Suppose a researcher introduces a mutation into the glucosidase domain of the mammalian glycogen debranching enzyme. The mutation inhibits the activity of the glucosidase but does not affect the other functions of the enzyme. The researcher then introduces the mutated enzyme into mammalian cells that do not express wild type glycogen debranching enzyme. Predict the effect of the mutation on glycogen metabolism.

Answers

Answer 1

Answer:

cells will have glycogen molecules with branches of a single glucose residue

Explanation:

Glycogen debranching enzymes are proteins that catalyze the removal of branching from glycogen, which is a multibranched polysaccharide composed of glucose units and serves as a form of energy storage. These enzymes have two catalytic activities on a single polypeptide chain: glucosyltransferase and glucosidase activities, which are both required for glycogen breakdown. Glycogen degradation requires both glycogen phosphorylase and glycogen debranching enzymes. First, a glycogen phosphorylase acts to digest a glycogen branch down to four glucose residues. Subsequently, the debranching enzyme through its glucosyltransferase activity acts to transfer three glucose residues to a nearby branch of the glycogen chain. Finally, through its glucosidase activity, the debranching enzyme cleaves the remaining α-1,6 linkage in order to release free glucose.


Related Questions

Why can't we meet all of our protein needs in one meal?

Answers

Because most people go for what tastes good rather than what is protein rich, and what tastes good is usually high in fat and carbohydrates, as opposed to proteins.

During transcription, RNA polymerase synthesizes RNA from a DNA template with the help of accessory proteins.

a. True
b. False

Answers

Answer:

The correct answer is a. True

Explanation:

The information to produce a protein is coded in the cells in deoxyribonucleic acid (DNA). Transcription is the process in which a DNA sequence is copied into a ribonucleic acid (RNA) sequence. This RNA sequence is a messenger RNA (mRNA) because it will be then translated into a functional protein. For this, the DNA sequence is read and an RNA strand is synthesized by an RNA polymerase (an enzyme that synthesizes RNA molecules from a DNA template). During the process participate other proteins, such as DNA binding proteins, activators, coactivators, etc. (accessory proteins).

which primitive organic molecule was essential to form lipid bilayer?​

Answers

Answer:

autocatalytic RNA is the primitive organic molecules was essential form liquid bilayer .

The neurons that carry from the brain to the muscle are called ?

Answers

Answer:

Motor Neurons

Answer:

The neurons that carry messages to the muscles are called motor neurons.

This is the last

What are the vestigal organs present in human body??​

Answers

Answer:

Charles Darwin listed a number of putative human vestigial features, which he termed rudimentary, in The Descent of Man (1871). These included the muscles of the ear; wisdom teeth; the appendix; the tail bone; body hair; and the semilunar fold in the corner of the eye.

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Biomagnification results in higher amounts of toxic substances for organisms on the food chain
True
False

Answers

Answer:

Biomagnification results is higher in amount of toxin substances so the answer is true

Explanation:

• Describe genetic______ and gene_________ as mechanisms of evolution.

Answers

Answer:

genetic is branch of science deal with study of heredity and genes

genes is segment of DNA which transfer parental character from one generation to another

if you look away from this sentence and focus your eyes on a distant object, the eye muscles _______ to focus images on the retinas

Answers

If you look away from this sentence and focus your eyes on a distant object, the eye muscles relax to focus images on the retinas.

Bert has blonde hair (b). Molly has brown hair (B), but her genotype is Bb, meaning she carries a recessive blonde allele. What is the likelihood of Bert and Molly's second child having brown hair?

Answers

Answer:

50%

Explanation:

Iif you do a punnet square you get Bb, Bb, bb, and bb

since blond is represneted by the recessive bb it's a 50% the child will have blond hair

What is Alzheimer's disease??​

Answers

Answer:

Alzheimer's disease is a progressive neurologic disorder that causes the brain to shrink (atrophy) and brain cells to die.

Explanation:

Hope it is helpful.

Thankyou

Answer:

Alzhimers disease is a progressive neurologic disorder that causes the brain to shrink and brain cells to die . Alzhimers disease is the most common causes of dementia - a continious decline in thinking behavorial and social skills that affects persons ability to function indepedently .

Los microondas tienen una frecuencia mayor a las ondas de radio. verdadero o falso,justifique

Answers

Los microondas tienen una frecuencia mayor a las ondas de radio.Verdadero o Falso.

Verdadero.

→ Porque, los microondas con/y las radiofrecuencias son radiaciones electromagnéticas de mayor frecuencia.

SALUDOS!

MiraculousAlejandra

What is the answer with explaining

Answers

Answer:

EeWw

Explanation:

This question involves two genes; one coding for earlobes and the other for hairline. According to the question, one parent is homzygous recessive for earlobe but homzygous dominant for hairline i.e. (eeWW) while the other parent is homzygous dominant for unattached earlobes but homzygous recessive for hairline i.e. (EEww).

