Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?
A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes

Answers

Answer 1

Answer:

C) proteins with gain-of-function mutations

Explanation:

Gain-of-function mutations: In biology, the term "gain-of-function mutation" is described as one of the different types of mutation in which the altered or changed "gene product" consists of an entirely new pattern or molecular function associated with gene expression. However, the "gene-of-function mutations" are being always considered as "Semidominant or Dominant".

In the question above, the correct answer is option C.


Related Questions

ABO blood type is examined in a Taiwanese population, and allele frequencies are determined. In the population,
f (IA) = 0.30,
f(IB) = 0.15, and
f (i) = 0.55.
What are the frequencies of the various genotypes and various phenotypes in this population? Assume Hardy-Weinberg equilibrium.

Answers

Answer and Explanation:

Due to technical problems, you will find the answer and explanation in the attached file.

Which sentence about protist is accurate

Answers

Answer:

there are no sentences

Explanation:

Which location is least likely to experience a volcanic eruption? Α. an island hot spot, such as the island of Hawaii B. Hamilton County on the plains of central Texas с. a convergent boundary, as in the Ring of Fire D a volcanic island arc, such as the Aleutian Arc in Alaska

Answers

Answer:

i think that the answer is B. Hamilton County on the plains of central Texas i took the test

Explanation:

Hamilton County on the plains of central Texas is least likely to experience a volcanic eruption. Therefore, option (B) is correct.

What are volcanoes?

Molten rock and gases stored under the surface erupt through a volcano, generating a hill or mountain.

Active, inactive, or extinct volcanoes. Active volcanoes are likely to erupt again. Dormant volcanoes may erupt again. Extinct volcanoes won't erupt.Magma collects inside active volcanoes. The magma chamber's pressure forces it through rock channels and onto the planet's surface.

Volcanic eruptions can be violent or slow-moving. Volcanoes erupt through vents on the sides or a primary entrance at the top. The volcano's morphology depends on eruption rate and magma chemistry. Land and sea volcanoes exist. As lava cools and hardens, underwater volcanoes build mountains and ranges. When volcanoes rise above the ocean, they create islands.

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all of the following are examples of organic matter soil except

Answers

This question is incomplete; here is the complete question:

All of the following are examples of organic matter soil except

A. Decaying plants

B. Bacteria

C. Fungi

D. Water

The answer to this question is D. Water

Explanation:

Organic matter derives from living beings, due to this, organic matter is considered as a biological product. In this context, materials such as decaying plants are organic matter because they derive from living organisms and contain biological molecules (most contain carbon). This category does not apply to water, which is composed of hydrogen and oxygen and does not derive from living beings. Thus, the one that is not organic matter is water.

Answer:

D. Water

Hope this Helps!! :))

Which of the following is a testable scientific question

Answers

Where are the questions so i can answer them?

Answer: Just took the test: Its "How does the age of city affect the number of trees in the city? "

How does the movement of particles of matter change when temperature increases?
Decreases
Increases
Increases then decreases
Does not change

Answers

Answer:

Increases

Explanation:

The movement of particles of the matter increases with the increase in temperature.

The particles gain kinetic energy with increasing temperature and move in faster rate.

For example: When we blow a balloon with our mouth, we increases the temperature inside the balloon, the particles in the balloon gain kinetic energy that leads to the faster movement of gas particles in the balloon and they collide with each other and surface of balloon, after a peak the balloon get burst because of high kinetic energy and high collision.

Hence, the correct answer is "increases".

What complications might arise from genetic screens targeting an organ that differentiates late in development?

Answers

Answer:

No sign of testicular development in boys and breast development in girls.

Explanation:

Complications like no sign of testicular development in boys and breast development in girls occurs if an organ develop very late. There are many causes of this type of complications such as long term illness, eating improper food and disorder of sexual development. Sometime these complications  also occurs due to genetically. These complications should be treated well with medication and use of nutritious food. These medicines increases the performance of sex hormones in order to initiate puberty.

Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome. If a researcher moves the repressor gene (lacI), along with its promoter, to a position at some several thousand base pairs away from its normal position, which of the following results would be expected?
A) The repressor will no longer bind to the operator.
B) The repressor will no longer bind to the inducer.
C) The lac operon will be expressed continuously.
D) The lac operon will function normally.

