Cystathioninuria can be caused by two different mutations in the enzyme cystathionase. Cystathioninuria caused by mutation 1 can be overcome by providing cells with increasing concentrations of the coenzyme pyridoxal phosphate. Which of the following statements describe the most likely changes in the binding affinities of the two mutant enzymes?
A. Both mutant enzymes have lost the ability to bind the substrates.
B. The enzyme with mutation 1 has lost the ability to bind to the substrates, whereas the enzyme with mutation 2 has lost the ability to bind to pyridoxal phosphate.
C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.
D. Both mutant enzymes have lost the ability to bind pyridoxal phosphate.

Answers

Answer 1

Answer:

C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.

Explanation:

A coenzyme is an organic cofactor that binds with an enzyme in order to initiate or aid the function of the enzyme. A coenzyme binds to the active site of the enzyme (where the reaction occurs), thereby triggering its activation by modifying protein structure during the reaction. Some examples of coenzymes include Coenzyme A and Adenosine triphosphate (ATP). Pyridoxal phosphate is a coenzyme (it is the active form of vitamin B6) that is required for the function of cystathionase. Moreover, cystathionase is an enzyme that enables cells the synthesis of cysteine from methionine (transsulfuration pathway). The binding of pyridoxal phosphate to the enzyme increases the binding affinity of the enzyme for the substrate, thereby influencing its activity. In this case, it is expected that mutation 1 reduces the binding affinity of the enzyme to the cofactor, and thereby the cofactor is required at a higher concentration to restore normal enzyme activity.


Related Questions

What is Anatomy and physiology

Answers

Answer:

Anatomy: The branch of science concerned with the bodily structure of humans, animals, and other living organisms, especially as revealed by dissection and the separation of parts.

Physiology: The branch of biology that deals with the normal functions of living organisms and their parts.

Explanation:

Anatomy = The science that deals with the form and structure of organic bodies; anatomical structure or organization is Anatomy.

Physiology = A branch of biology that deals with the functions and activities of life or of living matter (as organs, tissues, or cells) and of the physical and chemical phenomena involved is Physiology.

Hope it will help:)❤️

For each of the following structures, first indicate its function in the fetus; then, note its fate (what happens to it or what it is converted to after birth).

a. Umbilical artery
b. Umbilical vein
c. Ductus venosus
d. Ductus arterious
e. Foramen ovale

Answers

Answer:

1. Functions:

a. Umbilical artery >> carries deoxygenated blood from the fetus to the placenta

b. Umbilical vein >> transports oxygenated blood from the placenta to the fetus

c. Ductus venosus >> allows oxygenated blood from the placenta to bypass the liver

d. Ductus arterious >> allows most of the blood from the right ventricle to bypass the fetus's non-functioning lungs

e. Foramen ovale >> oxygenated blood from the umbilical vein to bypass the pulmonary circulation

2. After the bird:

1. Umbilical artery >> medial umbilical ligament

2. Umbilical vein >> round ligament of the liver

3. Ductus venosus  >> ligamentum venosum

4. Ductus arteriosus >> ligamentum arteriosum

5. Foramen ovale >> fossa ovalis

Explanation:

The umbilical artery is a paired artery localized in the abdominal and pelvic regions, which carries deoxygenated blood from the fetus to the placenta through the umbilical cord. The medial umbilical ligament is the obliterated part of the umbilical artery that arises from the internal iliac arteries. In utero, the umbilical arteries carry waste products back to the placenta, whereas the umbilical vein carries oxygenated blood from the placenta to the fetus. The round ligament of the liver (also known as ligamentum teres hepatis) is a remnant of the umbilical vein that  exists in the embryonic stage, it connects the left lobe of the liver to the umbilicus. The ductus venosus is a slender shunt that allows oxygenated blood from the placenta to bypass the liver, it connects the intra-hepatic portion of the umbilical vein to the inferior vena cava. The ligamentum venosum is an extrahepatic, slender, and fibrous remnant of the fetal ductus venosus that travels between the left portal vein and the inferior vena cava. The ductus arteriosus is a fetal artery that connects the aorta to the pulmonary artery. The ligamentum arteriosum is a nonfunctional vestige of the ductus arteriosus, it is attached to the superior surface of the pulmonary trunk. The foramen ovale is an oval-shaped, small, opening in the wall (septum) between the two upper chambers of the heart. The fossa ovalis is a vestige stricture of the foramen ovale of the embryonic heart, which forms a depression in the right atrium of the heart.