The cross between the two parents is as follows: eeWW × EEww. The following gamete combination will be produced by each parent:

eeWW - eW, eW, eW, eW

EEww - Ew, Ew, Ew, Ew

Using these gametes in a punnet square, the following proportions of offsprings will likely be produced:

All EeWw offsprings

Which is the main light-absorbing pigment for photosynthesis?
O carotene
O chlorophyll
O hemoglobin
O anthocyanin

Answers

Answer:

Chlorophyll

Explanation:

Chlorophyll, the primary pigment used in photosynthesis, reflects green light and absorbs red and blue light most strongly.

In plants, photosynthesis takes place in chloroplasts, which contain the chlorophyll.

Answer:

B) Chlorophyll

Explanation:

The chloroplasts, which contain the green pigment chlorophyll, are where photosynthesis takes place. Chlorophyll is the pigment that gives plants their distinctive color. It works by collecting the energy in the sunlight that strikes the plant. Because grass requires photosnthesis to create glucose, which is required for growth inside the grass, photosynthesis is critical to life on Earth. As a result, creatures that eat the grass get energy, and so on. As a result, photosynthesis is the mechanism through which energy is introduced into an environment.

OAmalOHopeO

All human impacts on the environment, such as the depletion of natural resources, are significantly worsened by __________. air and water pollution climate change human population growth agricultural practices

Answers

Answer:

overpopulation

Explanation:

this along with the others listed have triggered climate change and soil erosion

Please help;
Given the range of current speeds shown on the graph above, would deposition ever be possible for clay (0.001 mm) or silt (0.01mm) particles?
Answer yes or no and explain your answer.

Answers

Answer:

Yes.

Explanation:

Yes, deposition can be possible for clay (0.001 mm) and silt (0.01mm) particles when the agent that carry its load is absent in that region such as wind. Wind is the agent that moves clay and silt particles with it so if there is high wind in a specific region, no deposition will occur while on the other hand, those areas where wind is not present, deposition will definitely occurs so we can say that deposition depends on the presence and absence of wind.


The layer of soil that contains the most organic material is called the
a. A
C C
b. B
d D

Answers

Answer:

That layer is called the a horizon, so the answer is A.

Explanation:


What happens when the density of a medium increases?

Answers

A substance that is more dense per volume has more mass per volume. Usually, larger molecules have more mass. If a material is more dense because its molecules are larger, it will transmit sound slower.

A student wants to determine how his classmates feel about school. He does a survey away from school so all participants will be willing to answer freely. In several cases, younger siblings of his classmates are present, so he lets them take the survey too. He surveys a total of 50 students. Has he done a well-designed, controlled experiment

Answers

Answer:

ojjjososkjsjeiemejekliijahaupamahdh

What kind of claim type does this statement make? Abbey Road is a much better album than Let It Bleed.

Select one:
a.
value
b.
policy
c.
fact

Answers

A . Value because that’s your valued opinion

The kind of claim type does this statement is the value claim.

A claim of value refered to something as either good or bad, or that one thing is better than another thing.

Example of value: Abbey road album is better than let it bleed.

Conclusively we can therefore say that option A is the answer that best fit the statement above.

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what is the waterfalls ​

Answers

Answer:

waterfall is a falling of a river or other body of water over a steep Rocky ledge. Shows interruption in water flow

Which answer option below describes the best way to increase the accuracy of a
confidence interval calculation?

Answers

The answer is c but this has to be twenty characters long

The accuracy of a confidence interval calculation can be increased from  95% to 99%.

Thus, option C is correct.

What is confidence interval?

A confidence interval contain a population parameter in a specified proportion of the time, which can be computed using the given confidence level from a limitless level of individual sample.

The proportion of the range consists of the true value of the factor that will be identical to the confidence level.

In most of the confidence interval examples, the confidence level chosen is 95%. and it can be raise up to 99%.

It cannot estimate the plausible values of the unknown parameter of the population.

Two types of confidence interval observed such as accuracy which is defined based on whether the confidence interval contains the true population parameter or not.

Secondly, the precision defined in terms of the width of a confidence interval.

Hence, option C is correct.

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what is the source of food for germinating seed ?​

Answers

Endosperm is the reservoir of nutrients in the developing embryo or germinating seed.

Regards
BLACKSHARK

Macronutrients is the most readily available for energy production

Answers

Answer:

The correct answer is - true.

Explanation:

All the macronutrients carbohydrates, fats, and protein all three produce energy. Carbohydrates are the most preferred source of energy for the human body as it is the macronutrient that your system most requires.

The human body easily breaks down most carbohydrates and provides a significant amount of energy. The energy-providing process is called cellular respiration starts with glucose as a substrate. Glucose is the simplest carbohydrate.

explain how the mammalian skin perform it's role as a thermoregulatory



Answers

Answer:

The skin contains many blood capillaries and sweat glands ,the sweat glands secrete sweat when it is hot.when the sweat evaporates from the skin it cools the body.thermoregulation by the skin occurs through dilation and constriction of the blood vessels.when the bodies temperature raises,the blood vessels carry heat in the blood to the skin.the blood capillaries dilate become wider so that more heat can be lost to the environment.this is called vasodilation.when the outside temperature is low,the blood capillaries constrict become narrower so that less blood flows to the surface of the skin.therefore less heat is lost to the environment this is called vasoconstriction.

