Further studies of the genes in the region around the MHC locus identified C4 as a likely causative gene. A particular allele of C4 was significantly associated with schizophrenia. In addition, it was found that individuals with high expression of this allele of C4 had elevated risk of developing schizophrenia. Which of the following variants would be most likely to increase risk of schizophrenia from this allele?

a. a variant that decreases binding of an activating transcription factor to the C4 promoter
b. a 5’ UTR variant that destabilizes the C4 mRNA
c. a duplication of the C4 gene
d. a nonsense coding variant

Answers

Answer 1

Answer:

c. a duplication of the C4 gene

Explanation:

Schizophrenia is a disease that affects the brain, which is characterized by an imbalance of neurotransmitters and the presence of damaged brain tissues. In humans, the Complement component 4 (C4) protein is found at the neurons (i.e., cell bodies, dendrites and axons), which are the most common brain cells, and neuronal synapses. Moreover, gene duplication can increase gene expression when repressive mechanisms (e.g., DNA methylation at promoter sites) capable of silencing the expression of the duplicated gene are lacking. Recently, it has been discovered that a chromosome rearrangement associated with a tandem duplication of a genomic region that contains a C4 gene may contribute to schizophrenia risk by increasing the expression of this gene​. In this example, a, b and d options are associated with a decrease in expression of the C4 gene, either by decreasing its transcription (options a and d) or by posttranscriptional mechanisms (option c).


Related Questions

The importance of water properties on plants and animals​

Answers

Question:

The importance of water properties on plants and animals.

Answer:

The importance of water in plants is that it helps plants to make their own food, because water plays a very important role in Photosynthesis, and as well it helps them to grow.

The important of water in animals is that it is main need for animals to survive as well as humans. Without water even a single organism won't exist in this Earth.

Hope it helps you

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The human body is made up of more than three-fourths of water, and all animals and plants require water to thrive.

Why water is essential for plants and animals​?

Water is used by all living things to transport nutrients throughout the body and remove waste. Among its many crucial functions, water aids in the digestion of food and the preservation of organisms' heat.

The term "universal solvent" refers to water's enormous capacity to dissolve a wide range of molecules, and it is this capacity that makes water such a priceless life-sustaining agent.

Water's function as a solvent aids cells in the transfer and utilization of molecules like oxygen or nutrients on a biological level.

Therefore, to do all the cellular processes by plants and animals there is need of water.

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Which of the following events contributes to the termination of a signal generated by the binding of a ligand to a receptor tyrosine kinase? Only one answer is correct
1. Phosphatases hydrolyze key phosphorylated residues.
2. Kinases hydrolyze key phosphorylated residues.
3. Kinases phosphorylate key residues.
4. The receptor tyrosine kinase dimerizes.
5. GTPase removes a phosphoryl group from GTP.
6. Phosphatases phosphorylate key residues.

Answers

Answer:

1. Phosphatases hydrolyze key phosphorylated residues.

Explanation:

Receptor Tyrosine Kinases (RTKs) are high-affinity transmembrane protein receptors that bind to a wide variety of ligands (e.g., growth factors, cytokines, hormones). These receptors (RTKs) have a transmembrane domain and therefore these proteins act as membrane receptors, as well as exhibit catalytic activity. The intracellular C terminal region of RTKs contains catalytic domains responsible for both autophosphorylation and tyrosine phosphorylation of their protein substrates. Moreover, Protein Tyrosine Phosphatase (PTPs) are critical enzymes that remove phosphate groups from tyrosine residues in different substrates (including RTKs), thereby regulating key signaling pathways such as cell proliferation, cell differentiation, and cell-cell adhesion.

P is an autosomal dominant allele that produces a pigment, p is a recessive allele that produces no pigment. A pigmented and a non-pigmented organism mate and produce a pigmented offspring. They then mate and produce a non-pigmented offspring. What is the probability the next offspring will be pigmented

Answers

Answer:3/4

Explanation:4 possibilities, 3 dominant

If a pigmented and non-pigmented organism mate and produce a pigmented organism, which mate again and produce non-pigmented organisms, the probability that the next offspring will be pigmented is ¾ as P is the dominant, pigment-producing allele.