Answers

Answer:

D) The lac operon will function normally.

Explanation:

The promoter area can be described as the area that causes the transcription to initiate for a particular gene. Promoters may be near the genes from which they initiate transcription or they may display multiple scenes upstream. The lock operon works normally because the promoter area can still enable transcription on many base pairs. Detects repression promoter and works normally.so correct option is D) The lac operon will function normally.

If a researcher moved the repressor gene of lac I, along with its promoter; the lac operon will function normally. Option D is correct.

Promotor:

It is the genetic sequence that is recognized by the RNA polymerase to start the transcription.

Here, researcher moved the repressor gene of lac I , along with its promoter.

Therefore, transcription starts, it will express the repressor gene also because repressor gene was moved with promotor.

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A paleontologist finds a relatively complete skeleton but isn’t sure if it is an ape fossil or a hominid fossil. Which of the following features would NOT help distinguish between the two choices?
a. position of the opening in the skull for the spinal cord
b. design of the pelvis
c. relative length of the hind limbs
d. position of the eyes

Answers

c. relative length of the hind limbs. Overall fossilized apes and hominids are 90+% similar in the past 3.5 million years since Australopithecus afarensis but this one aspect of upper vs. lower limbs is the greatest difference. Hope this helps!

Alexei Romanov suffered from hemophilia, a condition that (1 point)
causes the body to produce too many blood cells due to the body's inability to form fibrin proteins.
o prevents blood from clotting normally due to the body's inability to form fibrin proteins.
O causes the body to produce abnormally shaped red blood cells due to the body's inability to form fibrin proteins.
o prevents the body from absorbing vitamin B12 due to the body's inability to form fibrin proteins.

Answers

Answer:

prevents blood from clotting normally due to the body's inability to form fibrin proteins.

Explanation:

Haemophilia is a genetic disorder which could be inherited and it is characterized by constant bleeding and loss of blood when injuries occur. This is as a result of the inability of the body to form fibril proteins. The fibril proteins are responsible for the production of platelets . The platelets are responsible for the clotting of blood.

This validates haemophilia being a disorder which prevent blood from clotting normally due to the body's inability to form fibrin proteins.

For those who need more answers

1. Adenine

2. Prevents blood from clotting normally due to the bodys inability to form fibrin proteins

3. TCA

4. DNA has the sugars deoxyribose, while RNA has the sugar ribose

5. tRNA carries amino acids to the ribosome and helps form proteins

A response to an unconditioned stimulus that occurs naturally without learning is known as a(n) __________ response.
A. neutral
B. conditioned
C. reconditioned
D. unconditioned

Answers

Answer:

it is going o be B. conditioned

Answer:

D

Explanation:

edge

When the body cells are hypotonic to the blood plasma, water will move from intracellular fluid to extracellular fluid.
A. True
B. False

Answers

Answer:

True

Explanation:

I need help with this

Answers

Answer:

I know the answer

Explanation:

Yes

Yes

Yes

A class is debating pros and cons of using sea walls to reduce beach erosion. What is the best way for them inform their
decision-making?

They should each write an opinion paragraph to send to the local paper.

They should hold the debate on stage, so that they can be judged.

They should watch movies about beaches.

They should research wave action and collect data about erosion in the area.

Answers

Answer:

They should research wave action and collect data about erosion in the area.

Explanation:

everyone has their own opinion, and movies aren't gonna make the cut, and no one wants to see a debate in school, so they should research first to get the info they need

QUICKLY! The chemical reaction equation of photosyntesis is shown here: What information is not given in this equation. It does not show if the reaction is reversible. It does not show the reactants needed for the reaction. It does not show that photosynthesis consists of many separate steps. It does not show the number of molecules required to produce glucose.

Answers

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

Photosynthesis is a unique process carried out by the cells of autotrophic organisms. It is the process whereby they synthesize their own food in form of sugars (glucose) in the presence of sunlight. Ideally, the photosynthetic process makes use of carbon dioxide (C02) and water (H20) in the presence of light energy (from sun) to produce glucose sugar (C6H12O6) and oxygen (02). The general photosynthetic equation is as follows:

6CO2 + 6H20 + light → C6H12O6 + 6O2

However, the process is not as simple as portrayed as it involves many separate steps that collectively forms the photosynthetic product (glucose). Photosynthesis occurs in two major stages namely: light stage and light independent stage, which in turn consists of series of reactions that forms the products.

