In order to better understand the dose response relationship of a trispecific T cell engager in multiple myeloma, quantitative systems pharmacology modeling was used. It's true.
Once patients move beyond the accepted standard of care for relapsed and refractory multiple myeloma (RRMM), there are limited therapeutic alternatives available. To encourage T-cell activation and tumor destruction by binding a T-cell receptor and a myeloma target, a number of bispecific T-cell engagers (TCE) are in the clinical development stage for multiple myeloma (MM). The trispecific binds CD28, which acts as co-stimulation for T-cell activation as well as an extra tumor target, in addition to CD3 on T-cells and CD38 on tumor cells.
In order to understand the complex dose response of this medicine, we developed a reliable rule-based quantitative systems pharmacology (QSP) model that was trained against data on T-cell activation, cytotoxicity, and cytokines. According to our predictions, CD3-CD28-CD38 killing capacity will rise quickly at low dosages but will plateau at larger doses instead of following the bell-shaped curve that bispecific TCEs are known for. We also hypothesize that tumor cells' capacity to create synapses with activated T-cells is what drives dose-response curves.
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Correct Question:
Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma. State true or false.
Helpppp me please this question is about the book Born a Crime
Better choices lead to better results (and fewer repercussions). Better decisions could provide you more flexibility and possibilities.
What make a solid decision-making process effective?A intelligent decision-maker picks the best option for themselves and others. They approach making decisions with an open mind and don't let personal preconceptions get in the way. They come to logical conclusions after carefully weighing all of their options and the consequences.
A good decision is one that is careful, intelligent, takes into account and takes into account all relevant considerations, is in line with the person's philosophy and values, and can be communicated to important others.
A person with strong character is one who is aware of and loyal to their own values. They possess a strong moral sense and will stand up for what they believe in, even if it is controversial.
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Whitman kept me from the swamps of a worse uncertainty
The author uses a metaphor in this sentence to -
A describe how lonely she was after the death of her uncle
B. emphasize how directionless she felt during high school
C. illustrate how her parents punished her when she skipped school
D. show how reading poetry taught her a more descriptive vocabulary
Whitman kept me from the swamps of a worse uncertainty The author uses a metaphor in this sentence to - B. emphasize how directionless she felt during high school
What is a Metaphor?This refers to the term that is used in order to show the direct comparison between two or more distinct elements and is the opposite of simile.
Hence, it can be seen that the given metaphor is used so that the author is able to show that the narrator felt directionless in school, but Walt Whitman helped her to have a direction
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An intransitive verb is:
A. an object that receives the action of the verb.
OB. a verb that acts on a direct object and sometimes also takes an
indirect object and an object complement.
C. a verb that takes no objects or complements (e.g., The cat jumps).
D. None of the above are correct.
C. a verb that takes no objects or complements (e.g., The cat jumps).
What is an intransitive verb ?Depending on whether or not an object is necessary for the verb to express a complete notion, a verb is either transitive or intransitive. Only when a verb acts on an object does it make sense as a transitive verb. Without one, an intransitive verb will make sense. Some verbs have dual meanings.
People frequently associate the word transitive with movement, leading them to believe that transitive and intransitive are just more formal expressions for action and inaction, respectively. But whether a verb is active or not has nothing to do with these concepts. Transfer is a more appropriate synonym for transitive. A transitive verb must assign its action to something or someone—an object—in order to be transitive. Essentially, transitive
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which of the following is not an acceptable method of protecting personally identifiable information
Best Practices for PII Security to safeguard personally identifiable information When not in use, keep sensitive PII in a closed desk drawer, filing cabinet, or another secure container.
PII security procedures: When not in use, keep sensitive PII in a closed desk drawer, filing cabinet, or another secure container. If you use sensitive PII, maintain it in a secure location that is only accessible to those who have a need to know the general public.
Best Practices for PII Security Additionally, firms that implement access control policies can aid in preventing accidental PII leak. Using robust encryption, strong passwords, two-factor (2FA), and multi-factor authentication are other best practises (MFA).
What should be done to secure personal information first?
