APC is a tumor suppressor and acts in the Wnt signaling pathway to prevent the TCF complex from turning on Wnt-responsive genes. Mice that lack the gene encoding TCF4 do not have the ability to maintain the pool of proliferating gut stem cells needed to renew the gut lining. What do you predict will happen in mice that lack the APC gene

Answers

Answer 1

Answer:

As APC is indicated as a tumor suppressor, lack of APC would lead to tumor development in the mutated mice.

Explanation:

The wnt signaling pathway plays an important role in controlling stem cell proliferation. Stem cells are present in the gut and other locations where they are required to be replenished after short intervals. In the gut, the gut epithelial is exposed to a very tough environment i.e. digestive acids. Thus it is replenished where the new stem cells originate from underlying stem cells.

Axin binding is the major component of this process. However, the unaffected axin leads to binding with a component termed TCF. TCF4 genes include cell cycle factors (such as myc) that encourage cell regeneration.

When the ligand is absent and APC is present, the axin bound with APC to form a team that directs and controls the cell regeneration.

Thus, if APC is not expressed in a cell, beta-catenin in the axin is available to bind to TCF inducing wnt response element genes that stimulate cell proliferation.

The result in tissue level is an enhanced rate of cell growth which leads to tumor.  


Related Questions


What is an genotype

Answers

Answer:

Genotype refers to genetic makeup of an organism.

The genetic constitution of a cell, an individual, or an organism. The genotype is distinct from the expressed features, or phenotype, of the cell, individual, or organism.

hope it helps

You are a reporter working in 2001 who's just been assigned a story on how ciprofloxacin may save the lives of Senate staff exposed to anthrax. Complete a short paragraph that links how DNADNA is replicated to defense against this act of bioterrorism.

Match the terms in the left column to the appropriate blanks in the sentences on the right. Terms can be used once, more than once, or not at all.

separate tensed
ligase unwinding
relaxed enhances
inhibits uniting
gyrase join
helicase

Bacterial DNA is a double-stranded helix that has to ___________ its strands during replication. The _______ of DNA strands at the replication fork creates twists farther down the helix that need to be ______ by DNA _______. Ciprofloxacin ______ this enzyme to block DNA synthesis and stop the deadly bacteria from growing.

Answers

Answer:

Bacterial DNA is a double-stranded helix that has to separate its strands during replication. The unwinding of DNA strands at the replication fork creates twists farther down the helix that need to be relaxed by DNA gyrase. Ciprofloxacin inhibits this enzyme to block DNA synthesis and stop the deadly bacteria from growing.

Explanation:

DNA which stands for deoxyribonucleic acid is the molecules that stores genetic information in most living organisms. For successive reproduction to take place as well as growth to occurs in organisms, the genetic information stored in the DNA must be copied into new cells. This is achieved through the process of DNA replication.

DNA is a double-stranded molecule that is helical in shape. For replication to occur, the double strands has to be separated so that the information stored within can be accessed and then copied. DNA helicases are enzymes which are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied. The unwinding of DNA strands at the replication fork creates twists farther down the helix that need to be relaxed otherwise, the DNA strands will break. The enzyme responsible for relaxation these twists is known as DNA gyrase. Thus, any drug like Ciprofloxacin than inhibits DNA gyrase will block the DNA replication process in bacteria thereby stopping the growth of the bacteria.

Bacterial DNA is a double-stranded helix that has to separate its strands

during replication. The unwinding of DNA strands at the replication fork

creates twists farther down the helix that need to be relaxed by DNA gyrase.

Ciprofloxacin inhibits this enzyme to block DNA synthesis and stop the

deadly bacteria from growing.

The antibiotic referred to as Ciprofloxacin acts on the DNA of the bacteria

and it does this by inhibiting the enzyme that is required for DNA

synthesis. This stops replication and the anthrax bacteria from growing and

forming new organisms.

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13) On Earth, water vapor occurs in the state of matter. a.) Solid Ob.) Liquid C.) Gas d.) Plasma

Answers

Answer:

Gas

Explanation:

Because when we heat water water vapour will come in the gas form

Answer:

The answer is gas

Explanation:

Sorry I don't really know how to explain, when water vapor occurs, the water rise up to the sky in the form of gas.

Hope this will help❤️

necesito ayuda con esta sopa de letras por favor​

Answers

Answer:

Do you have a list?

Explanation:

5
5. What happens to energy when chemical bonds are formed? You w

Answers

Answer:

The total energy input or output of a reaction equals the energy released in forming new bonds minus the energy used in breaking the original bonds. If it takes more energy to break the original bonds than is released when the new bonds are formed, then the net energy of the reaction is negative

Explanation:

A woman with type A blood is claiming that a man with type AB blood is the father of her child who is type B.
Can this man be the father of her child?
A No
B. Cannot be determined
C Yes


HELLPPP

Answers

Answer:

I think C

Explanation:

Not 100% $ure tho

Which of the following is not a characteristic of enzymes?
Each is used to break down substances.
Each has a specific substrate.
Each has an optimal temperature and pH.
O
Each has an active site.