Lymph ______ are found throughout the body and are a signal of a disease, infection, or problem if they become and remain swollen for long periods of time.
______ are pathogens that cannot be killed with antibiotics because they are non-living. They take over cellular organelles to replicate and spread.
Because they are also eukaryotes with their own cell membranes and membrane-bound organelles, ______ are often difficult to combat with medicines.
A cell signal called ______ is produced by mast cells. These molecules cause more fluid to spread to an infected area.
_______ are the types of cells that produce antibodies.
All pathogens have unique identifying molecules on their surfaces called ______. Antibodies bind to these, and targeting the pathogen to be destroyed by the immune system.
______ is a non-specific response to disease, in which the body temperature rises

Answers

Answer:

nodes

Viruses

fungi

histamine

B-cells

antigens

Fever

When a paper cut breaks the skin, it introduces outside microorganisms into the cut. The body recognizes the break in the skin. Mast cells produce histamines, which cause more blood and lymph fluid to flow to the wound. This increased flow brings phagocytic white blood cells to the area, which destroy invading organisms until the blood can clot and the skin can heal over the cut, preventing more organisms from entering the body. If a cut is too deep or too wide, special care such as stitches and antibiotics could be needed to prevent infection.

Explanation:

PENNFOSTER !

List five Characteristic of fruits.​

Answers

Answer:

Quality factors for fruits include the following— maturity, firmness, the uniformity of size and shape, the absence of defects, skin and flesh color.

Explanation:

Hope this helps. Have a nice day.^_^

Answer:

the five characteristics of fruit are:- maturity, firmness, the uniformity of size and shape

which of the following is a density- independent factor?
1 mate availability
2 parasitic infestation
3 disease transmission
4 lack of rainfall

Answers

Answer:

4. Lack of Rainfall

Explanation:

the matter in an animal body is not capable of moving and changing without ?

Answers

Answer:

Energy

Explanation:

The matter in an animal body is not capable of moving and changing without energy.

the body is not capable of moving without energy .

why is growth important to living things?​

Answers

Answer:

However, growth in living things is because of different internal processes occurring inside the body of the living organisms mainly because of the formation of new cells. The increase in number and mass of individuals are two unique characteristics of growth. Multicellular organisms exhibit growth by cell division.

Which statement is not true about the field of science?
it is based on observations and explanations of the natural world.

Answers

You are right with your answer please

Actual Question:
Which statement about the purpose of the field of science is false? (1 point)

Science is used to investigate the natural world.

Events of the natural world can be explained by science.

Science works to establish a collection of unchanging truths.

Useful predictions come from derived explanations of science.
Answer:

Science works to establish a collection of unchanging truths.

Explanation:

I took the test

4. What is the best type of graph to show the proportion of dogs that are poodles, labs,
golden retrievers, and beagles.
A. Pie graph
B. Bar graph
C. Line graph
D. Histogram

Answers

Answer:

I think a bar graph or a pie graph

Pie graph because it shows percentage

Role of mitosis in plant growth and development

Answers

Answer:

The mitosis cell division helps in vegetative growth in plants. It also helps in healing of wounds

how are traits which are not beneficial to a living organism removed from its gene pool

Answers

Answer:

recessive traits is the answer

Organisms who carry those traits are less likely to be chosen as a mate, slowly reducing that gene from the species

The second generation of purebred cross of -hom-ozygo us recessive organism, with a —hom-ozygous dominant organism, contain a ratio of approximately _______ expressed dominant traits to recessive traits.
A. 2:1
B. 1:1
C. 1:3
D. 3:1

Answers

Answer:

D. 3:1

Explanation:

Gregor Mendel, in one of his numerous studies, performed a cross between purebred dominant (TT) pea plants and purebred recessive (tt) pea plants. All the offsprings of this cross appeared heterozygous tall (Tt) in the F1 generation.

