Why would mutation of a tyrosine residue to glutamate in the intracellular portion of a growth factor receptor lead to increased tumor formation

Answers

Answer 1

Answer:

this mutation leads to a constitutively active state where the receptor can not be inactivated by dephosphorylation  

Explanation:

Phosphorylation is a posttranslational modification that usually occurs at the side chains of serine, tyrosine and threonine residues, thereby regulating protein function. Phosphomimetic amino acids are substitutions (mutations) able to mimic the phosphorylated form of the protein, resulting in constitutive activation/inactivation of the corresponding protein. In this case, it is expected that the substitution of tyrosine to glutamate gives rise to a constitutively active state of the receptor by replacing tyrosine with a phosphomimetic residue.


Related Questions

What should Brenda do when a patient wants to make payments on an outstanding patient account balance?

Answers

Answer:

Brenda should facilitate the patient's resolve to make the payments by ensuring that an effective schedule is worked out with the patient and that the patient is able to stick to the agreed schedule.

Explanation:

Brenda should always make sure that patients are encouraged to make good on their promises to pay for their medical treatment.  She should be compassionate with the patient by showing understanding and sharing information on payment terms.  She should be very creative in scheduling payments in such a way as to ensure that the patient makes payments as scheduled.  She can even work out some fees for late payments to encourage the patient to stick to the schedule.

how does a beneficial trait increases an organism's survival and potential reproductive success.

Answers

Answer:

This cumbersome trait significantly decreases the male's chances of survival. ... natural selection: that is, that organisms better adapted to their environment would benefit from ... the individual's reproductive success, even at the expense of their survival (Darwin 1871). ... A successful male can potentially sire many offspring.

Explanation:

The beneficial trait increase the survival and potential reproductive success of the organism as they help organism to thrive in their unfavorable changing environment.

Natural selectionThe natural selection can be defined as the differential survival and reproduction of those organisms which have beneficial traits over others.For example, the color change in chameleon helps them to remain undetected from predator population as well as from prey so it helps in increase in rate of survival of chameleon also helps them to reproduce and increase in number.

Hence, beneficial traits increase the rate of survival and reproduction of organisms.

Learn more about natural selection:

https://brainly.com/question/9830102

1. What is an operon?

a. The binding site for a repressor PRO.

b. Any group of genes responsible for the metabolism of lactose in a prokaryotes or eukaryotes.

c. A cluster of genes under the control of a promoter.

d. A regulatory gene.

Answers

Answer:

The answer is D

Explanation:

Answer: c! I think, hope this helped

The mass of a cylinder of beetroot was 2.5 g. If its final
mass was 2.7 g, what was the
increase in mass in per cent?

Answers

Answer: The percent increase in the mass of cylinder of beetroot is 8%.

Explanation:

To calculate the percent increase in the mass of cylinder, we use the equation:

[tex]\%\text{ increase in mass}=\frac{\text{Final mass - Initial mass}}{\text{Initial mass}}\times 100[/tex]

We are given:

Final mass of the cylinder = 2.7 g

Initial mass of the cylinder = 2.5 g

Putting values in above equation, we get:

[tex]\%\text{ increase in mass}=\frac{2.7-2.5}{2.5}\times 100\\\\\%\text{ increase in mass}=8\%[/tex]

Hence, the percent increase in the mass of cylinder of beetroot is 8%.

CAN SOMEONE PLEASE HELP ME WITH THIS SCIENCE QUESTION I WILL MARK YOU BRAINLIEST THANK YOU

Answers

Answer:

The answer is

A. methane

Challenge: Make another comparison.
Earth's outer layer is like

Answers

Earths outter layer is like the glass on a lightbulb because it keeps the inside of the lightbulb straight, and also protects you from getting electrocuted (sry if this is wrong, i tried my best to try to help) :))

giving brainiest
Scientists find fossils of a wide variety of dinosaur species throughout Mesozoic rocks, which date from approximately 250 million to 65 million years ago. Above the Mesozoic rocks lie Cenozoic rocks, which date from approximately 65 million years ago to the present day. No dinosaur fossils exist in the overlying Cenozoic rocks.