I hope this helps

8.Explain how is small intestine designed to absorb digested food.
9. Write two differences between the nutrition in amoeba and human beings.
10. Fungus can be harmful and useful. Give an example showing both of these traits of fungus.

Answers

Answer:

10. Fungus are useful as they act as decomposers and decompose the dead things. Fungus are harmful as they can decompose fruits, grains and plants etc.

The immunoglobulin light chain does not have a D segment. In humans, there are two different possible light chain proteins, termed kappa and lambda. Assume that there are 35 V segments and 5 J segments in the human kappa light chain region, and there are 30 V segments and 4 J segments in the human lambda light chain region. How many possible light chain genes can be created from these different segments, simply due to combinatorial diversity

Answers

Answer:

295  

Explanation:

Antibodies (also known as immunoglobulins) are immune system-related proteins that circulate in the bloodstream in order to recognize pathogenic harmful substances (antigens) and neutralize them. An antibody consists of two immunoglobulin heavy chains and two immunoglobulin light chains. There are two types of immunoglobulin light chains: 1-the kappa (κ) light chain, which is encoded by the immunoglobulin κ locus; and 2-the lambda (λ) light chain, which is encoded by the immunoglobulin λ locus. The immunoglobulin light chain is a multidomain protein composed of two domains: 1- the N-terminal variable (V) domain and 2-the C-terminal constant (C) domain. V(D)J recombination is a type of somatic rearrangement process by which T and B cells can assemble different gene segments, which are referred to as variable (V), diversity (D) and joining (J) gene segments. In the question above the number of possible genomic recombination events between immunoglobulin gene segments can be calculated as >> (5 x 35) + (4 x 30) = 295.

Below is an image of a nucleus before it divides via meiosis. The chromosomes shown in red are from the female parent, and the chromosomes
in blue are from the male parent. Predict the gametes that can be created from this organism and explain the reason these different gametes are
possible.

Answers

Answer:

I predict that the gametes will be unique from their parents.

Explanation:

I predict that the chromosomes will pair up, with each pair having a red chromosome and a blue chromosome, then they'll cross over and exchange similar genetic information with each other. I think this because variety is important for any species for survival.

What is the correct order of the levels of organization in animals from smallest to largest?​

Answers

Answer:

Molecules, cells, tissue, organ, organ system, organism, population, community, ecosystem, and biosphere are in the correct order of the organization's levels.

Explanation:

Molecule: Atoms, the smallest unit of chemical elements are built up of molecules. You can find it in any matter, whether it lives or not. The most fundamental structures of biological creatures are molecules. Biochemistry and molecular biology are two biological fields focused on this level.

Cell: A cell is the basic unit of life. Two types of cells exist plant cells with a stiff cell wall consisting of cellulose molecules and animal cells with a flexible cell membrane. Cell biologists examine problems like metabolism and other structure and functional questions within and between cells.

Tissue: Tissue consists of cells working together to accomplish a goal. Some tissues include muscle, connective tissue, and neural tissue. Examples of biologists working at this level are histologists.

Organ: An organ is a tissue system that works at bigger scales together to perform specified work in the body of an animal. Brain, heart, and lungs are examples of organs. Anatomy is an example of a specialty in biology which concerns this level.

Organ system: An organ system is a group of bodies that work together to fulfill certain activities of the body. Air systems are used to inhale oxygen and release carbon dioxide in animals, for example, by the lungs, respiratory tract, and muscles. The function of the corpus when working jointly is studied by physiologists. Although physiologists can work at any level, they commonly address queries about organ systems.

Organism: An organism is an autonomous and recognized person. The organisms might be single-cell or multi-cell organisms consisting of organisms and organ systems, as well as bacteria, amiable, or creatures. An example of a multi-cellular organism is a human being.


Which of the following parts of a prokaryote is the part of the cell membrane that is folded in and thought to be used
for helping DNA replicate?
A. Mesosome
B. Genophore
C. Peptidoglycan
D. Cell wall

Answers

Answer:

a

Explanation:

: an organelle of bacteria that appears as an invagination of the plasma membrane and functions either in DNA replication and cell division or excretion of exoenzymes.

The following part of the cell membrane that is folded in and thought to be used for helping DNA replicate is the mesosome. The correct option is A.

What is mesosome?

Mesosome is a round organelle that is present in prokaryotic organisms like bacteria. These organisms present as introversion in the plasma membrane. This organ helps in many functions of the cell like DNA replication and cell division.

DNA replication is a process of replicating DNA in other cells. It happens in the process of cell division. In bacteria cells, mesosomes help in the distribution of DNA into the daughter cells during the division.

Thus, the correct option is A. Mesosome regarding the organelle present in the bacteria helps in DNA replication.

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Ġ Surface area te volume ratio plays a vital role in À. growth rate of organisms B. exchange of materials between organisms and their environment C. the life-span of organisms D. efficiency of various systems in organisms

Answers

Answer:

Exchange of materials between organisms and their environment

Explanation:

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