What are dominant alleles?

The association between two genetic variants is referred to as dominant. Each gene has two alleles that an individual inherits from each parent. One allele of a gene, known as the dominant gene, will be expressed if the alleles are different. The impact of the additional allele, known as the recessive one, is concealed.

If one is in charge, the other must be recessive. Then it is referred to as recessive. A dominant gene, or dominant form of a gene, is a specific variant of a gene that expresses itself more powerfully on its own than any other version of the gene that the individual is carrying—in this example, the recessive—for a variety of reasons.

Now, it mainly refers to patterns of inheritance typically used in combination with a Punnett square, where if a person has two copies of a gene and one is shown to frequently be passed down from one generation to another, it is referred to as dominant.

According to biochemistry, what is happening in this situation is that the genetic variant may, for a variety of reasons, cause a cell to perform a very advantageous or very disadvantageous function that the other version of the gene cannot cover up or counteract.

Therefore, the probability that the next offspring will be pigmented is ¾ as P is the dominant, pigment-producing allele.

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1. What features are located medial to the cranium and the mandible. Identify the category here.
2. How many individual items are included in this category?

Answers

The features that are located medial to the cranium and the mandible are:teeth,tongue, lips, chick hard andsoft palate,

   2. There is a total of six individual items in this category.

The human skull is made up of two parts, the cranium, which contains the face and the brain and the only movable bone called the mandible or lower jaw.

The features that are medial to the cranium and the mandible are those structures that are nearer to the mid-line.

The above mentioned features works together to provide the following functions of the cranium:

protection of the delicate structures including the brain, eye and the inner ear.maintaining patency of the nasal passage enabling breathing.the movement of the mandible allows chewing.

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Below is a mature eukaryotic mRNA transcript. Translate this mRNA into a protein, also showing the tRNA anticodons involved. Make sure you start and end translation in the right place! Label the ends of the polypeptide chain as N and C terminus.
mRNA: 5'GMUUACAUGCGGCUCAGUUGAGGCGAAAAAA 3'
tRNA:
amino acids:

Answers

Answer:

mRNA ⇒ 5'GMU  UAC  AUG  CGG  CUC  AGU  UGA  GGC  GAA  AAA  A 3'

tRNA ⇒                           UAC  GCC  GAG  UCA  ACU

protein ⇒ N - MET   ARG   LEU   SER   Stop - C

Explanation:

In protein synthesis, the ribosome reads mRNA in the 5´ to 3´ direction, and, according to the codons that are being readen, tRNA transfers the correct amino acids to build the polypeptide chain. A codon is a short sequence of three nucleotides that store the genetic information for the aminoacids´ assembly. Each tRNA has two important sites. One of them that couples with the codon of the mRNA molecule, named anticodon. The other site couples with an amino acid. tRNA allows amino acids to align according to the nucleotidic sequence in the mRNA molecule.  

Once the new amino acid links to the growing peptidic chain, the binding between the amino acid and the tRNA molecule breaks. The tRNA is now free to join another amino acid and repeat the cycle.  

The protein is synthesized from the amino terminus to the carboxy terminus, while the added amino acids to the chain are coded by a codon formed by three bases in the mRNA. mARNs also have a start and end codon that are the signals of the synthesis initiation and finish. When the ribosome reaches the end codon, protein synthesis is over.    

Each of the codons represents one of the 20 amino acids used to build the protein. Each amino acid can be codified by more than one codon. From the total 64 codons, 61 codify amino acids, and one of them is a start codon. The left three codons are stopping translation points.

The codons indicating the initiation or stop points during the translation process are:

• The start codon AUG is the most common sequence used by eukaryotic cells and places near the 5´extreme of the molecule.  

• The end codons are UAA, UAG, UGA.

Protein synthesis initiates in the AUG start codon -Metionin-, and ends when reaching either of the stop codons UAA, UAG, UGA.