Answers

Answer:

Each is used to break down substances.

Explanation:

Enzymes merely speed up a chemical reaction, not necessarily break down substances.

Each enzyme is used to break down substances is not a characteristic of enzymes. The correct option is A.

Thus, enzymes aren't just utilized to degrade things. Enzymes perform additional crucial tasks in addition to being essential for the breakdown (catabolism) of substances. In living things, enzymes operate as biological catalysts to quicken chemical processes.

Enzymes achieve this by reducing the activation energy needed for a reaction to happen and thereby speeding up the reaction rate. While some enzymes are engaged in the breakdown of chemicals, others are involved in the synthesis or modification of other molecules (anabolism).

Thus, the ideal selection is option A.

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can you please help me ​

Answers

Answer: 41. primary. 42. temporary storage. 43. secondary. brainliest?

Explanation:

Explain how where a person lives might affect his or her mood.

Answers

Answer:

When they go through something horrible for example (death,relationship break ups, and friendships ending etc.) that can affect their personality and their emotional stability they can also change to a whole different person.

Elizabeth is a schoolteacher. She is drawing a marine food chain on the board. Which marine organisms should be at the base of the chain?

Answers

Answer:

cyanobacteria, algae and marine plants.

Immediately after an action potential has peaked, which of the following channels will open?
A) Voltage gated potassium channels.
B) Chemically gated chloride channels
C) Voltage gated sodium channels
D) Voltage gated calcium channels

please give a brief explanation for each correct or incorrect

Answers

C) voltage gated sodium channels

have a great day!

What Kind of Mutation is demonstrated?

Answers

the answer is Translocation

A student is studying the levels of organization in living things and creates a table to give examples of the different levels.



Which of these should the student write as an example of the organism level of organization?


human

stomach

connective tissue

food, water, and air

Answers

Human because human is the only organism on the list!

HELP ME PLEASE!!!!!!

Answers

Answer:

C of course

Explanation:

You eat at chips and salsa at Qdoba. All that salt causes your cells to lose water through
osmosis. Your hypothalamus senses that your cells are shrinking
and sends a message to the
pituitary to release antidiuretic hormone. ADH sends a message to the kidneys to stop
releasing water in the urine. You also start to feel thirsty. The result is that your cell's water
level increases back to normal. This is an example of


A: Negative feedback
B: Positive feedback

Answers

Answer:

B

Explanation:

this is going to cause your body cells to hold water

• How does precipitation affect the topology of the earth?

Answers

Answer: Global Climate Change. comes from precipitation. Too little precipitation can result in dry soil, shallow streams, and shortages of municipal water supplies. However, too much precipitation can also have a negative impact on human activities, business and industry, agriculture, and the environment. As moist air is forced up the windward slope it expands and cools, eventually causing water droplets to condense when the air is saturated. These droplets form clouds and grow to produce rain or snow that typically falls out on the windward side of the range. ... As air approaches the topography, it slows down.

Explanation:

Precipitation affects the topology of the earth positively and negatively ( excess precipitation leads to soil erosion while moderate precipitation repairs broken/dry soil surfaces making it fertile )

Precipitation has a positive and negative effect on the topology of the earth because excessive precipitation like heavy rainfall causes flooding and the heavy movement of flood water, washes away the surface soil ( erosion ) which affects the topology of the earth negatively.   while

Moderate precipitation repairs dry and broken soil surfaces making the topology of the earth fertile, supporting the growth of plants and inhabitation of animals .

Hence we can conclude that precipitation affects the topology of the earth positively and negatively.

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Which cells in the body are targeted by HIV?

red blood cells

platelets

B cells

T cells

Answers

T cells. When HIV arrives in the lymph nodes – around 24 to 48 hours after exposure – they activate other immune cells, such as CD4 t-cells, HIV's primary target.
The answer is CD4 T-cells

Question 2
Which is a plausible solution to human activities contributing to increasing amounts of carbon dioxide in the atmosphere?
А
Use only alternative energies for the production of electricity
B
Require all new automobiles manufactured to run on electricity rather than gasoline.
с
Plant more trees and decrease deforestation practices so that more carbon dioxide can be absorbed from the atmosphere.
D
Require everybody to use mass transportation or methods of transportation that do not require burning fossil fuels, such as riding bicycles,
©2021 Illuminate Education Inc.

Answers

Answer:

hmm

Explanation:

On Earth, human activities are changing the natural greenhouse. Over the last century the burning of fossil fuels like coal and oil has increased the concentration of atmospheric carbon dioxide (CO2). This happens because the coal or oil burning process combines carbon with oxygen in the air to make CO2.

