Pharmacokinetics and pharmacodynamics of a new formulation of an investigational drug most likely refers to which clinical phase of a study in humans?

Answers

Answer 1

Answer:

The correct answer is - Phase I.

Explanation:

Clinical phase are group of stages in which scientists or researchers  conduct various experiments with a health intervention to get enough evidence for a process to use as a medical treatment. Clinical research is conducted on medical devices, drug candidates, and vaccine candidates.

In the phase I, in this phase intervention takes place in human subjects. These subject usually observed until several half-lives of the drug have passed. This phase is designed to assess the tolerability, pharmacokinetics, safety (pharmacovigilance), and pharmacodynamics of a drug


Related Questions

What is the main transformation that occurs during glycolysis?
Glycolysis produces ATP and pyruvate by oxidizing water.
Glycolysis produces ATP and pyruvate by oxidizing glucose and NAD+.
Glycolysis produces pyruvate, ATP, and NADH by oxidizing glucose.
Glycolysis produces CO2, ATP, and pyruvate by reducing glucose.

Answers

Answer:

Glycolysis produces pyruvate, ATP, and NADH by oxidizing glucose.

Explanation:

This is the main transformation that occurs during glycolysis. Hence, this statement is correct answer.

Glycolysis produces pyruvate, ATP, and NADH by oxidizing glucose.

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what is photo synthesis​

Answers

Answer:

Explanation:

Photosynthesis is the process of producing Glucose from CO2 and Water. The chemical reaction requires sunlight.

6H2O + 6CO2 ===> C6H12O6 + 6O2

If you are interested in the Environment, you should notice that plants take in CO2 and give away O2, the exact opposite of what animals and humans do. We should be extra careful about how we treat forests -- they produce what we need.

One of your homework questions is reproduced below.
All six answers were correct. Can you
think of two more conceivable answers to the question below?
Many promoters are regulated by proteins that bind to adjacent DNA sequences. Which of the following is correct?
A. Some transcriptional regulators stimulate transcription and do so only when binding a low molecular weight ligand.
B. Some transcriptional regulators stimulate transcription and do so only when NOT binding a low molecular weight ligand.
C. Some transcriptional regulators inhibit transcription and do so only when binding a low molecular weight ligand.
D. Some transcriptional regulators inhibit transcription and do so only when NOT binding a low molecular weight ligand.
E. Some transcriptional regulators stimulate transcription and do so only when phosphorylated.
F. Some transcriptional regulators repress transcription and do so only when phosphorylated.

It’s not multiple choice, I need help coming up with two more answers that are true

Answers

Answer:

Phosphorylation activation:

1- p53 (transcriptional activator)

2- CDK8-cyclin C (transcriptional inhibitor)

Explanation:

Phosphorylation is a well-studied post-translational modification mediated by a protein called 'kinases' which phosphorylates specific protein substrates. This post-translational modification (phosphorylation) acts as a reversible switch capable of modulating protein function. Phosphorylation at specific amino acid residues (e.g., tyrosine, serine) controls protein function by triggering conformational changes in the phosphorylated protein. For example, P53 is a transcription activator activated by phosphorylation at multiple sites in its N-terminal region. P53 activates transcription of different genes by modulating protein-protein interactions with different substrates (e.g., MDM-2, CBP/p300, TFII). On the other hand, cyclins are proteins that have no enzymatic activity but are able to activate cyclin-dependent kinases (CDKs) by binding to them. CDK8-cyclin C (SRB10-SRB11) is a negative regulator of transcription that is able to inhibit transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II (Pol II) before the formation of the preinitiation transcriptional complex.

turnips are root vegetables. turnips have been selectively bred from a wild plant called field mustard. field mustard plants do not have big, round roots like turnips. explain how turnips have been selectively bred from field mustard.

can anyone help me out? thx

Answers

the turnips have a model called Turnip's model that's why the turnips have been selectivity breed from field mustard.

Turnip is a type of root vegetables that belongs to the mustard family.

Turnips are ready to harvest 40 to 55 days after planting. If harvesting the leaves, they are ready when they reach four to six inches in height. If only harvesting the leaves, cut them from the plant when they reach the desired size, leaving one inch of leaves above the crown of the plant. More leaves will grow in their place.

Learn more about vegetables:

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what are chloro-fluoro carbons ??
explain !!! ​

Answers

Answer:

Chlorofluorocarbons are fully or partly halogenated paraffin hydrocarbons that contain only carbon, hydrogen, chlorine, and fluorine, produced as volatile derivative of methane, ethane, and propane.