In the exposed example we have the following mRNA.

mRNA ⇒ 5'GMU  UAC  AUG  CGG  CUC  AGU  UGA  GGC  GAA  AAA  A 3'

Codons are separated by a space left between them. AUG is the start codon placed near the 5´ extreme. UGA is the end codon near the 3´ extreme. tRNA will add amino acids from the start codon, not before.

tRNA ⇒ UAC  GCC  GAG  UCA  ACU

Anticodons are separated by a space left between them.

protein ⇒ N - MET   ARG   LEU   SER   Stop - C

Each mRNA codon codifies for an amino acid. The start codon codifies for methionine. AUG = Met, CGG = Arg, CUC = Leu, AGU = Ser, UGA = Stop codon. The amino terminus is represented as an N and the carboxy terminus is a C. The first extreme to be translated carries the amino-terminal group, while the other extreme carries the carboxy-terminus group.

que contiene el condón?

Answers

Answer:

plss translate it in English so i Can easyly answer it.

Explanation:

Thank you.

define cell and atom.....​

Answers

Cell: A cell is the structural and fundamental unit of life. The study of cells from its basic structure to the functions of every cell organelle is called Cell Biology.

Atom:  atom is the smallest component of an element, characterized by a sharing of the chemical properties of the element and a nucleus with neutrons, protons and electrons. The protons and the neutrons reside in the nucleus.

whats the difference between atom and cell?

function wise atoms take part in every chemical reaction while cells are responsible for the development and growth of living existences. Atoms do not have life. They do not need food, water, and they do not reproduce. Cells are alive. Cells consume food and water and can reproduce. Atoms construct molecules and Cells make tissues for organs.

2 True or False. A projectleie an object that once set in motion continues in motion by its own martia O True False ​

Answers

Answer:

The answer is true.Explanation:PARTICLES MOVING ALONG THE PATH POSSES A TWO DIMENSIONAL MOTION

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5. The major functions of carbohydrates irſclude
A. Structure framework. B. Storage C. Both Aan B
D . None of these​

Answers

Answer:

D

Explanation:

used to provide energy to the body

Consider the following statements:
1. RNA is ribonucleic acid.
2. RNA is used for information transport (known as mRNA). Choose the correct answer from the given codes:
A Only 1
B Only 2
C Both
D Neither 1 nor 2
E None of the above

Answers

Answer:

Only A

Explanation:

RNA is used for storing and transporting information through mostly virus only..

Many of the phenotypes of DiGeorge syndrome have been traced back to one of the genes that is in the deleted region, TBX1. Some of the evidence for the important role of TBX1 in DiGeorge syndrome came from individuals who have some of the symptoms of DiGeorge syndrome without having the typical deletion. Closer examination showed that some of these individuals had SNV in the TBX1 gene. Which of the following SNVS would be most likely to create a similar phenotype to the deletion?
A. A variant in the promoter region of TBX1 that increases its expression
B. A variant in the intronic region of TBX1 that does not affect splicing. X
C. A nonsense variant near the 5' end of the TBX1 gene.
D. A silent variant near the 5' end of the TBX1 gene.

Answers

Answer:

D. A silent variant near the 5' end of the TBX1 gene.

Explanation:

TBX1 gene is wild type human being. It gives instructions for making protein called T-box 1. It plays an important role in tissue formation and organs during embryonic development.

Afferont neurons
a.transmit sensory input to the CNS
b.are multipolar neurons
c.have many dendrites and a single long axon
d.are found only within the brain and spinal cord

Answers

Answer:

a.transmit sensory input to the CNS

Explanation:

Afferent neurons will take input from your muscles, skin etc. and send it to your CNS (usually via spinal nerves).

In a certain population, the allele causing sickle cell anemia has a frequency of 0.2. If the population is in genetic equilibrium for this allele, what fraction of the population would be heterozygous for this gene

Answers

Answer:  

32% population would be heterozygous for this gene.