Therefore, the equation attached to this question describes photosynthesis but It does not show that photosynthesis consists of many separate steps.

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

why are g protein important for drug discovery?

Answers

Answer:

G protein - coupled  receptors(GPCRs)n belong to a large family of signaling proteins that  mediate cellular  reponses to most hormones ,metabolites,cytokines and neuotransmitters and therefore serve as fritful targets for DRUGS DISCOVERYS.

Explanation: histamine(HRH1),serotonin dopamine,opiod and adrenergic receptors.

I HOPE IT'S HELPS YOU TO UNDERSTAND

A.While the traits studied in Exercise 1 were hypothetical genetic traits, what type of genetic traits do you think are important to study and predict

Answers

Answer:

Genetic disturbances harmful to the organism are genetic characteristics that must be studied and predicted.

Explanation:

Genetic disorders that harm an organism such as sickle cell anemia, hemophilia, Turner syndrome, among others, are important to be studied and predicted, because it will provide better maintenance of that organism. Allowing people who inherit these characteristics to have more efficient treatments and a better life, since the prediction of these characteristics allows the family to establish better adapapitativo methods, that will make the life of this individual easier and with more quality.

Why are G proteins known as guanine nucleotide-binding protein?

Answers

Answer:

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. ... G proteins belong to the larger group of enzymes called GTPases.

If a person had not drunk any water for 8 hours before collecting a sample, would you expect his/her urine to have a high or low specific gravity? Why?

Answers

Answer:

The person’s urine will have a high specific gravity

Explanation:

A high specific gravity is characterized by an increased concentration of solutes in the urine of am individual. A low specific gravity is characterized by a low or decreased concentration of the solutes.This is usually due to dehydration as a result of environmental conditions or tedious physical activities.

This explains why a person who had not drank any water for 8 hours and is dehydrated before collecting a sample is thought to have a urine with a high specific gravity

Which conclusion can be drawn from the experimental observation that a single strand of DNA contains 2100 dA residues and 1800 dT residues?

Answers

a. There must have been some loss of material in the extraction because the number of dA and dT residues must be the same.

b. This is a palindromic sequence.

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

d. This must be prokaryotic DNA

e. None of these

Answer:

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

in the krebs cycle,

a. pyruvate is broken down into Co2 molecules
b. glucose is broken down into NADH and CO2
c. Co2 is concerted in pyruvate and O2
d. NADH and CO2 are converted into ATP

Answers

Answer:

a. pyruvate is broken down into Co2 molecules

Explanation:

Krebs cycle is also known as Citric Acid Cycle, in which pyruvate formed during the glycolytic is broken down into Carbon Dioxide (CO2) and Water (H2O).

Each pyruvate molecule is broken down into carbon atom which releases carbon dioxide.

Hence, the correct answer is "a. pyruvate is broken down into Co2 molecules".

This category of plants does not have vascular tissue or seeds. Question 3 options: Angiosperms Gymnosperms Ferns Mosses

Answers

Answer:

Mosses

Explanation:

Mosses are the category of plants that does not have vascular tissue or seeds while angiosperm, gymnosperms, and ferns have vascular tissues and seeds.

Due to absence of vascular bundles or veins, the mosses also lack stems, true roots, and leaves. some of the examples of mosses are: liverworts, hornworts, and Ricceia natans etcetera.

Hence, the correct answer is "Mosses".

Answer:

Mosses

Explanation:

Mosses are the category of plants that do not have vascular tissue or seeds. Ferns do not have seeds, but do have vascular tissues. Angiosperms and gymnosperms have vascular tissue and seeds.

A mutation that hides the effect of another mutation at a site that is distinct from the site of the original mutation, but with in the same gene. This mutation is best described as a

Answers

Answer:

The correct answer is intragenic suppressor mutation.

Explanation:

A suppressor mutation partially or completely converses the effects of a different mutation. A suppressor mutation is of two kinds, that is, an intragenic suppressor and an intergenic suppressor. An intragenic suppressor converses the influence of a mutation at a distinct site in a similar gene.  

