As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9 mol/l). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7 mol/l).
1. Compute the total concentration of [D1]tot that is needed to bind 90% of the HIV-RT at the given concentration [E]tot. Provide your answer as a numerical expression with 3 significant figures in the unit mol/l. You do NOT have to consider competition betwwen the drugs D1 and D2! They are administered separately.
2. Compute the total concentration of [D2]tot that is needed to bind 90% of the HIV-RT at the given concentration [E]tot. Provide your answer as a numerical expression with 3 significant figures in the unit mol/l.You do NOT have to consider competition betwwen the drugs D1 and D2! They are administered separately.

Answers

Answer 1

Answer:

C)[D]/[ED] = 5.20

D)[D]/[ED] = 5.20

E)[D']_T = 1.495* 10 ^-7 M

F)[D'] / [ED']  = 0.0579

Explanation:

E = 250 nM =2.5* 10 ^-7 mol/L , T=298.15 K

Dissociation constant of K_D = 1.3 μM (1.3 *10 ^-6 M)

E + D ⇄ ED → K_a = [ED] / [D][E]   (association constant)

ED ⇄ E + D → K_D = [E][D] / [ED]  (dissociation constant)

C)

[E] =2.5*10^-7 mol/L

K_D = 1.3* 10^-6 M

K_D = [E][D] / [ED] → [D]/[ED] = K_D / [E]

= [D]/[ED] = 1.3* 10 ^-6 / 2.5 *10^-7

= 13/25 * 10

=130/25 = 5.20

[D]/[ED] = 5.20

D)

ΔG =RTln Kd

ΔG_2 for E and D = 1.987 * 298.15 * ln 1.3*10^-6

ΔG_2 592.454 * [ln 1.3 +ln 10^-6]

ΔG_1 = 592.424 [0.2623 - 13.8155]

ΔG_2 = -592.424 * 13.553

ΔG_1 = -8184.633 cal/ mol

ΔG_1 = -8184.633  * 4.18 J/mol = -34244.508 J?mol

ΔG_1 = -34.245 KL/mol

so, ΔG_2 = ΔG_1 - 10.5 KJ/mol

ΔG_2 = -34.245 - 10.5

ΔG_2 = -44.745KJ / mol

ΔG_2 =RT ln K_D

-44.745 *10^3

=8.314 *298.15 lnK_D

lnK_D' = - 44745 / 2478.81 g

ln K_D' = -18.051

K_D' = -18.051

K_D' = e^-18.051

[D]/[ED] = 5.20

E)

[E] = 2.5* 10 ^-7 mol/ L = a

K_D' = [E][D] / [ED']                                  E +D' → ED'

K_D' = a/2(x-(a/2) / (a/2)

KD' = x - a/2

=2.447 *10^-8 = (2.5/2) * 10^-7

x=2.447 * 10^-8 + 1.25 * 10^-7

x = 2.447 *10^-8 + 1.25 * 10 ^-7

x= 10^-7 [1.25 + 0.2447]

x = 1.4947 * 10^-7

[D']_T = 1.495* 10 ^-7 M

F)

K_D' = [E][D'] / [ED']

[D'] / [ED'] = KD' / [E]

[D'] / [ED'] = 1.447 *10^-8 / 2.5* 10^-7

[D'] / [ED'] = 0.5788 * 10^-1

[D'] / [ED']  = 0.0579

Explanation:

...


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A scientist hypothesizes that a new medication can reduce
the chances of catching a cold Which of these would most
likely be the dependent variable in a study involving this
medication?
//
The participants
who do not receive
the medication
Color PURPLE
The number of
participants who
catch a cold
Color YELLOW
The age of the
participants
Color GRAY
Tt remains the
T+ is purposely
It is used for

Answers

Answer:

what is the question????

Which one of the following is NOT the unit of wave number:

m-1
cm-1
mm-1
cm

Answers

Answer:

e

Explanation:

cm is not the unit of wave number out of the following.

What is a wave number?

Definition: Total number of wave cycles present in a unit distance is termed a wave number.

Wave number is always a reciprocal of the unit of distance.Wave number is denoted by the letter 'k'.The formula for wave number is  2π/λ where λ is the wavelength. Since wave number is always reciprocal, cm is not the unit for a wave number. The higher the wave number, the higher the frequency and energy.