Explanation:

Due to technical problems, you will find the complete explanation in the attached files

The genetic code is defined degenerate or even redundant because:
A. the same codon codes for different amino acids
B. an amino acid can be encoded by several codons
C is different in all organisms, except in monozygotic twins
D. the sequence of codons is not separated by intervals, but is continuous
E. the structure of the genes is constantly mutating

Answers

Answer:

B. an amino acid can be encoded by several codons

Explanation:

The genetic code refers to the set of rules that govern how the four nitrogenous bases (A,U,G,C) is arranged to form amino acids. The genetic code is a collection of all the CODONS formed. There are different characteristics of the genetic code and one of them is its REDUNDANCY.

Since there are 4 nitrogenous bases combined in three's to form a codon i.e. 4³, there are 64 possible codons that could form 20 maximum amino acids. This means that there are more codons in relation to amino acids. Hence, more than one codon can encode an amino acid, and this is referred to as REDUNDANCY of the genetic code.

For example, LEUCINE amino acid is encoded by 6 codons as follows: UUA, UUG, CUU, CUC, CUA, CUG.

Which actions could be categorized in the “aerobic” section of the Venn diagram?

Answers

Answer:

Starts process with a glucose molecule (Obtaining ATP begins with a breakdown of a glucose molecule (hence the name of glycose), and this is in common with the anaerobic process since this step does not require oxygen.)

Explanation:

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Answer:

If your doing the test on edgen then the answers are A.)consists of three stages, B.)yields 36 ATP molecules and, E.)starts process with a glucose molecule

Explanation:

I really hope his helps :) !!!!!!!!!!!!

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Most streams result from _____.
a. altitude
b. melted snow
c. oceans
d. rivers

Answers

Answer:

....b........ melted snow

C because I just took a test like that

which property has not been observed for membrane proteins being degraded for energy during biological pathways

Answers

Answer:

energy storage

Explanation:

Membrane proteins are proteins that are either form part of or interact with cell membranes. Based on their interactions, membrane proteins can be categorized into integral proteins, which are a permanent part of a cell membrane, and peripheral proteins, which adhere temporarily to the cell membrane. Membrane proteins play many critical functions, for example, 1-they are involved in the passive and active transport of substances across cell membranes, 2-act as enzymes that catalyze chemical reactions, 3-act as receptors that bind specific molecules (such as hormones or neurotransmitters) in order to activate signaling cascades, 4-mediate communication between cells, 5-provide a mechanical link between the extracellular matrix and the cytoskeleton, etc.

Describe how table salt dissolves in water in 300 words.​

Answers

Answer:

salt disloves in 300 words

Answer:

Salt (sodium chloride) is made from positive sodium ions bonded to negative chloride ions. Water can dissolve salt because the positive part of water molecules attracts the negative chloride ions and the negative part of water molecules attracts the positive sodium ions.

Explanation:

When sodium chloride is dissolved in water, the polar water molecules are able to work their way in between the individual ions in the lattice. The water molecules surround the negative chloride ions and positive sodium ions and pull them away into the solution. This process is called dissociation.

3. A bacterial isolate from a urine specimen was grown in culture, Gram stained, and then tested for its ability to ferment sugars and hydrolyze various subtrates. What approach to bacterial identification is this an example of

Answers

Answer:

Phenotypic approach for bacterial identification

Explanation:

Bacterial identification can be done by conventional methods, which are based on phenotypical characteristics. These methods are much affordable and reasonable.

Phenotypical identification is based on bacteria´s observable characteristics, such as their morphology, development, and biochemical/metabolic properties.

It is important to consider that these methods do not provide absolute certainty. They can only indicate the genera or species to which the bacteria under study may belong.

Some primary evidence is usually used for fast bacteria identification:

Gram staining, morphology, growth at different media or different incubation atmospheres, glucose fermentation, spores production, motion, aerobiosis/anaerobiosis, among others.  

Knowing that the bacteria in the exposed example was isolated and grown in culture, then Gram-stained and tested for biochemical reaction, we can assume that the approach for its identification is phenotypic.  