Explanation:

elephantiasis is transmitted by :
a. fruit fly b. may fly
c. culex d. Anopheles

Answers

Answer:

The correct answer is - d. Anopheles.

Explanation:

Culex, a species off mosquitoes known as the vector for many viral and parasitic diseases such as elephantiasis, that spread the disease and to one person to other.

In America culex is the main vector for Lymphatic filariasis or elephantiasis that is caused by a parasite. However in Africa Anopheles is the main mosquitoes causes Lymphatic filariasis or elephantiasis in people of the area.

Which of the following characteristics must an object possess in order to be considered alive? Select all that apply

Answers

Explanation:

responds to the environment.

It grows and develops.

It produces offspring.

It maintains homeostasis.

It has complex chemistry.

It consists of cells.

flexbooks dot ck12 dot org 

Photosynthesis happens in the?

Answers

Photosynthesis happens in the plants which have chlorophyll.

Photosynthesis occurs in the chloroplast, an organelle specific to plant cells.

The picture below shows the devils Millhopper sinkhole in Florida.

The sinkhole was formed when:

A. River water eroded the soil
B. An underground cavern collapsed
C. A hurricane flooded low lying areas
D. Plant roots caused mechanical weathering of rocks

Answers

Sinkholes form when limestone is slowly dissolved by acidic groundwater over geologic time. ... This process of dissolution can create large cavities in limestone. A sinkhole forms when the roof of a cavity in the limestone collapses and creates a depression at the land surface.

Answer:

B

Explanation:

Mycoplasmas which belong to Firmicutes are pleomorphic because: (2 pts) they have no cell walls they are low G C content Gram-positive bacteria they exhibit snapping division they reproduce asexually they produce endospores

Answers

Answer:

they have no cell walls.

Explanation:

Mycoplasmas that belong to Firmicutes are considered as pleomorphic because they have no cell walls in their structure. Mycoplasmas have the following characteristics i.e. the smallest mycoplasmas are 125–250 nm in size, they are highly pleomorphic because they lack a rigid cell wall and instead of cell wall they are bounded by a triple-layered “unit membrane” that contains a sterol in its structure.

n the sliding filament model of muscle contraction, the myofilaments slide over each other, resulting in the overlappying of actin and ____________ .

Answers

Answer:

In the sliding filament model of muscle contraction, the myofilaments slide over each other, resulting in the overlappying of actin and myosin.

Explanation:

Sliding filament theory explains the way muscles contract; each sarcomere (functional unit of muscle) contains superimposed thin (actin) and thick (myosin) filaments that are interconnected by cross bridges. According to the theory, the shortening of the length of a sarcomere is produced by the two types of filaments that slide over each other; large intermolecular forces between the myosin head and the crossed bridge cause the head to tilt. Through this power glide, the fine filaments are drawn between the thick filaments of each sarcomere. The contraction is triggered by a stimulating nerve impulse that causes an action potential to spread through the sarcomere.

When you touch an object that is very hot you quickly pull your hand back. What is the correct pathway of nerve impulses for this behavior?
A. Heat receptors in the hand, sensory neurons, brain, motor neurons, hand muscles.
B. Heat receptors in the hand, motor neurons, hand muscles, sensory neurons, brain.
C. Hand muscles, motor neurons, brain, sensory neurons, heat receptors in hand.
D. Brain, sensory neurons, heat receptors in hand, motor neurons, hand muscles.

Answers

A heat receptor>sensory neuron>brain>motor neuron>>hand muscles

Answer:

a

Explanation:

Describe these findings, and explaine their significants; epicanthal fold; pseudostrabismus; ophthalmia neonatorum; Brushfield spots.

Answers

-epicanthic fold: skin across the inner corner of the eye (canthus).
-pseudostrabismus: the appearance of strabismus because of epicanthic fold but is normal for a young child.
-Ophthalmia neonatorum, conjunctivitis of the newborn: purulent discharge caused by a chemical irritant or a bacterial or viral agent from the birth canal.
-brushfield spots: white specks around the edge of the iris.

The data of this lab

the

hypothesis because there was a difference in bird

beak distribution

Answers

Answer:

The answer is "supported and when fruit was removed"

Explanation:

It dated the idea from this laboratory because the distribution of avian beaks differed. If any kind of food available keeps shifting, the frequency of the beak types changes as beaks with beaks is far more suitable for food available. The data in this laboratory confirmed the theory, so because the fruit was removed by birds. These results of this laboratory confirm this idea because the dispersion of pigeons when food was taken was varied.