What is the most likely explanation for the lack of dinosaur fossils in Cenozoic rocks?

A. The dinosaurs' biological diversity increased in the Cenozoic Era.

B. Dinosaurs adapted in the Cenozoic Era so that their bodies could no longer be preserved as fossils.

C. There was a mass extinction of dinosaur species at the end of the Mesozoic Era.

D. There was a mass extinction of dinosaur species at the end of the Cenozoic Era.

Answers

Answer:

C

there awasw a mass extinction of dinosaur species at the end of the Mesozoic.

Explanation:

C

Have A Great One!

Answer:

it D

Explanation:

Which optical phenomena are formed by water droplets?

Answers

One of the most common and well known atmospheric optics, the rainbow is formed when sunlight is refracted and reflected by water. A collection of droplets in the atmosphere — whether from rain, a waterfall, a sprinkler, etc. — disperses the entire visible light spectrum at an angle, resulting in the circular shape.

if something is burned a reaction has occurred

Answers

Answer:

true

Explanation:

When the reactants are heated, the average kinetic energy of the molecules increases. This means that more molecules are moving faster and hitting each other with more energy.

HOPE IT HELPS

Answer:

Combustion reaction

Science. Help I really need this giving brainliest to the person with the correct answer, please explain your answer...........

Answers

Answer:

A and B

Explanation:

What is the independent variable?
What is the dependent variable?

Answers

I need more context please

plss helppp!!

Which of the following is an example of indirect evidence about Earth's
layers?
A. rock samples obtained by drilling
B. mantle rocks produced by volcanoes
C. changes observed in seismic wave data
D. data gathered from high-pressure lab experiments

Answers

Answer: I believe the answer would be C -- Changes observed in seismic wave data.

Explanation:

Geologists use rock samples as direct evidence about earth's layers, and they  use seismic waves as indirect evidence to study the Earth’s structure.

I hope this helps!

The Earth is ________________of years old

Answers

Answer:

the earth is 4.543 billion years old

Which type of wave forms at the boundary between air and water in the open

ocean?


A. Surface

B. Longitudinal

C. Electromagnetic

D. Transverse

Answers

Answer:surface

Explanation:

Just believe me miss gorl

Answer:

surface waves form at the boundary where air and water meet in open ocean.

Explanation:

Just did the quiz.

What heat transfer method gives plants the energy they need for photosynthesis to take place?
Conduction
Convection
Radiation
Glucose

Answers

Answer: radiation

Explanation:

Answer:

Radiation

Explanation:

plants need radiation to produce sunlight in order for them to carry out photosynthesis

the type needed is photosynthetically active radiation (PAR)

what amendment to the us constitution had the police violated​

Answers

Answer:    Fourth Amendment

Explanation:

Did you mean: what amendment to the us constitution has the police violated​

Fourth Amendment.

Which antibody class was produced first in this sequence of events

Answers

Answer:

IgM

Explanation:

........ ............ .

Pls help :)) worth 10 points (:

Answers

Answer:

A

Explanation:

just go for A

If two hybrid tall pea plants are crossed what is the probability that the offspring will have the tall phenotype?

Answers

Answer:

There is a high probability that the Pea plant will have a High phenotype!

Explanation:

Because both "parent plants" are tall, this will cause the offspring to also be tall, this will be because it in it's genes or in other words DNA too be strong.

4.
What is the importance of biodiversity to humans and to ecosystems?

Answers

Answer:

Ecological life support- biodiversity provides functional ecosystem that supply oxygen, clean air and water, pollination of plants, pets, control, wastewater treatment and many ecosystem services.

Explanation:

looked it up

Why is your body going through physical and chemical changes?

Answers

Answer:

(MY) body is only going through chemical changes because of my digestive juices, my saliva, and brain functions.