The first step in protecting personal data is centralised administration. Data sharing with unauthorised parties is prevented via centralised control, which guarantees that only authorised individuals may access the information. Additionally, it makes it easier for you to monitor who has access to your data and where it is kept.
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What is an anticlimax?
a) a warning to the reader
b) a reversal of the plot order
c) a statement by another author criticizing the novel
d) shift from something important to something trivial
Anticlimax is an - shift from something important to something trivial.
Examples of anticlimax are provided.When something disappoints you because it follows an extremely because it is not as exciting as you anticipated, it can be described as an anticlimax.
Anticlimax is a figure of speech that refers to the abrupt change from a major to a ridiculous or inconsequential concept in a discourse. Here you are, noble Anna, whom three kingdoms obey, Dost sometimes advice take, and sometimes tea.
an encounter or event that disappoints because it is less interesting or than anticipated or because it occurs right after something considerably more engaging or exciting: When something you've been looking forward to comes to pass, it's frequently a letdown.
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1. They were
in their praise of the new movie.
2.
got tired of his
complaining.
3. It's a
thing, so I didn't bother with it.
4.
let the car
as waited outside his building.
Generally, a precise or unambiguous statement of something in voice In conclusion, In a bid to state in different terms.
What are statements?
The complete statement will be;
They were effusive in their praise of the new movie.I got tired of his perpetual complaining.It's a trifling thing, so I didn't bother with it.I let the car idle as I waited outside his building."Effusive" refers to something that is extremely demonstrative, or that makes a big display of emotion. "Perpetual" is something that is eternal or never-ending." "Trifling" refers to something that is insignificant, or that has no importance. Finally, "idle," when applied to something like a machine or a car, means that the machine is not working, or that it is not active. In other words, it is doing nothing.Ensure simplicity. Long or excessively complicated sentences don't always indicate excellent language construction.Use language that is specific. Utilize parallelism.Watch your grammar. Use appropriate punctuation. Learn to write. A sentence should have the following characteristics in order to be effective: accuracy, unity, clarity, coherence, and emphasis.,that is accuracy. In that situation, individuals might refrain from writing and committing such grammatical mistakes as unfinished sentences. use the phrase "my brother" or the subject.To learn more about Statement refer to:
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The rate that borrowers are willing to pay and lenders are wiling to accept for a particular bond at its risk level is called the bond ___ rate
The rate that borrowers are willing to pay and lenders are willing to accept for a particular bond at its risk level is called the bond market rate
The bond price is the discounted present value of the future cash flow that a bond will produce. It is the total of the present values of all anticipated coupon payments plus the par value at maturity.
A bond's market price is calculated by comparing the current interest rate to the interest rate printed on the bond. There are two components to the bond's market price. The face value of the bond's initial component is its present value. The bond's interest payments' present value makes up the second component.
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Answer: Market
Explanation: just did it
(LC)Which industry did not exist in the United States until the Second Industrial Revolution?
O steel
O railroad
O shipping
O mining
Answer:
Steel
Explanation:
The second industrial revolution expanded the production/usage of electricity Steel and petroleum.
The first industrial revolution had much more to do with transportation, and mining coal.
Pls help it’s due tonight 100 points and brainliest
Answer:
Explanation:
if im supposed to circle one and write 5 sentences on how I feel then this is what I would choose:
circle leafs*
Sing to me, Autumn, with the rustle of your leaves. Breathe on me your spicy scents that flow within your breeze. Dance with me, Autumn, your waltz that bends the boughs of trees. Oh how your beautiful leaves and the colorful viens. Sing to ME, autumn.
Based on your own experiences, do people in the real world feel pressured to be just like everyone
else? Have you ever pretended to be a certain way in order to fit in? If so, how did you pretend?
People in this modern and real world will definitely feel pressured to be just like everyone else. This is because they actually want to wear their shoes which are completely different from their perspectives.
Why people in this world are highly pretend?People pretend to get something they want. Perhaps someone sees something about you that could be of benefit to them, and they feel they should capitalize on that opportunity by putting on an act and making you feel some type of way about them.