¿Qué nombres reciben los tejidos que dan
origen a los tejidos adultos de las plantas?
a. Tejidos diferenciados
b. Tejidos indiferenciados (meristemos)
c. Tejidos vegetales

Answers

Answer:

D

Explanation:

explain what it means to view something from a frae of reference. provide an example that illustrate your explanation.

Answers

Answer:

ex. where you are standing now

a perspective that one uses to determine if an object is moving.

Explanation:

in physics, a frame of reference, or reference frame, is a perspective that one uses to determine if an object is moving. ... For example, when you see a ball roll down a street, you can tell the ball is moving because the frame of reference is the streets, whatever may be on the side of the roads, or the Earth.

wikipedia

Which of the cardiac cell characteristics describes the
ability to initiate an electrical impulse?

Answers

Answer:

The correct answer is: automaticity.

Explanation:

Cardiac muscle has several properties. These properties are: automaticity (given by the pacemaker cells), conductivity (meaning that each cardiac cell can transmit the electrical impulse to the next cardiac cells), contractility (like other types of muscles, cardiac muscle cells can contract), and irritability (each cell can contract on its own without the external stimuli).

Cardiac pacemaker cells are the ones with the capacity to initiate the electrical impulse by creating rhythmic impulses called action potentials, and thus directly regulating heart rate.

Pacemaker cells are located in the sinoatrial (SA) node, in the upper portion of the right atrial wall. In these cells, depolarization of the cardiac muscle begins, and the electrical impulse generated by it is transmitted to the atrioventricular (AV) node, the His bundle and then the Purkinje fibers - this order of events is necessary for the correct contraction of the heart to occur. All of these structures are part of the Conduction System of the heart.

Write an experiment to show that sunlight is necessary for photosynthesis.

Answers

Answer:

Explanationwe have two or three plants, they both get the same water every day they both get the same amount of soil and fertilizer, one is without sunlight and one is with, after a 2 weeks our results will be found

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When a neuron is stimulated and sodium channels open, the process of has begun. Structures of the nervous system surrounding, but not part of the central nervous system are part of the . Two consecutive neurons communicate at a , where they physically come together. are a group of natural chemicals that reduce the perception of pain. Supporting cells of the nervous system are collectively called . When potassium channels have been open long enough to go below resting membrane potential, has occurred.

Answers

Answer:

- When a neuron is stimulated and sodium channels open, the process of depolarization has begun.  

- Structures of the nervous system surrounding, but not part of the central nervous system are part of the peripheral nervous system

- Two consecutive neurons communicate at a synapse, where they physically come together.  

- Endorphins are a group of natural chemicals that reduce the perception of pain.  

- Supporting cells of the nervous system are collectively called neuroglia

- When potassium channels have been open long enough to go below resting membrane potential, hyperpolarization has occurred.

Explanation:

Neurons undergo depolarization in response to diverse stimuli (e.g., heat, light, electrical, chemical, etc). The depolarization occurs when sodium (Na+) ions pass through specific channels  (i.e., open voltage-gated Na+ channels) into a neuron, which causes an increase in the positivity of membrane potential. On the other hand, hyperpolarization occurs when potassium (K+) channels remain open and Na+ channels reset, thereby producing an increase in negativity of membrane potential. The peripheral nervous system (PNS) is composed of the cranial nerves, spinal nerves, peripheral nerves, and neuromuscular junctions, which connect the Central nervous system (CNS) to the organs, limbs, and skin. Endorphins (e.g., serotonin) are polypeptides secreted by the pituitary gland and CNS to relieve stress and pain. Neuroglia refers to a class of neural cells that have ectodermal (e.g., astroglia, peripheral glial cells) or mesodermal (e.g., microglia) origins. Neuroglia cells are involved in diverse roles, including, among others, the formation of the blood-brain barrier, homeostatic support, provision of nutrients for neurons, structural support to nerve cells, etc.

What is silk thread?

Answers

Silk worms are an invasive species in the UK. They cover trees and kill them….. silk comes out of their butt and we call it silk thread. Silk thread is silk spun into thread, or silk worm pooo pooooooo

Which of the following sentences uses commas correctly? Carol was the last person out of the house wasn't, she? Carol was the last person, out of the house wasn't she? Carol was the last person out of the house, wasn't she? Carol, was the last person out of the house wasn't she?