Answer:        1. supported      2. when fruit was removed

Explanation: :)

When there is plenty of oxygen available in the muscles, the condition is referred to as being:

Answers

Answer:

Aerobic condition.

Explanation:

When there is plenty of oxygen available in the muscles, the condition is referred as aerobic condition because the muscles do respiration in the presence of oxygen. The presence of oxygen to the muscles produced huge amount of ATP which can be used by the body in different activities as compared to anaerobic condition where there is no oxygen and the body produce less ATP for the body.

A solution that is equal in solute concentration to that of the cytoplasm of a cell and causes a cell to neither lose nor gain water by osmosis is a(n)

Answers

Answer:

isotonic solution

Explanation:

The cell membrane is semi-permeable, so it allows to pass through certain solutes. By a process called osmosis, the water molecules move from a compartment of lower concentration of solutes to a compartment with higher concentration.

Therefore, if the concentration of solutes in the outside is higher than the concentration in the cytoplasm (hypertonic solution), the water molecules will move from the interior to the exterior. Conversely, if the cytoplasm is more concentrated than the outside (hypotonic solution), the water molecules will move from the exterior to the interior. If the cytoplasm has the same solute concentration as the outside, the solution of the outside is called isotonic, and no water net flux will be produced.

Why do you think it is functionally important that the bones of the os coxae fuse together rather than remain independent bones

Answers

Answer:

Provides more strength.

Explanation:

It is functionally important that the bones of the os coxae fuse together rather than remain independent bones because the fusion of bones of the os coxae increases their strength and they can perform their function very well. If the fusion of bones of the os coxae did not occur and they remain independently so they can't bear the load of the body and so the function is also adversely affected.

Place the tiles in order so that they describe a population undergoing natural selection
Not all tiles will be used

Answers

Answer:

A new species of hawk that preys on rabbits is introduced to the habitatThe hawks have more success in catching rabbits with white fur because they are easier to see in the habitatThe rabbits´ white fur mutate so their fur is tan or brownThe next generation of rabbits has a higher proportion of individuals with tan and brown fur.

Explanation:

Natural selection is an evolutive force that can act favoring an allele or against it, according to how it affects the fitness of individuals. Natural selection selects beneficial alleles and increases their frequency in the population.

When many organisms in a population sharing the same trait die, it is because they did not have good fitness, so they were not adapted to the environment and its pressures. The alleles coding for that trait were not good for the fitness of the animals, so they do not get to survive.

These individuals die before reproducing, so they could not transfer their genetic charge to the following generation. Eventually, the alleles coding for the trait will decrease in the population, probably near zero. Natural selection is acting against this phenotype. Other alleles will be beneficiated, and their frequency in the population will increase.

This change in alleles frequency is what we call adaptation.

Natural selection results in adaptation, which means the increase of the aptitude phenotype. Aptitude is the contribution of each genotype to the next generation.

In many cases, adaptations can be correlated to environmental factors or selective pressures applied by other organisms or habitats.

Let us remember that a mutation is a change or alteration in DNI sequences that introduce new variants. Many of these are eliminated, but some of them might succeed and be incorporated into each individual. These mutations are the ones that have been selected by natural selection.  

So, in the exposed example, we are focussing on rabbits populations.  

• The selective pressure or modeling environmental factor is predation by the introduced hawk.

• The rabbits´ response to predation is the survival of only those that carry mutations ⇒ tan or brown fur

Natural selection benefits these mutations.  

Tan or brown rabbits survive and increase their fitness.

explain the importance of dimensioning in biology​

Answers

Answer:

Even if you make a drawing to scale, it would be difficult to determine the exact precision that is needed.

It would be time consuming to measure each of the lines to determine measurement.

The basis for modern part dimensioning is the need for interchangeable parts (being able to buy something off the shelf that fits what you already have)

Explanation

When dimensioning, it is good technique to avoid listing the dimension more than once through out the drawing.

If you need to list a dimension more than once, for accuracy or ease of viewing, you must encase the dimension within a set of brackets.

Answer:

The purpose of dimensioning is to provide a clear and complete description of an object. A complete set of dimensions will permit only one interpretation needed to construct the part. Dimensioning should follow these guidelines. Accuracy: correct values must be given.

Which statement best describes how a tree and a mouse get the glucose they need as a source of energy?
O Both a tree and a mouse get glucose indirectly from other living things
A tree makes glucose using the sun's energy, and a mouse gets glucose by eating other living things
Both a tree and a mouse use the sun's energy directly to produce glucose.
Both a tree and a mouse convert ATP into glucose.

Answers

Answer:

The correct answer is

A tree makes glucose using the sun's energy, and a mouse gets glucose by eating other living things.