People of young age generally pretend to look nice and awesome as compared to others in all perspectives. This psychology always takes up their peace of mind and creates a sense of distraction.
So, it is advised not be pretend to someone and live your own life according to yourself. Please remember to make a version of yourself rather than copying others.
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Infants learn to control their heads before they learn to control their arms, illustrating the ______ rule.
The statement that infants learn to control their heads before they learn to control their arms is best illustrated by cephalocaudal rule. Growth in the cephalocaudal region begins at the top and goes down. The baby grows, the bigger head first, then the rest of the body catches up.
What is Cephalocaudal rule ?
The cephalocaudal rule basically asserts that a child develops from top to bottom, or as they grow, children gain control over their heads first and their feet last.
How does Cephalocaudal rule work ?
It is usually noted that when a newborn baby is held up, the baby's head must be held as well because it cannot do so on its own, but after a month, the baby gains control over his head but yet not on other body parts. After two months, the baby has control over his arms, and after six to seven months, the baby is able to manage itself completely.
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Debbie and Carl don't feel much affection for each other, but neither do they have much to argue about. Which term characterizes their marriage?
a. steady
b. amorphous
c. bland
d. cool
The term that characterizes their marriage is bland.
The term bland is often used to describe relationships or situations that are uninteresting or lacking in excitement or intensity. In the context of a marriage, a bland relationship might be characterized by a lack of strong feelings of affection, intimacy, or connection between the partners. Generally, if a marriage is consistently characterized by a lack of affection and connection, it may be a sign of deeper issues or challenges.
In the given case, Debbie and Carl feel that their marriage is lacking in affection and connection. It is clear that they aren't even communicating much as there is not even an argument about anything between them. This signifies that they are both probably in their own lives and the relationship between them is dull or bland.
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22. What is meant by technical elements of theater?
any play or performance whose themes revolve around technology or advancements
the actors and character motivations and how they are performed on stage
any technology used in the production of a play
the behind the scenes elements that make the story come to life on stage
Answer:
the behind the scenes elements that make the story come to life on stage
Explanation:
The technical elements of theater refer to the behind-the-scenes elements that make the story come to life on stage. This can include lighting, set design, sound effects, and other technical aspects of the production. These elements are essential for creating the desired atmosphere and bringing the story to life for the audience.
Answer:
D. The behind the scenes elements that make the story come to life on stage
Explanation:
What is the function of the gizzard in an earthworm and is there any other animal that has one?
An earthworm's gizzard breaks down nutrients that are challenging to digest. It is present in several kinds of fish and reptiles, as well as in birds and earthworms.
Birds, earthworms, some fish, and reptile species all have muscular stomachs called gizzards, also known as the ventriculus gastric mill. The gizzard is unique in that it breaks down things that are challenging to digest, making it especially helpful to animals without teeth.
The throat, esophagus, crop, and gizzard are all components of an earthworm's digestive system. Earthworms typically consume dirt, which is rich in calcium. Excess calcium must be filtered out by the esophagus. Food moves into the crop after passing through the esophagus. Before entering the gizzard, food is first stored in the crop.
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74) One of the best methods for ensuring that a negotiation proceeds along substantive lines is to frame the discussion around:
Answer is objective criteria ,The greatest way to ensure that a negotiation moves forward along substantive lines is to center the conversation around objective criteria.
Putting Together a Project Team Choose Your Team. Make sure to pick the appropriate folks. Establish the ground rules and the tone. Do this on the first meeting of your team. Having Specific Goals. You need to make specific, attainable goals. They had unclear goals, which meant that their project team was doomed to failure. A project manager engages in arbitration when he renders a decision to disputing parties. A team substantive member who champions a project makes sure that everyone is on board and moving in the right direction to finish it successfully and on schedule. Project champions frequently help project managers mobilize the team.
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Help !!
Some say that when celebrities fall from grace that it provides us with much needed lessons in morality. That it reminds us that they are mere mortals like us and that if you cheat, you lose out and don't deserve the success. What do you think?