Plausible solution to human activities contributing to increasing amounts of carbon dioxide(carbon emission) in the atmosphere are :

Use only alternative energies for the production of electricity
Require all new automobiles manufactured to run on electricity rather than gasoline.
Plant more trees and decrease deforestation practices so that more carbon dioxide can be absorbed from the atmosphere.
Require everybody to use mass transportation or methods of transportation that do not require burning fossil fuels, such as riding bicycles.

What is carbon emission ?

Carbon emission (greenhouse gas emissions) from human activities strengthen the greenhouse effect, causing climate change. They cause climate change by trapping heat, and they also contribute to respiratory disease from smog and air pollution.

Alternative energy is energy that is collected from renewable resources that are naturally replenished on a human timescale, hence contributing to betterment of environment.
Electric automobiles do not cause carbon emission.
Trees absorb the carbon dioxide from the environment and release oxygen.
Mass transportation will cut the cut out the percentage of carbon emission by several folds.

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What is the most important factor in determining if cancer treatment will be successful?

Answers

You could say what stage the cancer might be if it is early stages the treatment would be successful

What is the term for creating a new species

Answers

Answer:

Speciation is the process by which new species form. It occurs when groups in a species become reproductively isolated and diverge. In allopatric speciation, groups from an ancestral population evolve into separate species due to a period of geographical separation.Explanation:

Is wetland salt water or fresh water ?

Or both

Estuary fresh water or salt water ? Or both

Ocean salt water or fresh water ?

Lake , river , stream , wetland , pond

Answers

The water found on wet lands is either brackish , fresh water or salt water the main wetland types are swamp , marsh and bog and fog and most wet lands are pet lands

What are the three
parts of the hair SHAFT?

Answers

Answer:

The hair shaft is comprised of three layers: the cuticle, cortex, and medulla.

Explanation:

Answer:

Hair shaft is consisted of three layers: cuticle, cortex and in certain cases medulla. Flat and square-shaped cuticle cells are adhered tightly to the cortex cells proximally.Explanation:

I mt.Kaboob were to erupt again what changes might you expect to see in the walking bean population ​

Answers

Answer: the. Population of the light red walking beans would grow because the red light from the explosion would help the light red kidney beans blend in.

How is climate and weather related and different?

Answers

Answer:

Weather and Climate is different because weather is what conditions the atmosphere over a short period of time, and climate is how the atmosphere behaves over relatively long periods of time. Weather and Climate is related because they both deal with temperature, air, pressure, humidty, wind, and precipitation

Explanation:

Which of the following particles has no charge?

A. Ion
B. Proton
C. Neutron
D. Electron

Answers

C.neutrons


Correct me if I’m wrong

Complete the following sentence.
When growing grapes, a(n) _________
is used to support the growing vines.

no options sorry
ag class plant systems

Answers

Answer:

An stick

Explanation:

because it needs support

Answer:

trellis

Explanation:

no balls

Rivers are more important to the water cycle than streams.
Please select the best answer from the choices provided
OT
OF

Answers

Answer:

this first option is the corect

This is a false statement. (:

write the compliment triplets for the DNA sequence in each box in the following “ATG, ATC, GCA, AGT, AGC, GCC, GAT, AAG, TTG, CAG, TAG

Answers

Answer:

The complementary DNA sequence of each triplet is as follows:

ATG - TAC

ATC - TAG

GCA - CGT

AGT - TCA

AGC - TCG

GCC - CGG

GAT - CTA

AAG - TTC

TTG - AAC

CAG - GTC

TAG - ATC

Explanation:

A double-stranded DNA molecule is made up of two strands of DNA whose sequence are complementary to one another and linked by hydrogen bonds. According to the complementary base pairing rule as postulated by Chargaff, Adenine base will always hydrogen pair with Thymine base while Guanine base will always hydrogen pair with Cytosine base i.e. A-T, G-C

Based on the above explanation, the following triplets of DNA will have the following complementary sequences:

ATG - TAC

ATC - TAG

GCA - CGT

AGT - TCA

AGC - TCG

GCC - CGG

GAT - CTA

AAG - TTC

TTG - AAC

CAG - GTC

TAG - ATC

Artesian springs bring pressurized groundwater to the surface through which feature of Karst topography?

streams

caves

fissures

igneous rock

Answers

Answer:

The correct answer is D) Fissures

Explanation:

Karst is a topography or landform that is created by the dissolution of soluble rocks beneath the surface by waters from the surface or below.

Fissures are formed when because of earth movements there is the occurrence of a long, narrow opening, in the earth.

Artesian springs refer to the water coming out through these cracks or openings in the earth onto the surface of the Karst topography.

Cheers

Please answer the questions that have “type here”

Earth science

Answers

Answer:

Earth science or geoscience is the study of the Earth's structure, properties, processes, and four and a half billion years of biotic evolution.  Understanding these phenomena is essential to the maintenance of life on the planet. There are four basic areas of Earth science study:

Geology: Science of the EarthMeteorology: Science of the AtmosphereOceanography: Science of the OceansAstronomy: Science of the Universe

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