Explanation:

{MY} body isn't going through many physical changes other than my body slowly breaking down on a nuclear level every day slowly just like everybody else that's why nobody dies of old age, its just the teardown of their body eventaully giving out

What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain

Answers

Answer:

TNF-alpha is expressed as a homotrimer that exerts its activities through binding to two types of receptors: TNFR1 and TNFR2, which are transmembrane glycoproteins characterized by having an extracellular domain with 4 cysteine-rich domains (CRD 1-4) , each with 3 cysteinecysteine disulfide bonds.

Explanation:

TNF-alpha (Tumor Necrosis Factor), which has the characteristic of being a paracrine signaling ligand, is a pleiotropic cytokine that functions as a mediator of immune regulation, the inflammatory response and apoptosis in some cell types. Receptors in this family are involved, with some exceptions, in juxtacrine signaling; that is, both the ligand and the receptor are membrane proteins with extracellular domains through which signaling is established. The cellular responses promoted by TNF are initiated by its interaction with two different types of cell receptors, the type I receptor (55 kDa) and the type II receptor (75 kDa). Both types of receptors are part of the TNF receptor family, members of which include Fas antigen (apoptosis inducer, also called Apo-1 or CD95), CD27 (T-cell activation antigen), CD30 (lymphoma marker Hodgkin) and CD40 (B-cell antigen), which share the characteristic of cysteine-rich sequences in their extracellular domains. This family of cytokines generate cellular responses that include differentiation, proliferation, activation of NFκB and cell death, promoting the aggregation of receptor monomers, that is, they have a transmembrane domain that participates in the solubilization of the receptor and a domain of intracellular death that is involved in signal transduction. The binding of TNF to TNF-R1 induces a signaling cascade through its intracellular death domain, which subsequently leads to the activation of complex I (or inflammatory) of NFkB and proceeds to the transcription of anti-apoptotic genes, pro- inflammatory diseases and apoptosis complex II (caspases).

plz help me i beg of you!???

Answers

Answer:

Pretty sure it's D, because the birds beak evolves to crush those grains as a result of certain food available in their habitat, although it does not say "diet" as an option so D is your best guess.

Explanation:

How can you recycle your trash?

Answers

Answer:

when people recycle they really just need to pickup after themselves

Answer:

cleaning up after yourself, learning the proper way to decompose of things, throw trash out and recycle plastic by picking it up, clean up cans, and tell others to help out!

Which type of cell are found in the leaves of a tree?
O eukaryotic animal
O chloroplastic
O prokaryotic
O eukaryotic plant

Answers

Answer:

Palisade parenchyma cells

Explanation:

Palisade parenchyma cells are elogated cells located in many leaves just below the epidermal tissue. Spongy mesophyll cells occur below the one or two layers of palisade cells. Ray parenchyma cells occur in wood rays, the structures that transport materials laterally within a woody stem.

Answer:

eukaryotic plant

Explanation:Unit 2 Test: Cells

The time it takes an object to go around another object (one year) is

Answers

Answer:

365 days

Explanation:

Based on the synthesis reaction what would the product of the reaction be? NaPO3+CuO

Answers

the answer is NaCuPO4

Answer: NaCuPO4

Explanation:

What is and example of an molecule
Muscle tissue
Protein
Stomach
Unicellular organism

Answers

An example of an molecule is Protein

Can someone do this. I will give brainlist!!

Answers

Guanine(G) pairs with Cytosine(C) through a triple hydrogen bond

Adenine(A) pairs with Thymine(T) in DNA, but in this case Uracil(U) because we have a RNA strand therefore:

1.Cytosine

2.Uracil

3.Adenine

4.Guanine

Hi there, in this table what exactly are you supposed to complete as I am not completely sure about it so can you please explain it to me?
Thanks

The pigment plants have that they use for photosynthesis is called ————

I don’t want a explanation I just want the answer


Answers

Answer:

chlorophyll is the answer

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