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What is the Molality of a solution prepared by dissolving 84.7 g of KMnO4 (potassium permanganate, an oxidizing agent) in 165 g of water?
a) 0.513 m
b) 11.3 m
c) 0.308 m
d) 3.25 m
e) 0.958 m

Answers

your answer is d 3.25

which picture shows the particles in a compound?



picture I and II

picture I

picture III and IV

picture II

Answers

hi <3

compound are 2(or more) elements combined together

thus your answer will be picture I

hope this helps <3

A cylinder fitted with a movable piston and filled with a gas has a volume of 188.5mL at 26.7 °C when the applied pressure is 755.2 torr. The temperature of the oil bath surrounding the cylinder was increased to 165.2 °C, and the load on the piston was changed. Careful measurement now gave a value of 210.5mL for the volume. What was the final pressure in the system, in torr? Select one:
O a. 715.5 tor O b. 576.9 torr Oc. 988 6 torr O d. 1233 torr 462.6 tor

Answers

Answer:

C

Explanation:

To find the new pressure, we will use this formula: P₁V₁/T₁ = P₂V₂/T₂

P₁ = Original pressure (755.2)

V₁ = Original volume (188.5)

T₁ = Original temperature in kelvins (26.7 + 273.15 = 299.85)

P₂ = Final Volume (?)

V₂ = Final volume (210.5)

T₂ = Final temperature in kelvins (165.2 + 273.15 = 438.35)

Here is our equation

(755.2)(188.5)/(299.85) = (210.5)P₂/(438.35)

Hopefully, you have a calculator handy because this equation will end up looking like this:

474.75471 = (0.48021)P₂

Divide both sides by the coefficient

474.75471/0.48021 = (0.48021)P₂/0.48021

P₂ = 988.64

6. How many meters are in 0.00253 kilometers?

Answers

Answer:

2.53 kilometers

How do I calculate the volume?

Answers

Answer:

2477.6 cm³

Explanation:

Volume = length x width x height

Label in cm³

Determine the molecular and empirical formulas of the following:

a. the organic solvent benzene, which has six carbon atoms and six hydrogen atoms.
b. the compound silicon tetrachloride, which has a silicon atom and four chlorine atoms and is used in the manufacture of computer chips.
c. the reactive substance diborane, which has two boron atoms and six hydrogen atoms
d. the sugar called glucose, which has six carbon atoms, twelve hydrogen atoms, and six oxygen atoms.

Answers

Answer:

the answer is b im pretty sure

Explanation:

sorry if im wrong

The empirical formula for benzene is CH. The molecular formula for benzene is C[tex]_6[/tex]H[tex]_6[/tex]. The empirical formula is also known as the simplest basic formula.

What is molecular formula ?

A molecular formula is indeed a formula derived with molecules that corresponds to the total number of distinct atoms in the molecule of a chemical. A subscript inside a molecular formula denotes the number for each type of atoms in the substance's molecule.

The empirical formula provides the most basic formula for something like a compound, defined by the ratio between subscripts of the formula's smallest entire number of constituents. It is also known as the simplest basic formula. An empirical formula is the formula of a material given with the least integer subscript. The empirical formula for benzene is CH. The molecular formula for benzene is C[tex]_6[/tex]H[tex]_6[/tex].

Therefore, the molecular formula for benzene is C[tex]_6[/tex]H[tex]_6[/tex].

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In which way are the scientific method and the design process the same?

Answers

Answer: A lot of the steps are the same.

Explanation:

Scientific Method

State your question

Do background research

Formulate your hypothesis, identify variables

Design experiment, establish procedure

Test your hypothesis by doing an experiment

Analyze your results and draw conclusions

Communicate results

Steps of The Scientific Method

Engineering Design Process

Define the problem

Do background research

Specify requirements

Create alternative solutions, choose the best one and develop it

Build a prototype

Test and redesign as necessary

Communicate results

Steps of The Engineering Design Process

What are the variables used in an experiment? How are they different?

Answers

Answer:

There are many items that could be altered to test the reaction of another. These changing quantities are called variables. A variable is any factor, trait, or condition that can exist in differing amounts or types. An experiment usually has three kinds of variables: independent, dependent, and controlled.

