human rights are standards that allow all people to live with dignity, freedom, equality, justice, and peace. Every person has these rights simply because they are human beings.

Explanation:

Human rights are rights inherent to all human beings, regardless of race, sex, nationality, ethnicity, language, religion, or any other status. Human rights include the right to life and liberty, freedom from slavery and torture, freedom of opinion and expression, the right to work and education, and many more.

Phân tích các yếu tố cho thấy ĐẤT là môi trường đa dạng nhất về các loại sinh vật?

Answers

.... what you wrote isn’t a question.... you wrote a statement.....

Here is what you wrote translated to English

Analysis of factors shows that SOIL is the most diverse environment in terms of organisms?

Answer:

I don't no answer sorry

Explanation:

follow

How many kinds of mosquito are common in Nepal l​

Answers

there are 130 kinds of mosquito are common in Nepal l

What is the role of RNA?

Answers

Answer:

It is the 1st one ○ to provide the original blueprint for protein production

Explanation:

RNA polymerase (green) synthesizes RNA by following a strand of DNA. RNA polymerase is an enzyme that is responsible for copying a DNA sequence into an RNA sequence, duyring the process of transcription.

Assignment: 04.02 The Biosphere
In this lesson, you took a tour of three of our unique aquatic biomes. In this assessment, you will take a virtual field trip to any aquatic ecosystem of your choice and learn about the biotic and abiotic factors that shape it.

A virtual field trip is a Web search of a location you are unable to visit in person. For this virtual trip, pick any sea, lake, bay, or river in the world and research the biotic and abiotic factors that make it unique. Include the following features in your virtual field trip research:

1. the location of your body of water
2. a description of the geography surrounding your body of water
3. the effects of sunlight on the aquatic life inhabiting your body of water
4. the depths and salinity of your body of water and how this shapes the types of aquatic life present
5. the effects of seasonal changes to water temperatures and aquatic life in your body of water
6. predictions or current research on the effects of climate change to your body of water

Once, you’ve gathered your research, share your virtual field trip with us. Include pictures of your aquatic ecosystem and the life within it in your presentation, but make sure to cite the sources of your pictures and research. Please review the student example and rubric for this virtual field trip before continuing.

You may share your field trip in any creative format you would like. Here are a few suggestions:
- video or media presentation
- slide show
- Web page
- illustration that includes research notes If you need would like an assessment outline

Answers

Like terrestrial biomes, aquatic biomes are influenced by a series of abiotic factors. The aquatic medium—water— has different physical and chemical properties than air, however. Even if the water in a pond or other body of water is perfectly clear (there are no suspended particles), water, on its own, absorbs light. As one descends into a deep body of water, there will eventually be a depth which the sunlight cannot reach. While there are some abiotic and biotic factors in a terrestrial ecosystem that might obscure light (like fog, dust, or insect swarms), usually these are not permanent features of the environment. The importance of light in aquatic biomes is central to the communities of organisms found in both freshwater and marine ecosystems. In freshwater systems, stratification due to differences in density is perhaps the most critical abiotic factor and is related to the energy aspects of light. The thermal properties of water (rates of heating and cooling and the ability to store much larger amounts of energy than the air) are significant to the function of marine systems and have major impacts on global climate and weather patterns. Marine systems are also influenced by large-scale physical water movements, such as currents; these are less important in most freshwater lakes.

The ocean is categorized by several areas or zones (Figure 44.21 (Links to an external site.)). All of the ocean’s open water is referred to as the pelagic realm (or zone). The benthic realm (or zone) extends along the ocean bottom from the shoreline to the deepest parts of the ocean floor. Within the pelagic realm is the photic zone, which is the portion of the ocean that light can penetrate (approximately 200 m or 650 ft). At depths greater than 200 m, light cannot penetrate; thus, this is referred to as the aphotic zone. The majority of the ocean is aphotic and lacks sufficient light for photosynthesis.

Which characteristic is unique to vertebrates?

A) they all have a well-defined skeleton

B) they have no defined organ systems

C) they have bilateral symmetry

D) they have an exoskeleton

Answers

Answer: They have well-defined skeleton.