Answer:
Ethics and morality are concerned with helping people evaluate how the world ought to be and what courses of action people should take
Explanation:
What is an adjective that describes both the images and the grandeur of god that they represent
Answer: A lamb and a Alter
Explanation:
the command to prevent the termination of a background sort process (which might take a long time to complete) after the user is logged off is:
The command to prevent the termination of a background sort process after the user is logging off is HUP (hang up).
When we want a process to continue running even after you log off a Linux system, we have a couple options. One of the process is to use the disown command. Disown command tells our shell to refrain from sending a HUP (hang-up) signal to the process when you log off. So, the process continues running even after termination of a background sort process.
Another command used to pkill, pkill is one of the commands that can directly used to kill a background process, using the process name.
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In terms of what we assume is an impending diagnosis, which chapter, would you argue, is the most revealing or crucial in understanding what Holden is dealing with, and what he ultimately needs.
Phoebe gradually begins to listen once Holden returns to her room. He tells her everything he detests about school and tries to justify why he consistently fails his classes.
What happens in chapter 22 of Catcher in the Rye?Phoebe gradually begins to listen once Holden returns to her room. He tells her everything he detests about school and tries to justify why he consistently fails his classes. She replies by saying that he despises everything. She dares him to list one thing he enjoys after he attempts to dispute her assertion.He considers his gloves, which were taken at Pencey, as he travels. Though he envisions a complex altercation with the unidentified thief, he admits that at his core, he is a coward who fears conflict and violence. He rides the elevator to his room at the Edmont after arriving.He truly wants to be "the catcher in the rye," though. In Chapter 16, Holden misinterprets the boy's rendition of a Robert Burns song line. If a body is caught coming through the rye, according to Holden, is the line. Phoebe reprimands him.To learn more about The catcher in the rye refer,
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What does freedom means to you in 100 words
Freedom means having the ability to make choices and to live my life in a way that is authentic and true to myself, without being constrained by societal expectations, oppressive systems, or the actions of others. It means having the autonomy to pursue my goals and dreams, to express my thoughts and emotions, and to be able to live my life in a way that brings me joy and fulfillment. Freedom also means having the liberty to be who I am and to be treated with dignity and respect by others. It is a fundamental human right that allows us to live a life that is meaningful and fulfilling :)
For me freedom means many things like:
-Being able to speak my mind
-Having the choice to do something on my own terms
-Being able to choose who I marry/date
-Standing up for myself even if it involves violence
-Having equal rights/pay/respect
-Being able to choose my future/path
I hope this is a 100 words
Where did the fly go? Put in these prepositions appropriately.
around, into, on, out of, through, under, up
1: The flew …… the chair
2: It crawled …….the chair leg.
1.
2.
It crawled .................... the chair leg.
on
It stopped
63
... the desk for a moment.
The prepositions has been put in their appropriate places in the sentence below:
1: The housefly flew over the chair
2: It crawled under the chair leg.
What is a Preposition?This refers to the term that is a part of speech that shows a class of words used to express spatial or temporal relations
Hence, it can be seen that the given sentences have blank spaces that needs to be filled with the appropriate prepositions and they have been given above.
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Communication can be successful when both parties can pay attention, speak, and listen. Also are not distracted by other things that could absorb their interest.
A way communication can be a problem is if the other party isn't listening because of something else being on his mind.
Save your talk for when it's wanted and it's a good time, keep calm, and try to help others more.
Giving, receiving, and exchanging information constitutes the act of communication.
Which 4 forms of communication are there?
There are four basic methods of communication: forceful, aggressive, passive-aggressive, and passive. It is essential to comprehend each communication method and the reasons for its selection.What makes communication crucial?
Your self-concept is shaped by your ability to communicate, which also aids in professional development, understanding of oneself and others, problem-solving, and learning new things.What is the best definition of communication?
The primary objective of communication is to transfer information from one party to another. The act of sharing, expressing, or disseminating information and ideas by writing, speaking, and gesturing is known as communication, according to the Merriam-Webster Dictionary.To know more about communication, checkout this link:
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Proofread the following text and correct the 3 subject-verb disagreements
The revised sentence from the given paragraphs are
(a) From the first paragraph, the word particularly goes with the condition.