However, when he self-crossed the F1 generation i.e. Tt × Tt, Mendel obtained a phenotypic ratio of 3 tall plants (dominant traits) : 1 short plant (recessive). This showed that the masked gene (recessive) was still present.

which climate does sparrow live hot or cold

Answers

Answer:

Hot ok please give me brilliance

Explanation:

please

Marianela takes a huge drink of her coffee, assuming that it is at a tolerable temperature, and the heat sears her mouth. Although the pain is so great that her reflex is to spit out the coffee, she does not do so. The reflex to spit out the coffee is inhibited at the

Answers

Answer:

This question lacks options, options are:

A) glial cell

B) interneuron

C) sensory neuron

D) motor neuron.  

The correct answer is D.

Explanation:

The brain sends instructions to the muscles that control voluntary movement through nerve cells called motor neurons. The function of the motor neuron is basically to carry the information that comes from the descending pathways of the spinal cord, in order to generate an activation in the tissues of the skeletal and visceral muscles of all parts of the body. Motor neurons need the information sent to them by sensory or efferent neurons. Since in order to perform the appropriate muscle movements for the situation, our brain must receive information from the outside. By sending sensory stimulation through interoreceptors, motor neurons can regulate visceral activity, stimulating or inhibiting the activity of their effector tissues. In this way, our nervous system integrates the information from both types of neurons and allows us to move and react according to the demands and circumstances of our external context.

Is the podocyte process of the glomerular capillary wall the same as the endothelial layer?

Answers

Answer:

The podocytes have long foot processes called pedicels, for which the cells are named (podo- + -cyte). The pedicels wrap around the capillaries and leave slits between them. Blood is filtered through these slits, each known as a filtration slit or slit diaphragm or slit pore.

What are micronutrients and why do we need them?

Answers

Explanation:

Micronutrients are one of the major groups of nutrients your body needs. They include vitamins and minerals. Vitamins are necessary for energy production, immune function, blood clotting and other functions. Meanwhile, minerals play an important role in growth, bone health, fluid balance and several other processes.

if my answer helps you than mark me as brainliest.. thanku

1. Sensation is to as perception is to a. vision, olfaction b. conscious, unconscious c. awareness, interpretation d. taste, vision.​

Answers

Answer:

opt (c)

Explanation:

What allows humans to have different traits from each other?
A. They store DNA in different places.
B. They have different genes.
C. They have different haploidnumbers.
gling
D. They have different number
Ichromosomes.
SUBMIT

Answers

Answer:

B. They have different genes.

Explanation:

What is the correct chronological order of the steps leading to protein synthesis?
rRNA, mRNA, DNA, protein
mRNA, DNA, rRNA , protein
DNA, mRNA, rRNA, protein
rRNA, DNA, mRNA, protein

Answers

Answer:

the third option is the right one.

Explanation:

m RNA gets its information from DNA and then sends it to rRNA which will later turn the message into a protein.

QI the father
13. A father and mother claim they have been given the wrong baby at the hospital. Both parents are
blood type A. The baby they have been given is blood type o. Does the genetic evidence support
their claim?

Answers

No, the claim is not based on scientific evidence because to heterozygous parents with genotype AO may have offspring with O phenotype and therefore OO genotype (proportion 1/4 of descendence).

What is the ABO blood type?

The ABO blood type is a group of phenotypes controlled by a single locus, which is based on the alleles that encode surface antigens in red blood cells. The O phenotype is due to the recessive allele, while the A allele is dominant and therefore masks the O allele in heterozygous individuals.

Therefore, we can conclude that parents having the AO genotype may produce offspring with OO genotype

Learn more about the ABO blood type here:

https://brainly.com/question/3221452

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7. Which substances are produced by the hydrolysis of an
oil?
(1) water and nucleic acids
(2) amino acids and dipeptides
(3) fatty acids and glycerol
(4) glucose and water

Answers

Answer:

3) Fatty acids and Glycerol

The data table and the cladogram below provide information about the evolutionary history of several different species of animal. Using this information, which of the following is true of trout?

They are more closely related to salamanders than they are to birds.