Answers

Answer:

The third sentence......................

Explanation:

The correct sentence is Carol was the last person out of the house, wasn't she?

Why is a comma important?

Commas help your reader figure out which words go together in a sentence and which parts of your sentences are most important. Using commas incorrectly may confuse the reader, signal ignorance of writing rules, or indicate carelessness.

What are the Rules of commas?

Comma Rules

Use a comma after an introductory phrase or clause. Use commas before and after a parenthetical phrase or clause. Use a comma to separate two independent clauses linked by a coordinating conjunction (and, but, for, nor or, so, yet) Use a comma to separate items in a series.

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A particular cross gives a modified dihybrid ratio of 9:7. What phenotypic ratio would you expect in a testcross of the fully heterozygous F1 crossed with the fully recessive type

Answers

Answer:

3:1

Explanation:

Due to technical problems, you will find the complete explanation in the attached files.

an ion is formed when an atom

Answers

the basic unit of a chemical element.

Answer:

The basic unit of the chemical elements

Solve the equation of mava=mbvb max5.0ml=5.2mlx0.10m

Answers

Answer:

0.104M

Explanation:

The following equation is given in this question:

mava=mbvb

Where;

ma = molarity of acid (M)

mb = molarity of base (M)

va = volume of acid (ml)

vb = volume of base (ml)

According to this inputted values;

max5.0ml=5.2mlx0.10m

ma = unknown molarity of acid

mb = 0.10M

va = 5.0ml

vb = 5.2ml

Hence, ma x 5.0ml = 5.2ml x 0.10m

5ma = 0.52

ma = 0.52 ÷ 5

ma = 0.104M

Unlike other plants, trees are plants living for several years thus they are

A. Annual

B.shade

C.perennial

D. Fence

Answers

c. perennial

hope this helps!
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and ends at (240,250). There is a blue downward sloping line that starts at (70,250) and ends at (240,150).) What sales price should you select to meet the equilibrium price for the lawn mower? sets A and B have 3 and 6 elements respectively. what can be the minimum number of elements in AUB Who would most likely have disagreed with the bishop'spoint of view?a French aristocrata bishop who was not a member of the royal courta member of the British Parliamentan absolute monarch from Spain or Russia An effect of the Great Peasants Revolt was that I need it ASAP!!! Please ________ is a style of coping with stress that features a positive outlook, a sense of commitment, and a sense of contro Express each of the following quadratic functions in the form of f(x) = a (x - h)+ k.Then,state the minimum or maximum value,axis of symmetry and minimum or maximum point. (a) f(x) = -2x + 7x + 4.Pls help me ans this question,its urgent!!I'll mark u as the brainliest! What does a MRTS = mean? It means that if the input on the horizontal axis is increased by one unit, then the input on the vertical axis increases decreases by units and output will increase decrease not change . Which one of the following molecule is planer? a. NF3 c. PH3 b. BH3 d. NCl3 How would I draw the reflection over the line y=2x+5? There are 103 pounds of wood pieces in a bag. Each wood piece weighs 53 pounds. How many wood pieces are there in the bag? In a triangle ABC, a=4 cm, b=3 cm and angleC=30, find the area of triangle ABC.a. 6b. 1.5 c. 3d. 3 root 3 1. (small) The company developed __________ laptop computer in the world. Which of the following means "make"? A. -lan B. -or C. -fy D. -ent If 53 cos = in the first quadrant, what does cot equal? Cmo era la situacin de la mujer durante la colonia which type of hormone diffuses across the plasma membrane and binds to receptors in the cytoplasm module 16.4c where can we find most of the gases ? to the left or right section ? explain . Jasmine is going out for dinner with friends. Which options are the healthiest for each part of her meal?The healthiest entre choice is .The healthiest side dish choice is .The healthiest dessert choice is .The healthiest beverage choice is . Choices:One-sixth cupsFive-sixths cups1 and two-thirds cups1 and 5 / 6 cups