On the other hand, an intergenic suppressor converses the influence of a mutation at a distinct locus of the gene. It is the intragenic suppressor mutation, which takes place in a similar gene where the occurrence of the first mutation had taken place. Therefore, the mutation, which hides the influence of another mutation at a location, which is different from the location of the original mutation, but taking place in a similar gene can be illustrated as the intragenic suppressor mutation.  

Choose only one correct option. Explanation needed.

Answers

Answer: D

only green plants

Answer:

[tex]\large \boxed{\mathrm{D. \ Photosynthesis}}[/tex]

Explanation:

Photosynthesis is a characteristic present in plants. Photosynthesis is a process where plants transform light energy into chemical energy. Reproduction, respiration, and excretion are all characteristics of living organisms.


is the basic unit of structure and function of living things.

Answers

Answer:

cells

Explanation:

is the basic unit of life :)

The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane

Answers

Answer:

The question is incomplete, below is the completed question:

The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane ?

a. Diffusion, or passive transport, occurs when molecules diffuse from a lower concentration to a higher concentration.

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

c. The lipid bilayer opens up and allows the ions or molecules to enter the cell, then closes.

d. Active transport occurs when molecules diffuse from a higher concentration to a lower concentration.

Answer:

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

Explanation:

Transport through cell membranes can be broadly classified as active transport or passive transport.

Active transport requires energy in the form of ATP for the transportation of substances across the cell membrane.

Option b correctly describes facilitated diffusion, which is a passive-mediated diffusion process, where channels in the cell membrane mainly composed of proteins called transmembrane integral proteins, allow for the movement of certain molecules (mostly polar/hydrophilic) molecules that will not otherwise be transported through simple diffusion because of the hydrophobic nature of the cell membrane.

The other options are wrong because:

a. diffusion or simple transport involves the movement of substances from regions of higher to a lower concentration not lower to higher as suggested here.

c. The lipid bi-layer does not allow ions or hydrophilic molecules because it is hydrophobic in nature, and it is not a channel, so it does not open and closes

d. In active transport, transfer of molecules is from regions of lower to higher concentration and not higher to lower concentration as suggested here.

the origin of a muscle is generally

Answers

explain the  question more

Answer: The stable and proximal attachment

Explanation:

____________ a regulatory protein that may bind DNA to inhibit transcription. ____________ a DNA sequence that binds a regulatory protein. ____________a DNA sequence that binds RNA polymerase and regulates transcription. ____________a compound that interacts with another protein or compound to form an active repressor ____________a compound that induces or activates transcription, such as lactose.a. Repressorb. Operator c. Promoterd. Corepressore. Inducer

Answers

Answer:

A repressor is a regulatory protein that may bind DNA to inhibit transcription. An operator is a DNA sequence that binds a regulatory protein. A promoter is a DNA sequence that binds RNA polymerase and regulates transcription. A corepressor is a compound that interacts with another protein or compound to form an active repressor. An inducer is a compound that induces or activates transcription, such as lactose.

Explanation:

Repressor proteins bind to DNA and RNA to suppress target gene expression. A DNA repressor blocks transcription by inhibiting the attachment of RNA polymerase to the promoter sequence, while an RNA repressor bind to the mRNA to block translation of the protein. An operator is a DNA sequence required for the attachment of transcription factors. The genes that are transcribed by the binding of a transcription factor to an operator sequence are collectively referred to as an operon. Operons are generally found in prokaryotes but they also can be found in some eukaryotes including Caenorhabditis elegans and Drosophila melanogaster. An inducer is a molecule that activates gene transcription either by binding to repressors/corepressors (thereby inactivating their functions) or by binding activators. For example, the allolactose act as an inducer of the lac operon.

Which of the following best explains the potential health problems associated with endocrine disruptors? A) Endocrine disruptors are the only available pesticides,hence they are used widely. B) Endocrine disruptors mimic hormones that regulate critical biological processes. C) Endocrine disruptors do not biodegrade, remaining toxic years after their release. D) There are no major health problems associated with exposure to endocrine disruptors. E) Endocrine disruptors encompass a wide array of toxic pesticides.