Explanation:

1. Distinguish between a mixture and a pure substance. ​

Answers

Answer:

1)Mixture is the combination of substance

2)There are two types of mixture such as heterogeneous mixture and homogeneous mixture

3)foreg=Salt solution ,sedimentation

Pure substance

1)Pure substances are also called elements

2)They are made up of small atoms

3)for eg= oxygen,Venadium ,Iron,Oxygen

Which term best describes the important pieces of information that scientists gather and record during an experiment?
conclusions
data
research
supplies

Answers

Answer:

conclusions i think i am not confirmed

Answer:

b-data

Explanation:

right on the unit test review on edge

brainliest???

Solid calcium oxide and gaseous water are produced by the decomposition of solid calcium oxide hydroxide. Write a balanced chemical equation for this reaction.​

Answers

[tex]\boxed{\sf {Ca(OH)_2(s)\atop Calcium\:Hydroxide}\longrightarrow {CaO(s)\atop Calcium\;oxide}+{H_2O(g)\atop water}}[/tex]

On reactant side

Hydrogen= 2atomsOxygen=2atomsCalcium=1atom

On product side

Hydrogen=Oxygen=2atomsCalcium=1atom.

hence balanced.


Using the ruler, what is the value of A considering significant
figures?

Answers

Answer:

13.7 cm

Explanation:

If the number is between two whole numbers then that means it is going to be a decimal, how to determine the decimal is by how many ticks/lines are between it, so if you count from 13 cm and count each line as 1 you get to the number 7 and since that number is between the whole number it becomes 13.7

If the sum of the last
number and the middle
number of three consecutive
integersis is 71, then the
Least (smallest) number
mumber must be​

Answers

Answer:

number must be 0000.999

This picture shows students working in a
chemistry laboratory. What could they do to make
their lab safer?
Label the test tubes and plastic cups.
Move the fire extinguisher closer to their
table.
Wear chemical protective gloves.
Reduce the clutter on the table.
Stand at the table instead of sitting. Tie long hair back.
DONE

Answers

Answer:

yes it is true they apply necessary safety measures

Answer: Label the test tubes, wear chemical protective gloves, tie long hair back

Explanation:

Just got it wrong

What is an atomic number

Answers

Answer:

the number of protons is called the atomic number

hope it helps you buddy

Answer: number of protons in an atom

Explanation:

Hehe someone help I have put down heat but I think there is another

Answers

Answer:

chemical potential enery

Mark brainliest

name the types of polymerization and the differences​

Answers

condensation polymerization : releasing water as by product, occurs in monomer that has functional group that can react with each other e.g alcohol&carboxlic acid to form polyesters, carboxylic acid and amines to form polyamides,etc.

Radical Polymerization: occurs by propagating radical monomers or monomer that has unsaturated bonds, such as ethene, initiated by formation of radical from the monomer by using uv lights/other initiator, does not produce any by products

Arrange the following aqueous solutions in order of increasing boiling points.
0.050 m Mg(NO 3) 2; 0.100 m ethanol; 0.090 m NaCl
a. Mg(NO3) < NaCl < ethanol
b. ethanol < Mg(NO3)2 < NaCl
c. ethanol < NaCl < Mg(NO3)2
d. NaCl < ethanol < Mg(NO3)2
e. Mg(NO3)2 < ethanol < NaCl

Answers

Answer:

The correct choice is option b. ethanol < Mg(NO3)2 < NaCl

Explanation:

Ethanol = 0.100 m

Mg(NO3)2 = 0.15 m

NaCl = 0.18 m

The molar concentration of NaCl is the highest, which is why its boiling point will be the highest, too.

A student performs an experiment to determine the molar mass of magnesium oxide. The student repeats the experiment five times and collects the following data: 40.220gmol, 40.654gmol, 40.314gmol, 40.165gmol, and 40.554gmol. What is the relative standard deviation (RSD) for this set of data?

Answers

The relative standard deviation for the set of data obtained by the student is 0.470%

The formula for calculating the relative standard deviation is given below as:

Relative standard deviation (RSD) = (S * 100)/x

where S stands for the standard deviation and x is the mean of the data set.

The following are the steps to calculate to determine the relative standard deviation using the given formula:

Step 1: Calculate the mean of the numbers in the data set.

mean, x = sum of numbers / number of numbers

(40.220 + 40.654 + 40.314 + 40.165 + 40.554)/5

mean = 40.381 g/mol

Step 2: Subtract the mean from each number in the data to determine the deviation for each number and then square the deviations.

