Sickle cell anaemia is an inherited autosomal recessive
condition caused by a mutation in the haemoglobin
subunit beta (HBB) gene. A male and female who are
phenotypically normal, discover through genetic testing
that they are both carriers of a HBB mutant allele. What is
the probability that their first child will be biologically
female and phenotypically normal?

Answers

Answer 1

Answer:

1/8 (12.5%)

Explanation:

An autosomal recessive disease is an inherited disease in which an individual need to receive both defective alleles at the same gene locus to be expressed in the phenotype. In this case, both parents are carriers of the recessive mutant allele associated with the sickle cell anaemia trait, thereby both parents are heterozygous, ie., each parent has one copy of the normal allele 'H' and one copy of the defective mutant allele 'h' associated with this condition. In consequence, their first child has a 1/4 (25%) chance of having sickle-cell anaemia. Moreover, the chance of having a girl is 1/2 and the chance of having a boy is 1/2, thereby the final chance of having a girl sickle cell anaemia individual is 1/4 x 1/2 = 1/8 (12.5%).

- Parental cross for sickle cell anaemia trait = Hh x Hh >>

- F1 = 1/4 HH (normal); 1/2 Hh (normal); 1/4 hh (sickle cell anaemia) >>  

- Sex proportion of sickle cell anaemia individuals =  1/8 female sickle cell anaemia individuals + 1/8 male sickle cell anaemia individuals (1/8 + 1/8 = 1/4)


Related Questions

Shondra takes notes in class.
Three entries in Shondra's notes are not in the right
place. What can Shondra do to correct her notes?
1. Energy
A Definition - the energy of moving objects
B. Main categories of energy
1. Kinetic - the ability to do work
2 Potential - the energy stored in objects
3. Chemical -- the energy in chemical bonds
C. Forms of energy
1. Gravitational - the energy of a rock on a hill
2 Elastic - the energy in a spring
3. Nuclear - the energy in the nuclei of atoms
4. Electromagnetic wave - the energy from the Sun
5. Electrical - the energy of flowing electrical charges
O Switch "the energy of moving objects" and "the
ability to do work" and place chemical energy under
"Forms of energy."
O Switch "the energy of flowing electrical charges" and
"the energy in a spring" and place kinetic energy
under "Forms of energy."
O Switch "the energy in the nuclei of atoms" and "the
energy stored in objects" and place nuclear energy
under "Main categories of energy."
O Switch "the energy from the Sun" and "the energy of
a rock on a hill" and place electrical energy under
"Main categories of energy."
Mark this and return
Save and Exit
Next
Submit

Answers

Answer:

I beileve its A because energy is what gives the ability to do work

Explanation:

Answer:

A

Explanation:

please have a great day.

Plyometrics can help a person maintain cardiorespiratory fitness true or false

Answers

False
Explanation: Edge



A forest fire destroys an area. A small population of trees and a large population of birds are both affected. Which type
of limiting factor causes this?
density dependent
density independent
population dependent
population independent

Answers

Answer:

B. DENSITY INDEPENDENT

Explanation:

Density independent is a limiting factor. It affect birth and death rates of organisms through abiotic and environmental factors. A forest fire is one of the environmental factors that affects the density of a species in a given location.

The oxidation of a chemical occurs when

It loses electrons
It gains electrons
It shares electrons
All the above

Answers

Answer:

Oxidation occurs when an atom, molecule, or ion loses one or more electrons in a chemical reaction. When oxidation occurs, the oxidation state of the chemical species increases.

Explanation:

oxidation is loss of electrons

here a trick to remember this

oil rig -> oxidation is loss. reduction is gain

Other Questions
A firm has an equity multiplier of 1.57, an unlevered cost of equity of 14 percent, a levered cost of equity of 15.6 percent, and a tax rate of 21 percent. What is the cost of debt Select the correct answer from each drop-down menu.The pancreas is an accessory organ whose function aids the chemical digestion of food.If the pancreas fails to make, it will inhibit the action of enzymes and affect chemical digestion. Also, might damage the small intestine walls. Census data show that the human population doubled from 2.65 billion in 1953 to 5.3 billion in 1990. If it continues to double at this rate, the human population could reach 10 billion by the year 2020. Which best explains how this rate of human growth can harm the environment on which humans depend? what is entrapersonal environment CAPITAL BUILDING:1. What is the purpose of this branchof government in America?2. Who leads this branch?3. How does it check the power of theother branches? You must give 2checks. WHAT IS THE OVERALL IMPACT OF THE MARBURY VS. MADISON CASE? How does your answer compare to this sample? Which choice best describes how your answer compares to the model? My answer matched the sample closely. I said some of the same things that the sample response did. My answer was very different than the sample response. Do you think that every title should be capitalized? yes or no why? 16) How do books and other manuscripts help us understand the medievalhistory of India? Give two examples to support your answers. plz any one help me i need so help i can't finish it so i want help plz!!!!!!! what does perspectives mean when it comes down to weight gain, faster is betterTrue OR False? Suppose the owners of the bank contribute an additional $175 from their own funds and use it to buy securities in the name of the bank. This would increase the securities account a Mary-Jo owns a theater. She purchased a new computer to run the accounting software and lighting for the theater. The computer cost $2,000 and was purchased on May 4, 2020. It was the only equipment purchased by the theater for 2020. Using the MACRS system, how much is her depreciation deduction for 2020 find the product. write your answer in exponential form 99- write a quadratic function f whose zeros are 2 and -6 What is the Cerebellum responsible for? In the diagram of circle O shown to the right, PA and PB are tangent to circle O at points A and B, respectively. If mACB 266, then mAPB 8.Find the slope of the in line containing the ordered pairs. (7 marks)a. A(2,-5), B(-2,6) The modern era came about, in part, because of which historical event?A. The French RevolutionB. The fall of the Qing DynastyC. The American Civil WarD. The Industrial Revolution