Answers

B) Endocrine disruptors mimic hormones that regulate critical biological processes.

Endocrine disruptors, at times moreover called as hormonally unique trained professionals, endocrine disturbing engineered substances, or endocrine upsetting blends are manufactured substances that can interfere with endocrine structures. These aggravations can cause threatening developments, birth flees, and other developmental issues.

The potential health problems associated with endocrine disruptors is that Endocrine disruptors mimic hormones that regulate critical biological processes.

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Answer:

It's A.) Endocrine disruptors mimic hormones that regulate critical biological processes.

Explanation:

Quizlet gave me the answer

(06.03 LC) Which of the following is an example of how HIV can be transmitted from one person to another? Contact between infected blood and a mucus membrane Contact between infected saliva and an open wound Contact between infected blood and skin Contact between infected saliva and lining of mouth

Answers

Answer:

i believe the answer is contact between a infected blood and a mucus membrane

Explanation:

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Russia .......... earlier this week that it ......... all its troops out of Georgea) had announced /pulled b) announces /would have pulled c) announced /had pulledd) announced / has pulled e) has announced /was pulling Nina is training for a marathon. She can run 4 1/2 kilometers in 1/3 of an hour. At this pace, how many kilometers can Nina run in 1 hour? Trevor Company discloses supplementary operating segment information for its three reportable segments. Data for 20X8 are available as follows: Segment A Segment B Segment CSales $500,000 $300,000 $200,000Traceable operating expenses 250,000 120,000 90,000Allocable costs for the year was $180,000. Allocable costs are assigned based on the ratio of a segment's income before allocable costs to total income before allocable costs. The 20X8 operating profit for Segment B was:_______.A) $180,000. B) $120,000. C) $126,000.D) $110,000. find m how did the ruling philosophies of joseph stalin and benito mussolini differ? A car enters a turnpike 22 miles north of a town. The car teavels north at an average speed of 64 miles per hour. How far is the car from the town after 4 hours? Explain how you can use linear function to solve this problem. Then, solve the problem. Consider two parallel plate capacitors. The plates on Capacitor B have half the area as the plates on Capacitor A, and the plates in Capacitor B are separated by twice the separation of the plates of Capacitor A. If Capacitor A has a capacitance of CA-17.8nF, what is the capacitance of Capacitor? . Which state of matter does this image represent? Image of water Solid Liquid Gas Plasma how can i solve this factorial? A 6,2- P6- A 5,3 + P5 How did Great Britain justify levying hefty taxes on the colonies? 4.Suppose you hold a PUT option on Israeli shekels with a strike price of 3.4207s/$. If the spot rate on the final day of the option is 3.4329s/$, how much profit would you make trading $1,000,000? Should you do it? You add 500 mL of water at 10C to 100 mL of water at 70C. What is themost likely final temperature of the mixture?O A. 80COB. 10-COC. 20CO D. 60C isted below are amounts (in millions of dollars) collected from parking meters by a security service company and other companies during similar time periods. Do the limited data listed here show evidence of stealing by the security service company's employees? Security Service Company: 1.5 1.7 1.6 1.4 1.7 1.5 1.8 1.4 1.4 1.5 Other Companies: 1.8 1.9 1.6 1.7 1.8 1.9 1.6 1.5 1.7 1.8 Find the coefficient of variation for each of the two samples, then compare the variation. The coefficient of variation for the amount collected by the security service company is nothing%. (Round to one decimal place as needed.) Question 2: Jamie has a jar of coins containing the same number of nickels, dimes and quarters. The total value of the coins in the jar is 13.20. How many nickels does Jamie have? If the lead concentration in water is 1 ppm, then we should be able to recover 1 mg of lead from _____ L of water. Need Assitance*Show Work* As the language changed from Old to Middle to Modern English, many _________ were dropped. Explain the concept of an opportunity cost with an appropriate example The health food store that you manage employs 7 clerks. Individual hourly wages are $8.10, $8.25, $8.45, $8.75, $9.00, $9.25, and $10.50. If each employee has 2 weeks unpaid vacation and works 8 hours a day , 5 days per week and is paid for all holidays , what the total annual payroll for the clerks ? is 1 whole 1 by 3 considered as an integer??