They are more evolved than salamanders and lizards.
They evolved into a separate species due to the presence of lungs.
They have jaws and lungs but lack claws or nails, feathers, and mammary glands.

Answers

Answer:

They are more closely related to salamanders than they are to birds.

Explanation:

According to the data, trout are more closely related to salamanders than birds.

The first data table shows how the salamander only has one extra trait that the trout does not have (lungs).

On the other hand, birds have three extra traits that the trout doesn't have (claws/nails, feathers, and lungs).

The cladogram further shows how trout are more closely related to salamanders compared to birds.

Trout and the salamander are closer together on the cladogram, while the bird is further away. This means they are more related on the evolutionary timeline.

So, the correct answer is that They are more closely related to salamanders than they are to birds.

The statement which is true about Trout is as follows:

They are more closely related to salamanders than they are to birds.

Thus, the correct option is A.

What is Cladogram?

A Cladogram may be defined as a type of family tree or classification tree which is based on evolutionary relationships. It is also known as a phylogenetic tree.

Trout and the salamander are positioned closer to one another on the cladogram while the bird is being far away. The presence of lungs is marked from the salamander, so trout do not have lungs.

Trouts evolved from Hagfish but not from salamanders and lizards. Trouts only have jaws but lungs, claws or nails, feathers, and mammary glands.

Therefore, the correct option for this question is A.

To learn more about Cladogram, refer to the link:

https://brainly.com/question/12275760

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Which of the following controls the involuntary actions in the body​

Answers

medulla oblongata

Involuntary actions are under the voluntary control of the medulla oblongata which is generally referred to as the midbrain. The involuntary movements are characterised by relatively slower speed. The best example of this movement is the beating movement of the human heart.

Raw materials required in the autotrophic mode of nutrition involve:​

Answers

Answer:

Water,mineral salts and carbon dioxide

Which part of plant carries water and minerals from roots to other parts of the plant

Answers

Answer: The xylem distributes water and dissolved minerals upward through the plant, from the roots to the leaves. The phloem carries food downward from the leaves to the roots. Xylem cells constitute the major part of a mature woody stem or root.

explain how typical cells are adapted to their function​

Answers

Answer:

Many cells are specialized. They have structure that are adapted to their function. For eg : muscle cells bring parts of the body together. They contain protein fibres that can contract when energy is available, making the cells shorter.

hi can u Help me in my hw, Define the following terms:1)Epicenter 2)Seismograph(don't answer if u don't know the answer plz)​

Answers

Answer:

Epicenter is the point on Earth's surface directly above the focal point of the earth quake.

Actually it's above the hypocenter.

Seismograph: Is an instrument that records the seismic waves caused by action of earth quake effect.

HELP ASAP I WILL GIVE BRAINLIST

The picture shows two containers filled with a gas, both initially at room temperature.

Which statement is correct?

The gas particles in both containers have the same average kinetic energy because they have equal number of particles.

The gas particles in both containers have the same average kinetic energy because they have the same volume.

The average kinetic energy of the gas particles is greater in container A because it has a lower temperature.

The average kinetic energy of the gas particles is greater in container B because its particles move faster.

Answers

Answer:

1) CO₂

2) 0.2551 g

Explanation:

The balanced reactions are:

CaCO₃ + 2HCl → CaCl₂ + H₂O + CO₂

MgCO₃ + 2HCl → MgCl₂ + H₂O + CO₂

1) The gas produced is CO₂.

2) Calculate mass of CaCO₃:

(0.5236 g) (0.4230) = 0.2215 g CaCO₃

Convert to moles:

(0.2215 g CaCO₃) (1 mol / 100.1 g) = 0.002213 mol CaCO₃

Find moles of CaCO₃:

(0.002213 mol CaCO₃) (1 mol CO₂ / mol CaCO₃) = 0.002213 mol CO₂

Convert to mass:

(0.002213 mol CO₂) (44.01 g / mol) = 0.09738 g CO₂

Calculate mass of MgCO₃:

(0.5236 g) (0.5770) = 0.3021 g MgCO₃

Convert to moles:

(0.3021 g MgCO₃) (1 mol / 84.31 g) = 0.003583 mol MgCO₃

Find moles of MgCO₃:

(0.003583 mol MgCO₃) (1 mol CO₂ / mol MgCO₃) = 0.003583 mol CO₂

Convert to mass:

(0.003583 mol CO₂) (44.01 g / mol) = 0.1577 g CO₂

Total mass of CO₂:

0.09738 g CO₂ + 0.1577 g CO₂ = 0.2551 g CO₂

Answer:

The average kinetic energy of the gas particles is greater in container B because its particles move faster.