(b) From the second paragraph the word, everybody goes with is.
(c) From the third paragraph the word, forecasts are used with enable.
What is the subject-verb agreement?According to the rule of the subject-verb agreement if the subject of any sentence is written in the singular form then the verb is also written in a similar format.
Similarly, if the subject in any sentence is written in the plural format then the verb used also follows a similar structure.
In the given paragraphs, there are errors due to not using the correct rule in sentence formation which is revised.
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The complete question is probably
Proofread the following text and correct the 3 subject-verb disagreements.
Astronomers are telling people to be especially watchful this evening, as a rare event could be making a very special appearance. The release of energised particles from the sun , coupled with particularly helpful overnight conditions , are predicted to make the "Northern Lights" visible much further south than normal.
Interviewed earlier today, Derwent University's Professor Andrew Higgins said, 'Everybody are talking about it. It's a once-in-a-decade opportunity that people really shouldn't miss.'
He added: 'The forecasts given out by the weather office enables us to know when the skies will be clear. Either 11pm or 3am will be best, and I'll be over the moon if we get some good photos.'
What is common writing problem typically address
Answer:
it will be;
Explanation:
poor vocabulary.
1 awkward phrasing and unconventional grammar.
2 inappropriate use of colloquial language.
3 difficulty with sentence structure and word order.
4 trouble reading back what is written.
5 difficulty with word sounds, spelling, and meanings.
hope it helps please mark me as brainliest
1. How is Jem becoming like Atticus, according to
Scout?
In terms of courage and morality, Jem and his father Atticus are extremely similar. He looks up to Atticus and idolizes his father. According to Scout, Jem views Atticus as his role model for masculinity.
How does Jem's personality change?
Jem develops as the story goes on.
Jem starts to distance himself from Scout and prefers to be alone himself. He grows irritable and thinks Scout has to begin to change her ways, acting less like a tomboy and more like a young woman.
What would Jem and Scout say about Atticus?
Atticus was weak since he was around fifty, lament Jem and Scout. The kids think that Atticus is prevented from being a typical parent because of his "advanced" age. After witnessing their father shoot a vicious dog, their perception of him is altered.
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Part One:
Be sure that you have indeed compared or contrasted your novel choice to another piece of fiction or nonfiction literature from the same time period.
Part Two
Also, be sure that you have integrated information from your sources, including:
a primary source (an original document, interview, photo from the time period)
a secondary source (a critical analysis of your novel or a historical document/essay from the time period)
your novel for this module
second piece of literature (poem, short story, another novel)
Part Three:
Once your essay is complete, be sure to include a Works Cited page with the complete list of the sources you used throughout the essay.
The two texts compared and contrasted here are "Romeo and Juliet" and "Hamlet".
"Romeo and Juliet" is a love story, while "Hamlet" is a tragedy about revenge. Both are popular works by Shakespeare.
What is the explanation of the above?"Romeo and Juliet" is a love story about two young people from opposing families who fall in love and want to be together despite their families' animosity. The most essential element in the play is Romeo and Juliet's love, and they are prepared to go to any length to be together.
"Hamlet" is a play about a prince named Hamlet who is out to revenge the death of his father. The drama is filled with violence and treachery, and it delves into themes of insanity, vengeance, and the consequences of our deeds.
Shakespeare wrote both "Romeo and Juliet" and "Hamlet," yet they are extremely different. "Hamlet" is a tragedy, but "Romeo and Juliet" is a love story. "Romeo and Juliet" explores the power of love, whereas "Hamlet" explores the implications of vengeance. Despite their contrasts, both plays remain famous and are regarded as among Shakespeare's finest works.
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The Yellow Wallpaper Unit
Submit Questions from the Articles and for Socratic Discussion
. Three from The Feminist Perspective: The Congresswoman Who
Authored Title IX and Her Personal Fight Against Sexism
Three from The Psychological Perspective: My adult ADHD drugs felt
like a lifeline. Then came the scary side-effects ...
Three for the Socratic discussion
.
I need 9 questions total they can be very basic. From the Yellow Wallpaper.