Explanation:

A tree uses photosynthesis to create energy in the form of glucose. On the other hand, a mouse cannot use the sun's energy to produce glucose through photosynthesis. Therefore the mouse must obtain the glucose by consuming other organisms, such as plants and insects.

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The doubling time of a bacterium was measured at two different temperatures. Which results would be expected of a thermophile

Answers

Answer:

Increase in high temperature.

Explanation:

The population of the thermophile bacteria increase at high temperature as compared to other bacteria at high temperature because thermophile bacteria needs high temperature for growth and survival. Thermophile bacteria that flourish at relatively high temperatures ranging from 41 to 122 °C (106 and 252 °F) so we can conclude that the thermophile bacteria increase in population in the high temperature conditions.

What is one way a mountain might form?
A. Ocean wave force
B. Gravitational pull
C. Glacier movement
D. Volcanic activity
(A p e x)

Answers

Answer:

D.) Volcanic Activity

Explanation:

B is the answer i think

Explain how the structures in the gas exchange system cause inspiration.

Answers

Inspiration is a process in which the lungs receives air from the extrinsic environment.

The process of gas exchanges involves a number of organs and tissues in the body of certain organisms. However, respiratory muscles as part of the body, are used in gas exchange and chiefly used in inspiration.

Inspiration occurs as a result of muscles contraction (for instance, diaphragm and the external inter-coastal muscles) and thus, increasing the volume of the thoracic cavity, which leads to the decrease in the atmospheric pressure in the lungs to supply air (oxygen) into the body.

In other way round, the relaxation of the these muscles brings about expiration i.e., release of gas out of the body.

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Que come un conejo????????

Answers

Answer:

La alimentación de los conejos

80% HENO.

15% HOJAS VEGETALES.

5% PELLETS.

HENO: La dieta debe ser muy rica en fibra por lo tanto un 80% de su alimentación diaria debe ser heno. Podemos diferenciar dos tipos de heno, de gramíneas (mezcla de hierbas secas y flores) o de leguminosas (alfalfa, trébol, soja, etc.).

Explanation:

los conejos comen muchos alimentos, pero principalmente verduras

Zanahorias y lechuga

Which of the following is NOT a way igneous rocks are classified?

Question 2 options:

By their texture (example: glassy, rough, porous)


By their composition


By the amount of silica


By their color

Answers

Answer:

By the amount of silica

cause igneous rock is classified by their color, texture and chemical composition

__________ commonly cause increased energy and alertness, increased heart rate and respiration, and loss of appetite.

Answers

Answer:

Stimulants commonly cause increased energy and alertness, increased heart rate and respiration, and loss of appetite.

Stimulates commonly cause increased energy

Which process is the one that starts all things off by generating glucose from sunlight? photosynthesis cellular respiration aerobic respiration​

Answers

Answer:

Photosynthesis is the process by which plants, some bacteria, and some protistans use the energy from sunlight to produce sugar, which cellular respiration converts into ATP, the "fuel" used by all living things.

True or False- The thermosphere contains no water vapor.

Answers

Answer:

True

Explanation:

The temperature can rise as high as 1500 C, the gas molecules are very far apart. This layer is completely cloudless and free of water vapour

What do all organisms need? Select three options.

Answers

Answer:

what are the options?

Explanation:

Answer:

food water a place to live

Explanation:

food, water, and protection. A plant is left in a protected greenhouse that pumps in fresh carbon dioxide. The plant also has access to sunlight and can make its own sugar. However, the plant is beginning to die.

Hemoglobin is the oxygen carrying compound found in human blood. It is found to contain 0.3335% iron by mass. It is already known that one molecule of hemoglobin contains four atoms of iron. What is the molecular mass of hemoglobin in g/mol

Answers

Answer:

66986.51 g/mol

Explanation:

According to this question, Hemoglobin- an oxygen carrying compound in the blood, is found to contain 0.3335% iron (Fe) by mass.

* One molecule of hemoglobin contains four atoms of iron

If 1 atom of Fe = 55.85g/mol

Then 4 atoms = 4 × 55.85 = 223.4g/mol

So there are 223.4g/mol of Fe in one molecule of hemoglobin

If hemoglobin contains 0.3335% iron by mass, this mathematically means that:

223.4g/mol of Fe ÷ molar mass of hemoglobin = 0.3335%

That is;

223.4/M.M = 0.3335/100

Cross multiply

0.3335 M.M = 22340

M.M = 22340 ÷ 0.3335

M.M = 66986.51

Hence, the molar mass of hemoglobin is 66986.51g/mol.

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