(40.220 - 40.381)² = 0.0259

(40.654 - 40.381)² = 0.0745

(40.314 - 40.381)² = 0.00449

(40.165 - 40.381)² = 0.0466

(40.554 -40.381)² = 0.0299

Step 3: Sum the squared deviations.

0.0259 + 0.0745 + 0.00449 + 0.0466 + 0.0299 = 0.181

Step 4: Determine the variance by dividing the sum of the squared deviations by the total number of values.

Variance = 0.181/5 = 0.0362

Step 6: Determine the standard deviation of the data by taking square root of the variance.

Standard deviation, S = √0.0362 = 0.190

Step 7: Determine the relative standard deviation by inserting the values in the formula, (RSD) = (S * 100)/x

RSD = (0.190 * 100)/40.381

RSD = 0.470%

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20,000 $ give a way but answer this first
Plz




12.Write the basis of naming of the following elements. 1.Neptunium,2.Mendelevium,​

Answers

Answer:juhygjdkeExplanation:

Mendelevium is named for Dmitri Mendeleev who produced one of the first periodic tables.

Abelson first found neptunium in 1940 after uranium had been bombarded by neutrons from the cyclotron at Berkeley, California. ... The element was named after the planet Neptune, which is the first planet beyond Uranus.

Answer in explanation

Explanation:

neptunium was named after the discovery of the planet neptune in september 23 1846

mendelevium was named as dimitri mendeleev

A pycnometer is a glass apparatus used for accurately determining the density of a liquid. When dry and empty, a certain pycnometer had a mass of 27.056 g. When filled with distilled water at 25.0°C, it weighed 36.773 g. When filled with chloroform (a liquid once used as an anesthetic before its toxic properties were known), the apparatus weighed 41.451 g. At 25.0°C, the density of water is 0.99704 g/mL

Answers

Complete Question

A pycnometer is a glass apparatus used for accurately determining the density of a liquid. When dry and empty, a certain pycnometer had a mass of 27.056 g. When filled with distilled water at 25.0°C, it weighed 36.773 g. When filled with chloroform (a liquid once used as an anesthetic before its toxic properties were known), the apparatus weighed 41.451 g. At 25.0°C, the density of water is 0.99704 g/mL

-What is the volume of the pycnometer (mL)

 

We have that the volume of the pycnometer in mL is

[tex]V=9.111mL[/tex]

From the Question we are told that

Pycnometer mass of [tex]m_p=27.056 g.[/tex]

Temperature [tex]T=25 \textdegree[/tex]

Pycnometer filled with distilled water [tex]m_{pf}= 36.773 g[/tex]

Apparatus weighed [tex]w=41.451 g[/tex]

Density of water [tex]\rho= 0.99704 g/mL[/tex]

Generally the equation for Density  is mathematically given as

[tex]\rho=\frac{mass}{Volume}[/tex]

Since pycnometer is filled with water its volume can be defined by the volume of water in it

Therefore

Mass of water Pycnometer filled with distilled water-Pycnometer mass

[tex]M_w=36.773 -27.056\\\\M_w=9.084g[/tex]

Hence

[tex]V=\frac{9.084g}{0.99704 }[/tex]

[tex]V=9.111mL[/tex]

in conclusion

The volume of the Pycnometer in mL is

[tex]V=9.111mL[/tex]

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Which of the following are considered elements:

Answers

Answer:

considered as element

Helium He

how many grams are in one mole of CH3CO2H ?

Answers

Answer: 60.2g

Explanation:

One mole acetic acid weighs 60.2g

How many atoms? H_____, O_____, Fe_____ Total atoms? _____ 3Fe(oh)2

Answers

Answer:

H = 6

O = 6

Fe = 3

Total atoms = 15

Explanation:

3Fe (OH)2

Fe = 1×3

O= 2× 3 = 6

H= 2× 3 = 6

Total atoms = 6+6+3=15

I hope I helped you^_^

13. Find the total number of atoms present in the following molecules.
a. 5 H₂O
b. Zn Cl₂​

Answers

Answer:

zxcdfzdg

Explanation:

zszghzd

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