My psychiatrist replied on our initial check-in call, "Sounds wonderful. The drawbacks—insomnia and an accelerated heartbeat—were mentioned.
Explain about the ADHD?One of the most prevalent childhood neurodevelopmental diseases is ADHD. It is frequently diagnosed for the first time as a youngster and continues throughout maturity. Children with ADHD may struggle to control impulsive behaviors, pay attention, or regulate their level of activity. They may also behave without considering the consequences.
People with ADHD will experience at least two or three of the following difficulties: trouble focusing, difficulty keeping track of time, difficulty paying attention, daydreaming or tuning out, organizational problems, and difficulty remaining on target. Highly sensitive and empathic people with ADHD are common.
Has a lot of problems focusing on tasks or recreational activities. When addressed directly, frequently appears not to listen.
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Based on the information in "Island of Hope, Island of Tears" which statement is accurate?
The onset of World War I caused Frank Kudrna to journey to America from Sardice, Moravia.
The rise of the silk industry caused the village of Mtein, Lebanon, to flourish in the eighteenth century.
Her father breaking his back caused Mary Ramah to immigrate to the United States in 1907.
The Depression caused one of the Sicurella brothers to open a shoe store called "The Creation Bootery."
Based on the information in "Island of Hope, Island of Tears" the statement is accurate is The rise of the silk industry caused the village of Mtein, Lebanon, to flourish in the eighteenth century. Thus the correct option is B.
What is Inference?Inference in any literature piece refers to achieving the conclusion of any subject with the support of facts and evidence present in the particular piece of literature.
The immigrant stories as they faced uncertainty are told in "Island of Hope, Island of Tears." It represents a variety of immigration journeys and embodies the American dream.
Millions of immigrants from around the world came to Ellis Island looking for a better life for themselves and their families. The reasoning behind this movement is explained in the award-winning short documentary Island of "Hope, Island of Tears".
Therefore, option B is appropriate.
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What do the events in the story reveal about the
priorities of Riv and Satch?
Answer:
joe C criticizes Reggie's speech
Explanation:
The events in the story of Riv and Satch reveal a lot about their priorities. Riv and Satch are two friends who live in the same apartment complex, and they have a lot of things in common.
What do both the people love to do ?They both love to play video games, watch movies, and hang out with each other. However, the events in the story show that they have different priorities.
Riv is more focused on his career, and he is willing to put in the extra effort to get ahead. He is willing to work late nights and weekends to make sure he can get the job done.
He also takes the time to learn new skills and to stay up to date on the latest trends in his field. Riv is willing to put in the extra effort to ensure his success and to make sure he can reach his goals. On the other hand, Satch is more focused on having fun. He loves to spend time playing video games, watching movies, and hanging out with Riv.
He is not as concerned with his career as Riv is and is more focused on enjoying life and having fun. Overall, the events in the story reveal that Riv and Satch have different priorities. Riv is focused on his career and is willing to put in the extra effort to make sure he can reach his goals. Satch, on the other hand, is more focused on having fun and enjoying life.
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Which sentence uses the antonym
of the following word?
intimidation
A. My mother reassured me that cheating is
never the way.
B. My bad attitude revealed something about my
character that I was not ready for.
C. We all deserve a second chance in life.
The sentence using antonym of the word intimidation is '(A) My mother reassured me that cheating is never the way' because the word reassured is an antonym of intimidation.
What are Antonyms?
A word that means the exact opposite of another word is called an antonym. Hot and cold, for instance, are antonyms, as are good and bad. All word types, including verbs, nouns, adjectives, adverbs, and even prepositions, can serve as antonyms.Although you can conceive of antonyms as opposites, the term "antonym" comes from the grammar term "antonymy," which refers to words with opposing meanings.By making your words more powerful, antonyms are crucial in writing. Combining opposites draws attention to their distinctions and strengthens each individual word.Here, reassuring implies at relieving someone of any doubt or fear while intimidation implies at instilling fear or rightening someone.Hence, both reassured and intimidation are complete opposites and hence, are called antonyms.To learn more about Antonyms from the given link
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