Explanation:

PLEASE HELP ASAP FAST

Answers

Answer:

B.UAA is correct answer

What. Is black i will mark as brinelist ​

Answers

Just black?
Well it’s a colour which results from the absence of visible light. In technical sense black and white aren’t colour, but shades however, many people disagree since you combine other pigments to get black. Black is also associated with darkness, evil, despair and night (if it’s Literature related). It’s the darkest shade and it’s an achromatic colour.

simple. black. Is a color and it is dark

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using trig to solve for the missing angle which primitive organic molecule was essential to form lipid bilayer? Researchers studied symptom distress and palliative care designation among a sample of 710 hospitalized patients. Controlling for age, they used a t-test to compare average distress from nausea scores in men and women. Lower scores indicated less distress from nausea. They report men had an average score of 1.02 and woman had an average score of 1.79. Which statement is correct?(2pts)Select Men had significantly less distress from nausea. as your answerMen had significantly less distress from nausea.Select Men had half as much distress from nausea as woman but we can not determine if this is a significant difference. as your answerMen had half as much distress from nausea as woman but we can not determine if this is a significant difference.Select Men had less distress from nausea on average than women but we can not determine if this is a significant difference. as your answerMen had less distress from nausea on average than women but we can not determine if this is a significant difference.Select There is a positive correlation between distress from nausea and gender. as your answerThere is a positive correlation between distress from nausea and gender. 1. alveoli, tiny air sacs within the lungs muscle below the lungs used for, 2. bronchi, breathing the two tubes into which the, 3. diaphragm, trachea divides before entering the lung What is the recursive rule for this geometric sequence? 7, 21, 63, 189,1. a1 = 7;an = 3 an - 12. a1 = 7;an = 1/3 an - 13. a1 = 3;an = 7 an - 14. a1 = 21;an = 7 an - 1 HELP!!!!!!!!!!!!!!!!!!!!!!!!!! What is the median of 12, 9 , 16, 1, 6 , 5, 84 -3x^5y^7/6xy^8PLEASE HELP laws of thermodynamics Cho bit tan ca NH4Cl trong nc 20oC v 70oC ln lt l 37,2 g/100 gam nc v 60,2 gam/100 g nc. Ha tan 166,8 gam NH4Cl vo 400 gam nc 70oC thu c dung dch X. Sau , h nhit dung dch X xung 20oC. Tnh khi lng (gam) NH4Cl kt tinh li trong X? Please help with the Volume one Which of the following functions best describes this graph? y=(x+2)(x+7) There are two main methods of child study used todaythe ______________ and the __________ methods. Read the following paragraph and answer the question: "Beth lay in bed unable to fall asleep. Hereyes darted around the dark room. The wind roared causing the tree branch to scrape her windowwith an ear piercing scream. Suddenly she heard something coming up the steps. Thump, thump,thump, it was getting closer. She tightly squeezed her eyes shut as the door slowly creaked open.Which sentence gives an example of personification?A. Her eyes darted around the dark room.B. The wind roared causing the tree branch to scrape her window with an ear piercing scream.C. She tightly squeezed her eyes shut as the door slowly creaked open.D. Thump, thump, thump, it was getting closer. What does the underlined word mean in the following sentence?Salgo de la heladera muy satisfecha.ice cream parlorsupermarkettoy storeflower shop Venn diagrams: unions, intersections, and complementsAttached is the photo reference what would the equation, slope, and point be for this graph? In this diagram,which equation could prove to be true in order to conclude that the lines are parallel? which of the following statements is true concerning the racial and ethnic composition of the us Graph the line that passes through (5, 5), and is perpendicular to a line whose slope is 2.