Explanation:

This is because the vertebrates are uniquely characterised by the presence of the bones.

Answer:

Answer is A)They have a well-defined skeleton

Explanation:

most reasonable answer

What is seed technology?why is still considered as one of the major subject in agriculture?​

Answers

Seed technology is the science dealing with the methods of improving physical and genetical characteristics of seed. It involves such activities as variety development, evolution and release of varieties, seed production, seed processing, seed certification and storage. Thus seed technology is interdisciplinary science which includes broad range of subjects. It also includes seed quality control, seed marketing, seed distribution and research on above aspects of seed.
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Three forces are pulling on the same object such that the system is in equilibrium. Their magnitudes are F1 = 2.83 N.F= 3.35 N. and F3 = 3.64 N, and they make angles of 0, = 45.0, 02 = -63.43 and 03 =164.05 with respect to the x-axis, respectively.Required:a. What is the x-component of the force vector F1?b. What is the y-component of the force vector F1? please help me please help me please help me please help me please help me please help me please What impact does sitting have on the brain? What are your classes like? What are your teachers like? Select three classes and write a sentence describing each of them (for a total of three sentences). Then select two teachers and write a sentence describing each of them (for a total of two sentences). You should have a total of five complete sentences in Spanish. Jaheem has a goal running a total of 125 miles this month. Each day that he ran, he ran 7 miles. Which expression could Jaheem use to determine how many miles he has left to run after running for d days?x a.125 7dx b.7d + 125x c. fraction numerator 125 over denominator 7 d end fractionx d.7d Choose the Athat seems to be congruent to the given one.R.FDBAEGFAOEGDo CGDBGC who are the frontliners?? The reason that the mail bed appears pink is the presence of a larger number of melanocytes in the underlying dermis The problem has been started for you.What is the quotient?8686.686.ModifyingAbove 6 with bar87 A chewing gum consists of 30% corn syrup and 40% sugar. The rest was made up by gum Arabic. Find the weight of the Gum Arabic in a 25gm piece of the chewing gum. Max points pls just bloody answer it If a +b+c=9 and a square +b square +square =1 then ab+bc+ca Congruent angle pairs : find value of x and the value of y What is Mathematics? Mt hc sinh lm th nghim sng dng trn dy cao su di L vi hai u A v B c nh . Xt im M trn dy sao cho khi si dy dui thng th M cch B mt khong a < L/2 . Khi tn s sng l f = f1 = 60 Hz th trn dy c sng dng v lc ny M l mt im bng . Tip tc tng dn tn s th ln tip theo c sng dng ng vi f = f2=72 Hz v lc ny M khng phi l im bng cng khng phi im nt . Thay i tn s trong phm vi t 73 Hz n 180 Hz , ngi ta nhn thy vi f = fo th trn dy c sng dng v lc ny M l im nt . Lc , tnh t B ( khng tnh nt ti B ) th M c th l nt th ? what will most likely happen if a population is large and no migration, mutation, or environmental change occurs?1. natural selection will increase2. nonrandom mating will start to occur3. the rate of evolution will increase4. gene frequencies will remain constant Which word BEST describes 3x, 5y, and z in the expression 3x 5y + z?A) termsB) productsC) variablesD) coefficients You are the RN starting your shift on a pediatric unit. You are taking care of a 7-month-old infant who has been alert and behaving in an age-appropriate manner on the previous shift. When you perform your first assessment, his parents tell you that in the last hour, he has become sleepier and did not cry when the lab technician drew blood a few minutes ago. Your response is toA. encourage the parents to keep the room quiet to allow him to sleep.B. document it and plan to recheck him in an hour.C. tell his parents to make him wake up because it is not time for him to go to bed.D. realize that lethargy in an infant is always an ominous neurological sign and immediately assess him. if LMNO is a rectangle, and MO=54, what is the length of line NP?answers a.) 34b.) 22c.) 18d.) 108e.) 27f.) cannot be determined pls solve quickly !! it is given 5 and h + 1 are the roots of the quadratic equation x2 + (k - 1)x-5 = 0, where h and k are constants. Find the values of h and k.